{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:27:27Z","timestamp":1789576047959,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005790","name":"Thammasat University","doi-asserted-by":"publisher","award":["26\/2562"],"award-info":[{"award-number":["26\/2562"]}],"id":[{"id":"10.13039\/501100005790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["DPG5980001"],"award-info":[{"award-number":["DPG5980001"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["PHD\/0016\/2558"],"award-info":[{"award-number":["PHD\/0016\/2558"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cryptococcal meningitis is one of the most common life-threatening diseases caused by Cryptococcus infection. Increasing evidence indicates that type 2 immunity is associated with disease progression by promoting fungal growth and dissemination. However, factors that govern this pathogenic response during infection are still elusive. In this study, we investigated the role of IL-25, one of the type 2\u2013inducing cytokines produced by epithelial cells, in contributing to the pathogenesis of cryptococcosis. We found that pulmonary but not systemic infection with a high-virulence strain of C. neoformans significantly induced pulmonary IL-25 expression in the lungs but not brains. In response to pulmonary infection, mice deficient in the surface IL-17 receptor B, a component of the IL-25R, exhibited improved survival with a decreased brain fungal burden. The absence of IL-25R signaling diminished the type 2 and enhanced the type 1 immune response that directed macrophage polarization toward M1 macrophages. Interestingly, Cryptococcus-mediated IL-25 signaling suppressed the expression of cytokines and chemokines associated with protection in the brain, including Ifng, Il1b, Ip10, and Nos2, without affecting brain cellular inflammation and microglia cell activation. Il17rb\u2212\/\u2212 mice receiving cryptococcal-specific CD4+ T cells from wild-type had a shorter survival time with higher fungal burden within the brain and an elevated expression of M2 macrophage markers than those receiving cryptococcal-specific CD4+ T cells from Il17rb\u2212\/\u2212 mice. Taken together, our data indicated that IL-25 signaling subverts the induction of protective immunity and amplifies the type 2 immune response that may favor the development of cryptococcal disease and the fungal dissemination to the CNS.<\/jats:p>","DOI":"10.4049\/jimmunol.2000073","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T18:55:14Z","timestamp":1592592914000},"page":"674-685","source":"Crossref","is-referenced-by-count":23,"title":["IL-25 Receptor Signaling Modulates Host Defense against <i>Cryptococcus neoformans<\/i> Infection"],"prefix":"10.1093","volume":"205","author":[{"given":"Adithap","family":"Hansakon","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University , Pathumthani 12120 ,","place":["Thailand"]},{"name":"Graduate Program in Biomedical Science, Faculty of Allied Health Sciences, Thammasat University , Pathumthani 12120 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siranart","family":"Jeerawattanawart","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University , Pathumthani 12120 ,","place":["Thailand"]},{"name":"Graduate Program in Biomedical Science, Faculty of Allied Health Sciences, Thammasat University , Pathumthani 12120 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kovit","family":"Pattanapanyasat","sequence":"additional","affiliation":[{"name":"Center of Excellence for Flow Cytometry, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok 10700 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-9544","authenticated-orcid":false,"given":"Pornpimon","family":"Angkasekwinai","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University , Pathumthani 12120 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"2025030417504396600_r1","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1097\/QAD.0b013e3282a4a64d","article-title":"HIV-associated cryptococcal meningitis","volume":"21","author":"Jarvis","year":"2007","journal-title":"AIDS"},{"key":"2025030417504396600_r2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"Park","year":"2009","journal-title":"AIDS"},{"key":"2025030417504396600_r3","doi-asserted-by":"crossref","first-page":"17258","DOI":"10.1073\/pnas.0402981101","article-title":"A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)","volume":"101","author":"Kidd","year":"2004","journal-title":"Proc. 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