{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:52:54Z","timestamp":1777438374755,"version":"3.51.4"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI121250-A1"],"award-info":[{"award-number":["R01 AI121250-A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI 118684"],"award-info":[{"award-number":["T32 AI 118684"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences, NIH","doi-asserted-by":"publisher","award":["T32 GM 008216"],"award-info":[{"award-number":["T32 GM 008216"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005295","name":"American Academy of Pediatrics","doi-asserted-by":"publisher","award":["Marshall Klaus Award"],"award-info":[{"award-number":["Marshall Klaus Award"]}],"id":[{"id":"10.13039\/100005295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006458","name":"Children\u2019s Hospital of Philadelphia","doi-asserted-by":"publisher","award":["Foerderer Award"],"award-info":[{"award-number":["Foerderer Award"]}],"id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","award":["University Research Foundation"],"award-info":[{"award-number":["University Research Foundation"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["Prematurity Research Center"],"award-info":[{"award-number":["Prematurity Research Center"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Disruption in homeostasis of IL-15 is linked to poor maternal and fetal outcomes during pregnancy. The only cells described to respond to IL-15 at the early maternal\u2013fetal interface have been NK cells. We now show a novel population of macrophages, evident in several organs but enriched in the uterus of mice and humans, expressing the \u03b2-chain of the IL-15R complex (CD122) and responding to IL-15. CD122+ macrophages (CD122+Macs) are morphologic, phenotypic, and transcriptomic macrophages that can derive from bone marrow monocytes. CD122+Macs develop in the uterus and placenta with kinetics that mirror IFN activity at the maternal\u2013fetal interface. M-CSF permits macrophages to express CD122, and IFNs are sufficient to drive expression of CD122 on macrophages. Neither type I nor type II IFNs are required to generate CD122+Macs, however. In response to IL-15, CD122+Macs activate the ERK signaling cascade and enhance production of proinflammatory cytokines after stimulation with the TLR9 agonist CpG. Finally, we provide evidence of human cells that phenocopy murine CD122+Macs in secretory phase endometrium during the implantation window and in first-trimester uterine decidua. Our data support a model wherein IFNs local to the maternal\u2013fetal interface direct novel IL-15\u2013responsive macrophages with the potential to mediate IL-15 signals critical for optimal outcomes of pregnancy.<\/jats:p>","DOI":"10.4049\/jimmunol.2000184","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T20:24:41Z","timestamp":1595276681000},"page":"1113-1124","source":"Crossref","is-referenced-by-count":8,"title":["IFNs Drive Development of Novel IL-15\u2013Responsive Macrophages"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-1953","authenticated-orcid":false,"given":"Scott M","family":"Gordon","sequence":"first","affiliation":[{"name":"Division of Neonatology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"},{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-6085","authenticated-orcid":false,"given":"Mailyn A","family":"Nishiguchi","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-3891","authenticated-orcid":false,"given":"Julie M","family":"Chase","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5784-041X","authenticated-orcid":false,"given":"Sneha","family":"Mani","sequence":"additional","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-4791","authenticated-orcid":false,"given":"Monica A","family":"Mainigi","sequence":"additional","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M","family":"Behrens","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Division of Rheumatology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"2025030417504609100_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0378(03)00083-4","article-title":"The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar","volume":"60","author":"Billington","year":"2003","journal-title":"J. Reprod. Immunol."},{"key":"2025030417504609100_r2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.immuni.2018.07.017","article-title":"Interferons and proinflammatory cytokines in pregnancy and fetal development","volume":"49","author":"Yockey","year":"2018","journal-title":"Immunity"},{"key":"2025030417504609100_r3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4049\/jimmunol.171.1.37","article-title":"The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection","volume":"171","author":"Barber","year":"2003","journal-title":"J. Immunol."},{"key":"2025030417504609100_r4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1189\/jlb.0912442","article-title":"Interleukin-15 is required for maximal lipopolysaccharide-induced abortion","volume":"93","author":"Lee","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"2025030417504609100_r5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5830\/CVJA-2016-009","article-title":"Pre-eclampsia: its pathogenesis and pathophysiolgy","volume":"27","author":"Gathiram","year":"2016","journal-title":"Cardiovasc. J. Afr."},{"key":"2025030417504609100_r6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/molehr\/7.1.97","article-title":"Expression profiles of interleukin-15 in early and late gestational human placenta and in pre-eclamptic placenta","volume":"7","author":"Agarwal","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"2025030417504609100_r7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1600-0897.2010.00879.x","article-title":"Placental interleukin-15 expression in recurrent miscarriage","volume":"64","author":"Toth","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025030417504609100_r8","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1084\/jem.184.6.2405","article-title":"The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus","volume":"184","author":"Ye","year":"1996","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1095\/biolreprod63.3.683","article-title":"IL-15 expression at human endometrium and decidua","volume":"63","author":"Kitaya","year":"2000","journal-title":"Biol. Reprod."},{"key":"2025030417504609100_r10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1074-7613(02)00429-6","article-title":"IL-15Ralpha recycles and presents IL-15 in trans to neighboring cells","volume":"17","author":"Dubois","year":"2002","journal-title":"Immunity"},{"key":"2025030417504609100_r11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0162-3109(90)90048-J","article-title":"Resistance of macrophages to 5-fluorouracil treatment","volume":"19","author":"V\u0115tvicka","year":"1990","journal-title":"Immunopharmacology"},{"key":"2025030417504609100_r12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.192.2.259","article-title":"Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy","volume":"192","author":"Ashkar","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r13","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.171.6.2937","article-title":"Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy","volume":"171","author":"Ashkar","year":"2003","journal-title":"J. Immunol."},{"key":"2025030417504609100_r14","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"key":"2025030417504609100_r15","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2025030417504609100_r16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2025030417504609100_r17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"2025030417504609100_r18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cmet.2017.05.018","article-title":"IL-6\/Stat3-Dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis","volume":"26","author":"Theurich","year":"2017","journal-title":"Cell Metab."},{"key":"2025030417504609100_r19","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"key":"2025030417504609100_r20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.immuni.2011.11.016","article-title":"The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation","volume":"36","author":"Gordon","year":"2012","journal-title":"Immunity"},{"key":"2025030417504609100_r21","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.4049\/jimmunol.1500689","article-title":"Composition, development, and function of uterine innate lymphoid cells","volume":"195","author":"Doisne","year":"2015","journal-title":"J. Immunol."},{"key":"2025030417504609100_r22","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1084\/jem.20130903","article-title":"Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium","volume":"210","author":"Schreiber","year":"2013","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r23","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.4049\/jimmunol.1003153","article-title":"Two unique human decidual macrophage populations","volume":"186","author":"Houser","year":"2011","journal-title":"J. Immunol."},{"key":"2025030417504609100_r24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.immuni.2014.08.006","article-title":"Human dermal CD14+ cells are a transient population of monocyte-derived macrophages. [Published erratum appears in 2015 Immunity 42: 391.]","volume":"41","author":"McGovern","year":"2014","journal-title":"Immunity"},{"key":"2025030417504609100_r25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"2025030417504609100_r26","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fimmu.2017.00892","article-title":"CD56 in the immune system: more than a marker for cytotoxicity?","volume":"8","author":"Van Acker","year":"2017","journal-title":"Front. Immunol."},{"key":"2025030417504609100_r27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ni.3341","article-title":"The development and maintenance of resident macrophages","volume":"17","author":"Perdiguero","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025030417504609100_r28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"2025030417504609100_r29","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1084\/jem.20110866","article-title":"Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1","volume":"208","author":"Tagliani","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.immuni.2013.08.007","article-title":"Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes","volume":"39","author":"Jakubzick","year":"2013","journal-title":"Immunity"},{"key":"2025030417504609100_r31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/jemt.10280","article-title":"Granulated metrial gland cells in the murine uterus: localization, kinetics, and the functional role in angiogenesis during pregnancy","volume":"60","author":"Wang","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"2025030417504609100_r32","first-page":"2062","article-title":"Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal\/fetal interface in mice","volume":"119","author":"Collins","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025030417504609100_r33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jlb.50.3.252","article-title":"Determination of the number and distribution of macrophages, lymphocytes, and granulocytes in the mouse uterus from mating through implantation","volume":"50","author":"De","year":"1991","journal-title":"J. Leukoc. Biol."},{"key":"2025030417504609100_r34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/jrf.0.1070265","article-title":"Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice","volume":"107","author":"Robertson","year":"1996","journal-title":"J. Reprod. Fertil."},{"key":"2025030417504609100_r35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/286266a0","article-title":"Identification of an interferon in murine placentas","volume":"286","author":"Fowler","year":"1980","journal-title":"Nature"},{"key":"2025030417504609100_r36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071320","article-title":"IFN-\u03b5 is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines","volume":"8","author":"Hermant","year":"2013","journal-title":"PLoS One"},{"key":"2025030417504609100_r37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/jlb.64.3.393","article-title":"Interferon-gamma gene expression in cycling and pregnant mouse uterus: temporal aspects and cellular localization","volume":"64","author":"Platt","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"2025030417504609100_r38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1126\/science.6606850","article-title":"Endogenous regulation of macrophage proliferative expansion by colony-stimulating factor-induced interferon","volume":"223","author":"Moore","year":"1984","journal-title":"Science"},{"key":"2025030417504609100_r39","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1084\/jem.182.5.1517","article-title":"Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma","volume":"182","author":"Lu","year":"1995","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bone.2006.09.003","article-title":"Macrophage lineage phenotypes and osteoclastogenesis--complexity in the control by GM-CSF and TGF-beta","volume":"40","author":"Lari","year":"2007","journal-title":"Bone"},{"key":"2025030417504609100_r41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1189\/jlb.1108702","article-title":"GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling","volume":"86","author":"Fleetwood","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"2025030417504609100_r42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","article-title":"Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection","volume":"19","author":"Bayer","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2025030417504609100_r43","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.chom.2017.08.012","article-title":"Gestational stage and IFN-\u03bb signaling regulate ZIKV infection in utero","volume":"22","author":"Jagger","year":"2017","journal-title":"Cell Host Microbe"},{"key":"2025030417504609100_r44","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1006\/bbrc.1997.6367","article-title":"Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15","volume":"232","author":"Adunyah","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030417504609100_r45","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.0600240103","article-title":"Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha","volume":"103","author":"Rubinstein","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417504609100_r46","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.4049\/jimmunol.1301389","article-title":"Transcriptional regulation of IL-15 expression during hematopoiesis","volume":"191","author":"Colpitts","year":"2013","journal-title":"J. Immunol."},{"key":"2025030417504609100_r47","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1158\/0008-5472.CAN-14-0637","article-title":"IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers","volume":"74","author":"Marra","year":"2014","journal-title":"Cancer Res."},{"key":"2025030417504609100_r48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0012-1606(91)90336-2","article-title":"A pregnancy defect in the osteopetrotic (op\/op) mouse demonstrates the requirement for CSF-1 in female fertility","volume":"148","author":"Pollard","year":"1991","journal-title":"Dev. Biol."},{"key":"2025030417504609100_r49","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1172\/JCI60561","article-title":"Macrophages regulate corpus luteum development during embryo implantation in mice","volume":"123","author":"Care","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2025030417504609100_r50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","volume":"31","author":"Erlebacher","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417504609100_r51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0897.2006.00446.x","article-title":"Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy","volume":"57","author":"Fest","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025030417504609100_r52","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.4049\/jimmunol.1300490","article-title":"Macrophage-derived IL-33 is a critical factor for placental growth","volume":"191","author":"Fock","year":"2013","journal-title":"J. Immunol."},{"key":"2025030417504609100_r53","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.4049\/jimmunol.1401930","article-title":"Unique roles of infiltrating myeloid cells in the murine uterus during early to midpregnancy","volume":"194","author":"Zhao","year":"2015","journal-title":"J. Immunol."},{"key":"2025030417504609100_r54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","article-title":"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex","volume":"4","author":"Kotenko","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030417504609100_r55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1189\/jlb.0812395","article-title":"Interferon-lambda (IFN-\u03bb) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes","volume":"93","author":"Dickensheets","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"2025030417504609100_r56","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/jir.2010.0078","article-title":"Interferon-lambda: a new addition to an old family","volume":"30","author":"Donnelly","year":"2010","journal-title":"J. Interferon Cytokine Res."},{"key":"2025030417504609100_r57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-0897.1990.tb00652.x","article-title":"Immunohistochemical localization of interferons in human placental tissues in normal, ectopic, and molar pregnancy","volume":"22","author":"Bulmer","year":"1990","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025030417504609100_r58","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1126\/science.1233321","article-title":"Interferon-\u03b5 protects the female reproductive tract from viral and bacterial infection","volume":"339","author":"Fung","year":"2013","journal-title":"Science"},{"key":"2025030417504609100_r59","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1095\/biolreprod61.2.493","article-title":"Interferon-gamma contributes to the normalcy of murine pregnancy","volume":"61","author":"Ashkar","year":"1999","journal-title":"Biol. Reprod."},{"key":"2025030417504609100_r60","first-page":"5062","article-title":"cDNA structures and regulation of two interferon-induced human Mx proteins","volume":"9","author":"Aebi","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"2025030417504609100_r61","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bbrc.2005.02.073","article-title":"Transcriptional regulation of the mouse interleukin-2 receptor beta chain gene by Ets and Egr-1","volume":"329","author":"Ye","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030417504609100_r62","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/intimm\/dxm120","article-title":"Runx proteins are involved in regulation of CD122, Ly49 family and IFN-\u03b3 expression during NK cell differentiation","volume":"20","author":"Ohno","year":"2008","journal-title":"Int. Immunol."},{"key":"2025030417504609100_r63","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. [Published erratum appears in 2006 Nat. Immunol. 7: 113.]","volume":"6","author":"Intlekofer","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025030417504609100_r64","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1084\/jem.164.3.956","article-title":"Regulation of colony-stimulating factor 1 during pregnancy","volume":"164","author":"Bartocci","year":"1986","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r65","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/330484a0","article-title":"Apparent role of the macrophage growth factor, CSF-1, in placental development","volume":"330","author":"Pollard","year":"1987","journal-title":"Nature"},{"key":"2025030417504609100_r66","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.180.4.1395","article-title":"Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor","volume":"180","author":"Carson","year":"1994","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/eji.201343711","article-title":"Human plasma cells express granzyme B","volume":"44","author":"Xu","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"2025030417504609100_r68","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1095\/biolreprod.103.015529","article-title":"Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells","volume":"69","author":"Zhang","year":"2003","journal-title":"Biol. Reprod."},{"key":"2025030417504609100_r69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2011.06.008","article-title":"Alterations in maternal and fetal heart functions accompany failed spiral arterial remodeling in pregnant mice","volume":"205","author":"Zhang","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025030417504609100_r70","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.75351","article-title":"Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model","volume":"1","author":"Sones","year":"2016","journal-title":"JCI Insight"},{"key":"2025030417504609100_r71","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1084\/jem.171.5.1821","article-title":"Expression and role of p75 interleukin 2 receptor on human monocytes","volume":"171","author":"Espinoza-Delgado","year":"1990","journal-title":"J. Exp. Med."},{"key":"2025030417504609100_r72","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0923-2494(92)80077-X","article-title":"The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta chains (p55 and p75)","volume":"143","author":"Scheibenbogen","year":"1992","journal-title":"Res. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/205\/4\/1113\/61879882\/ji2000184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/205\/4\/1113\/61879882\/ji2000184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T18:08:29Z","timestamp":1741111709000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/205\/4\/1113\/7930850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2000184","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,8]]}}}