{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:52:27Z","timestamp":1776217947236,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":1701,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DP1-AI131080"],"award-info":[{"award-number":["DP1-AI131080"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty Scholars Program"},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["Investigator in the Pathogenesis of Infectious Disease Award"],"award-info":[{"award-number":["Investigator in the Pathogenesis of Infectious Disease Award"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011636","name":"March of Dimes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vaccines against Zika virus (ZIKV) infection that target CD8+ T cells are of considerable interest because Abs may enhance infection susceptibility. However, whether CD8+ T cells are protective or promote susceptibility to clinical infection symptoms remains uncertain. To more precisely investigate ZIKV-specific CD8+ T cells in isolation, we engineered a Listeria monocytogenes\u2013based vector to express a single MHC class I\u2013restricted immune dominant peptide, E294\u2013302, from ZIKV envelope protein. We show accumulation of activated ZIKV-specific CD8+ T cells primed by recombinant L. monocytogenes is associated with reductions in circulating virus levels after ZIKV challenge in type I IFN receptor\u2013deficient mice and wildtype mice administered neutralizing Abs against type I IFN receptor. Interestingly, susceptibility to ZIKV clinical infection including weight loss and mortality each persists and is neither significantly improved nor worsened compared with isogenic L. monocytogenes\u2013primed control mice. These data demonstrating persistent ZIKV clinical susceptibility despite reduced viral burden in mice with expanded virus-specific CD8+ T cells highlights the need for targeting other adaptive immune components in developing vaccines against ZIKV infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1901412","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T15:46:56Z","timestamp":1591804016000},"page":"447-453","source":"Crossref","is-referenced-by-count":2,"title":["Persistent Zika Virus Clinical Susceptibility despite Reduced Viral Burden in Mice with Expanded Virus-Specific CD8+ T Cells Primed by Recombinant\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7754-8355","authenticated-orcid":false,"given":"Ashley R","family":"Burg","sequence":"first","affiliation":[{"name":"Center for Inflammation and Tolerance, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"},{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-9302","authenticated-orcid":false,"given":"John J","family":"Erickson","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-9745","authenticated-orcid":false,"given":"Lucien H","family":"Turner","sequence":"additional","affiliation":[{"name":"Center for Inflammation and Tolerance, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"},{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-7759","authenticated-orcid":false,"given":"Giang","family":"Pham","sequence":"additional","affiliation":[{"name":"Center for Inflammation and Tolerance, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"},{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-1344","authenticated-orcid":false,"given":"Jeremy M","family":"Kinder","sequence":"additional","affiliation":[{"name":"Center for Inflammation and Tolerance, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"},{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8948-1952","authenticated-orcid":false,"given":"Sing Sing","family":"Way","sequence":"additional","affiliation":[{"name":"Center for Inflammation and Tolerance, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"},{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"2026041420284786400_r1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat. 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