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Using an IL-27 reporter transgenic mouse model, we show in this study that conventional type 1 dendritic cell IL-27 production in the draining lymph node 12 h after s.c. vaccination directly correlates with downstream CD8+ T cell memory and protective immunity against infectious challenge. This correlation is robust, reproducible, predictive, entirely unique to vaccine biology, and is the only innate correlate of CD8+ T cell immune memory yet to be identified. Our results provide new insights into the basic biology of adjuvant-elicited cellular immunity and have clear implications for the screening and evaluation of novel adjuvants.<\/jats:p>","DOI":"10.4049\/jimmunol.1901357","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T23:04:19Z","timestamp":1577142259000},"page":"510-517","source":"Crossref","is-referenced-by-count":20,"title":["cDC1 IL-27p28 Production Predicts Vaccine-Elicited CD8+ T Cell Memory and Protective Immunity"],"prefix":"10.1093","volume":"204","author":[{"given":"Augustus M","family":"Kilgore","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-7843","authenticated-orcid":false,"given":"Nathan D","family":"Pennock","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University , Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-7895","authenticated-orcid":false,"given":"Ross M","family":"Kedl","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"2025030417510483300_r1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/B978-0-12-394590-7.00005-1","article-title":"Probing CD8 T cell responses with Listeria monocytogenes infection","volume":"113","author":"Condotta","year":"2012","journal-title":"Adv. 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