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As one of the ultimate hematopoietic organs, the thymus sustains T lymphopoiesis, which is essential for adaptive immune system. However, the mechanism of prethymic T lymphoid progenitors migrating to the thymus remains elusive. In this study, we identify an Rho GTPase Rac2 as a modulator of T lymphoid progenitor homing to the thymus in zebrafish. rac2-Deficient embryos show the inability of T lymphoid progenitors homing to the thymus because of defective cell\u2013autonomous motility. Mechanistically, we demonstrate that Rac2 regulates homing of T lymphoid progenitor through Pak1-mediated AKT pathway. Taken together, our work reveals an important function of Rac2 in directing T lymphoid progenitor migration to the thymus during zebrafish embryogenesis.<\/jats:p>","DOI":"10.4049\/jimmunol.1901494","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:44:27Z","timestamp":1584729867000},"page":"2447-2454","source":"Crossref","is-referenced-by-count":21,"title":["Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-4515","authenticated-orcid":false,"given":"Xinyan","family":"Lu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin 300020 ,","place":["China"]},{"name":"State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin 300020 ,","place":["China"]},{"name":"State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-0943","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin 300020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"2025030417511646000_r1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2006.10.015","article-title":"Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development","volume":"25","author":"Murayama","year":"2006","journal-title":"Immunity"},{"key":"2025030417511646000_r2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cell.2014.12.032","article-title":"Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche","volume":"160","author":"Tamplin","year":"2015","journal-title":"Cell"},{"key":"2025030417511646000_r3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.devcel.2015.07.011","article-title":"Irf4 regulates the choice between T lymphoid-primed progenitor and myeloid lineage fates during embryogenesis","volume":"34","author":"Wang","year":"2015","journal-title":"Dev. 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