{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:21:48Z","timestamp":1790572908870,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R01 A1041158"],"award-info":[{"award-number":["R01 A1041158"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK087635"],"award-info":[{"award-number":["R01 DK087635"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012781","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Clinical and experimental studies have established that immune cells such as alternatively activated (M2) macrophages and Th17 cells play a role in the progression of chronic kidney disease, but the endogenous pathways that limit these processes are not well understood. The cytokine IL-27 has been shown to limit immune-mediated pathology in other systems by effects on these cell types, but this has not been thoroughly investigated in the kidney. Unilateral ureteral obstruction was performed on wild-type and IL-27R\u03b1\u2212\/\u2212 mice. After 2 wk, kidneys were extracted, and the degree of injury was measured by hydroxyproline assay and quantification of neutrophil gelatinase\u2013associated lipocalin mRNA. Immune cell infiltrate was evaluated by immunohistochemistry and flow cytometry. An anti\u2013IL-17A mAb was subsequently administered to IL-27R\u03b1\u2212\/\u2212 mice every 2 d from day of surgery with evaluation as described after 2 wk. After unilateral ureteral obstruction, IL-27 deficiency resulted in increased tissue injury and collagen deposition associated with higher levels of chemokine mRNA and increased numbers of M2 macrophages. Loss of the IL-27R\u03b1 led to increased infiltration of activated CD4+ T cells that coproduced IL-17A and TNF-\u03b1, and blockade of IL-17A partially ameliorated kidney injury. Patients with chronic kidney disease had elevated serum levels of IL-27 and IL-17A, whereas expression of transcripts for the IL-27RA and the IL-17RA in the tubular epithelial cells of patients with renal fibrosis correlated with disease severity. These data suggest that endogenous IL-27 acts at several points in the inflammatory cascade to limit the magnitude of immune-mediated damage to the kidney.<\/jats:p>","DOI":"10.4049\/jimmunol.1901463","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T19:45:21Z","timestamp":1591818321000},"page":"377-386","source":"Crossref","is-referenced-by-count":18,"title":["Loss of IL-27R\u03b1 Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses"],"prefix":"10.1093","volume":"205","author":[{"given":"Gaia M","family":"Coppock","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Renal, Electrolyte, and Hypertension Division, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian R","family":"Aronson","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Section of Surgery, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"Park","sequence":"additional","affiliation":[{"name":"Renal, Electrolyte, and Hypertension Division, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Renal, Electrolyte, and Hypertension Division, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-9181","authenticated-orcid":false,"given":"Jeongho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-8228","authenticated-orcid":false,"given":"Jonathan H","family":"DeLong","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Radaelli","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-3726","authenticated-orcid":false,"given":"Katalin","family":"Suszt\u00e1k","sequence":"additional","affiliation":[{"name":"Renal, Electrolyte, and Hypertension Division, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"2025030417504297300_r1"},{"key":"2025030417504297300_r2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-immunol-032712-095937","article-title":"The immunology of fibrosis","volume":"31","author":"Wick","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417504297300_r3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3523","article-title":"The immune system and kidney disease: basic concepts and clinical implications","volume":"13","author":"Kurts","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417504297300_r4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1681\/ASN.2014040320","article-title":"Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury","volume":"26","author":"Belliere","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025030417504297300_r5","doi-asserted-by":"crossref","first-page":"F1043","DOI":"10.1152\/ajprenal.00389.2012","article-title":"Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis","volume":"304","author":"Han","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2025030417504297300_r6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143961","article-title":"The role of M2 macrophages in the progression of chronic kidney disease following acute kidney injury","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"2025030417504297300_r7","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2119\/molmed.2012.00131","article-title":"MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages","volume":"18","author":"Braga","year":"2012","journal-title":"Mol. Med."},{"key":"2025030417504297300_r8","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/ajt.12803","article-title":"The role of macrophages in the development of human renal allograft fibrosis in the first year after transplantation","volume":"14","author":"Toki","year":"2014","journal-title":"Am. J. Transplant."},{"key":"2025030417504297300_r9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ki.2008.602","article-title":"Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes","volume":"75","author":"Ascon","year":"2009","journal-title":"Kidney Int."},{"key":"2025030417504297300_r10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000343283","article-title":"CD4+ T Lymphocytes, especially Th2 cells, contribute to the progress of renal fibrosis","volume":"36","author":"Liu","year":"2012","journal-title":"Am. J. Nephrol."},{"key":"2025030417504297300_r11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417504297300_r12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ki.2015.200","article-title":"Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism","volume":"88","author":"Mehrotra","year":"2015","journal-title":"Kidney Int."},{"key":"2025030417504297300_r13","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.4049\/jimmunol.1502046","article-title":"Chronically elevated levels of short-chain fatty acids induce T cell-mediated ureteritis and hydronephrosis","volume":"196","author":"Park","year":"2016","journal-title":"J. Immunol."},{"key":"2025030417504297300_r14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/path.4430","article-title":"IL-17A produced by both \u03b3\u03b4 T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction","volume":"235","author":"Peng","year":"2015","journal-title":"J. Pathol."},{"key":"2025030417504297300_r15","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1038\/s41598-017-04162-1","article-title":"Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target","volume":"7","author":"Marangoni","year":"2017","journal-title":"Sci. Rep."},{"key":"2025030417504297300_r16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/path.4108","article-title":"Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis","volume":"229","author":"Ariel","year":"2013","journal-title":"J. Pathol."},{"key":"2025030417504297300_r17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025030417504297300_r18","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/ni1537","article-title":"Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10","volume":"8","author":"Stumhofer","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025030417504297300_r19","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/ni1540","article-title":"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. [Published erratum appears in 2008 Nat. Immunol. 9: 105.]","volume":"8","author":"Fitzgerald","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025030417504297300_r20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ajpath.2010.10.013","article-title":"The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses","volume":"178","author":"Summers","year":"2011","journal-title":"Am. J. Pathol."},{"key":"2025030417504297300_r21","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.89","article-title":"In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis","volume":"45","author":"Moon","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"2025030417504297300_r22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004110","article-title":"Timed action of IL-27 protects from immunopathology while preserving defense in influenza","volume":"10","author":"Liu","year":"2014","journal-title":"PLoS Pathog."},{"key":"2025030417504297300_r23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.imbio.2006.05.008","article-title":"Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1","volume":"211","author":"R\u00fcckerl","year":"2006","journal-title":"Immunobiology"},{"key":"2025030417504297300_r24","doi-asserted-by":"crossref","first-page":"e1006173","DOI":"10.1371\/journal.ppat.1006173","article-title":"IL-27 limits type 2 immunopathology following parainfluenza virus infection","volume":"13","author":"Muallem","year":"2017","journal-title":"PLoS Pathog."},{"key":"2025030417504297300_r25","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.4049\/jimmunol.1401322","article-title":"Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus","volume":"193","author":"Pawaria","year":"2014","journal-title":"J. Immunol."},{"key":"2025030417504297300_r26","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1136\/ard.2007.077537","article-title":"Amelioration of human lupus-like phenotypes in MRL\/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1)","volume":"67","author":"Sugiyama","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"2025030417504297300_r27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2310\/JIM.0b013e3181d88f7b","article-title":"Low level of serum interleukin 27 in patients with systemic lupus erythematosus","volume":"58","author":"Li","year":"2010","journal-title":"J. Investig. Med."},{"key":"2025030417504297300_r28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3109\/03009742.2014.962080","article-title":"Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis","volume":"44","author":"Xia","year":"2015","journal-title":"Scand. J. Rheumatol."},{"key":"2025030417504297300_r29","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1074-7613(03)00300-5","article-title":"The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection","volume":"19","author":"Villarino","year":"2003","journal-title":"Immunity"},{"key":"2025030417504297300_r30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1128\/iai.63.3.751-756.1995","article-title":"Roles of gamma interferon and other cytokines in suppression of the spleen cell proliferative response to concanavalin A and toxoplasma antigen during acute toxoplasmosis","volume":"63","author":"Candolfi","year":"1995","journal-title":"Infect. Immun."},{"key":"2025030417504297300_r31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ebiom.2017.09.014","article-title":"Human kidney tubule-specific gene expression based dissection of chronic kidney disease traits","volume":"24","author":"Beckerman","year":"2017","journal-title":"EBioMedicine"},{"key":"2025030417504297300_r32","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/s41591-018-0194-4","article-title":"Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease","volume":"24","author":"Qiu","year":"2018","journal-title":"Nat. Med."},{"key":"2025030417504297300_r33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.aar2131","article-title":"Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease","volume":"360","author":"Park","year":"2018","journal-title":"Science"},{"key":"2025030417504297300_r34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000314578","article-title":"Obstructive uropathy","volume":"169","author":"Truong","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"2025030417504297300_r35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-immunol-032414-112134","article-title":"The immunobiology of interleukin-27","volume":"33","author":"Yoshida","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417504297300_r36","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/sj.ki.5002165","article-title":"Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage","volume":"71","author":"Mori","year":"2007","journal-title":"Kidney Int."},{"key":"2025030417504297300_r37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417504297300_r38","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int."},{"key":"2025030417504297300_r39","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1172\/JCI85782","article-title":"Alternatively activated macrophages determine repair of the infarcted adult murine heart","volume":"126","author":"Shiraishi","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2025030417504297300_r40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004047","article-title":"Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii","volume":"10","author":"Dupont","year":"2014","journal-title":"PLoS Pathog."},{"key":"2025030417504297300_r41","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.4049\/jimmunol.0902874","article-title":"Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts","volume":"183","author":"Rai","year":"2009","journal-title":"J. Immunol."},{"key":"2025030417504297300_r42","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025030417504297300_r43","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/s41385-018-0026-3","article-title":"The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells","volume":"11","author":"Erdmann","year":"2018","journal-title":"Mucosal Immunol."},{"key":"2025030417504297300_r44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI40364","article-title":"Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice","volume":"120","author":"Kovacic","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025030417504297300_r45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molimm.2014.10.021","article-title":"Synergistic effect of pro-inflammatory TNF\u03b1 and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis","volume":"64","author":"Amara","year":"2015","journal-title":"Mol. Immunol."},{"key":"2025030417504297300_r46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clim.2015.10.009","article-title":"Interleukin 17 signaling drives Type I Interferon induced proliferative crescentic glomerulonephritis in lupus-prone mice","volume":"162","author":"Ramani","year":"2016","journal-title":"Clin. Immunol."},{"key":"2025030417504297300_r47","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.4049\/jimmunol.0901942","article-title":"IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2\/monocyte chemoattractant protein-1 induction","volume":"184","author":"Shahrara","year":"2010","journal-title":"J. Immunol."},{"key":"2025030417504297300_r48","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology","volume":"8","author":"McGeachy","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025030417504297300_r49","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1681\/ASN.2014080764","article-title":"Plasma IL-6 and IL-10 concentrations predict AKI and long-term mortality in adults after cardiac surgery","volume":"26","author":"Zhang","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025030417504297300_r50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/s10165-008-0117-1","article-title":"Deficiency in EBV-induced gene 3 (EBI3) in MRL\/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis","volume":"19","author":"Igawa","year":"2009","journal-title":"Mod. Rheumatol."},{"key":"2025030417504297300_r51","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1084\/jem.20101376","article-title":"A novel subset of CD4(+) T(H)2 memory\/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma","volume":"207","author":"Wang","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025030417504297300_r52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/cr.2009.138","article-title":"Heterogeneity and plasticity of T helper cells","volume":"20","author":"Zhu","year":"2010","journal-title":"Cell Res."},{"key":"2025030417504297300_r53","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.1260668","article-title":"T cell immunity. Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines","volume":"347","author":"Becattini","year":"2015","journal-title":"Science"},{"key":"2025030417504297300_r54","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/eji.200939722","article-title":"Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity","volume":"39","author":"Sallusto","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025030417504297300_r55","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/MNH.0000000000000186","article-title":"Monocyte chemoattractant protein-1 and the kidney","volume":"25","author":"Haller","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"2025030417504297300_r56","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.immuni.2012.03.024","article-title":"Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1","volume":"36","author":"Hirahara","year":"2012","journal-title":"Immunity"},{"key":"2025030417504297300_r57","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.imlet.2016.08.002","article-title":"Systemic over-release of interleukin-17 in acute kidney injury after septic shock: clinical and experimental evidence","volume":"178","author":"Maravitsa","year":"2016","journal-title":"Immunol. Lett."},{"key":"2025030417504297300_r58","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5103672","article-title":"IL-17 receptor signaling negatively regulates the development of tubulointerstitial fibrosis in the kidney","volume":"2018","author":"Ramani","year":"2018","journal-title":"Mediators Inflamm."},{"key":"2025030417504297300_r59","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/CIRCRESAHA.112.277525","article-title":"Interleukin-27 receptor limits atherosclerosis in Ldlr-\/- mice","volume":"111","author":"Koltsova","year":"2012","journal-title":"Circ. Res."},{"key":"2025030417504297300_r60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1590\/abd1806-4841.20186123","article-title":"The potential role of Th17 lymphocytes in patients with psoriasis","volume":"93","author":"Mansouri","year":"2018","journal-title":"An. Bras. Dermatol."},{"key":"2025030417504297300_r61","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/cvr\/cvx181","article-title":"Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content","volume":"114","author":"Brauner","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"2025030417504297300_r62","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13104-017-2517-9","article-title":"Expression of mRNA IL-17F and sIL-17F in atopic asthma patients","volume":"10","author":"Hatta","year":"2017","journal-title":"BMC Res. Notes"},{"key":"2025030417504297300_r63","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ckj\/sfw096","article-title":"Macrophage in chronic kidney disease","volume":"9","author":"Guiteras","year":"2016","journal-title":"Clin. Kidney J."},{"key":"2025030417504297300_r64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.kint.2016.08.020","article-title":"IL-4\/IL-13-mediated polarization of renal macrophages\/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury","volume":"91","author":"Zhang","year":"2017","journal-title":"Kidney Int."},{"key":"2025030417504297300_r65","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1007\/s11033-013-2588-1","article-title":"Decreased serum interleukin 27 in Brazilian systemic lupus erythematosus patients","volume":"40","author":"Duarte","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"2025030417504297300_r66","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.4049\/jimmunol.0902999","article-title":"Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection","volume":"184","author":"Deteix","year":"2010","journal-title":"J. Immunol."},{"key":"2025030417504297300_r67","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1159\/000343571","article-title":"Gene polymorphisms of interleukin-17 and interleukin-17 receptor are associated with end-stage kidney disease","volume":"36","author":"Kim","year":"2012","journal-title":"Am. J. Nephrol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/205\/2\/377\/61878733\/ji1901463.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/205\/2\/377\/61878733\/ji1901463.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:58:18Z","timestamp":1741111098000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/205\/2\/377\/7930730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,7,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1901463","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,7]]}}}