{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:51:58Z","timestamp":1792414318830,"version":"4.4.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research, Gouvernement du Canada","doi-asserted-by":"publisher","award":["136975"],"award-info":[{"award-number":["136975"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High concentrations of the damage-associated molecular patterns S100A8 and S100A9 are found in skin and serum from patients suffering from psoriasis, an IL-17\u2013related disease. Notably, although the expression of these proteins correlates with psoriatic disease severity, the exact function of S100A8 and S100A9 in psoriasis pathogenesis remains unclear. In this study, we investigated the role of S100A8 and S100A9 in psoriasis-associated skin hyperplasia and immune responses using S100a8\u2212\/\u2212 and S100a9\u2212\/\u2212 mice in an imiquimod-induced model of psoriasis. We found that S100a8\u2212\/\u2212 and S100a9\u2212\/\u2212 psoriatic mice exhibit worsened clinical symptoms relative to wild-type mice and increased expression of S100A9 and S100A8 proteins in keratinocytes, respectively. In addition, the loss of S100A8 enhances proliferation of keratinocytes and disrupts keratinocyte differentiation. We further detected elevated production of IL-17A and -F from CD4+ T cells in the absence of S100A8 and S100A9, as well as increased infiltration of neutrophils in the skin. In addition, treatment with anti\u2013IL-17A and -F was found to reduce psoriasis symptoms and skin hyperplasia in S100a8\u2212\/\u2212 and S100a9\u2212\/\u2212 mice. These data suggest that S100A8 and S100A9 regulate psoriasis by inhibiting production of IL-17A and -F, thereby, to our knowledge, providing new insights into their biological functions.<\/jats:p>","DOI":"10.4049\/jimmunol.2000087","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T21:31:43Z","timestamp":1608759103000},"page":"505-514","source":"Crossref","is-referenced-by-count":37,"title":["Deletion of <i>S100a8<\/i> and <i>S100a9<\/i> Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-5857","authenticated-orcid":false,"given":"Joan","family":"Defr\u00eane","sequence":"first","affiliation":[{"name":"Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiane","family":"Berrazouane","sequence":"additional","affiliation":[{"name":"Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-1903","authenticated-orcid":false,"given":"Nayeli","family":"Esparza","sequence":"additional","affiliation":[{"name":"Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Pag\u00e9","sequence":"additional","affiliation":[{"name":"Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Axe Endocrinologie et N\u00e9phrologie, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Gobeil","sequence":"additional","affiliation":[{"name":"Axe Endocrinologie et N\u00e9phrologie, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]},{"name":"D\u00e9partement de M\u00e9decine Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Quebec City, Quebec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi","family":"Aoudjit","sequence":"additional","affiliation":[{"name":"Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie-Infectiologie et d\u2019Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Quebec City, Quebec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe A","family":"Tessier","sequence":"additional","affiliation":[{"name":"Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie-Infectiologie et d\u2019Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Quebec City, Quebec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"2025022610331130700_r1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"2025022610331130700_r2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"key":"2025022610331130700_r3","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","article-title":"IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes","volume":"174","author":"Boniface","year":"2005","journal-title":"J. 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