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How stable proteins that rely on defective ribosomal proteins for direct presentation are captured for cell-to-cell transfer remains enigmatic. In this study, we address this issue using a combination of in vitro (C57BL\/6-derived mouse cell lines) and in vivo (C57BL\/6 mouse strains) approaches involving stable and unstable versions of OVA model Ags displaying defective ribosomal protein\u2013dependent and \u2013independent Ag presentation, respectively. Apoptosis, but not necrosis, of donor cells was found associated with robust global protein aggregate formation and captured stable proteins permissive for cross-presentation. Potency of aggregates to serve as Ag source was directly demonstrated using polyglutamine-equipped model substrates. Collectively, our data implicate global protein aggregation in apoptotic cells as a mechanism that ensures the overlap between MHC class I epitopes presented directly or cross-presented by APC and demonstrate the unusual ability of dendritic cells to process stable protein aggregates.<\/jats:p>","DOI":"10.4049\/jimmunol.1901535","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T15:25:16Z","timestamp":1602861916000},"page":"2583-2594","source":"Crossref","is-referenced-by-count":3,"title":["Polyglutamine-Related Aggregates Can Serve as a Potent Antigen Source for Cross-Presentation by Dendritic Cells"],"prefix":"10.1093","volume":"205","author":[{"given":"Shira","family":"Tabachnick-Cherny","sequence":"first","affiliation":[{"name":"Department of Biological Regulation, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikla","family":"Berko","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Curato","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-2025","authenticated-orcid":false,"given":"Yochai","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3059-181X","authenticated-orcid":false,"given":"Ziv","family":"Porat","sequence":"additional","affiliation":[{"name":"Department of Biological Services, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotem","family":"Karmona","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8067-6577","authenticated-orcid":false,"given":"Boaz","family":"Tirosh","sequence":"additional","affiliation":[{"name":"The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem , Jerusalem 91120 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-5716","authenticated-orcid":false,"given":"Steffen","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Navon","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, The Weizmann Institute of Science , Rehovot 76100 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"2025030417505568300_r1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/251547a0","article-title":"Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis","volume":"251","author":"Zinkernagel","year":"1974","journal-title":"Nature"},{"key":"2025030417505568300_r2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.immunol.14.1.369","article-title":"Antigen processing and presentation by the class I major histocompatibility complex","volume":"14","author":"York","year":"1996","journal-title":"Annu. 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