{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:42:36Z","timestamp":1790890956482,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases, NIH","doi-asserted-by":"publisher","award":["R01AI076457"],"award-info":[{"award-number":["R01AI076457"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases, NIH","doi-asserted-by":"publisher","award":["R21AI137929"],"award-info":[{"award-number":["R21AI137929"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell\u2013mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically regulates CD8 T cell responses is not well studied. In this article, we report a role for cell-intrinsic Batf3 expression in regulating the establishment of circulating and resident memory T cells after foodborne Listeria monocytogenes infection of mice. Consistent with other studies, Batf3 expression by CD8 T cells was dispensable for the primary response. However, Batf3\u2212\/\u2212 T cells underwent increased apoptosis during contraction to contribute to a substantially reduced memory population. Batf3\u2212\/\u2212 memory cells had an impaired ability to mount a robust recall response but remained functional. These findings reveal a cell-intrinsic role of Batf3 in regulating CD8 T cell memory development.<\/jats:p>","DOI":"10.4049\/jimmunol.2000228","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T20:57:37Z","timestamp":1594846657000},"page":"901-906","source":"Crossref","is-referenced-by-count":43,"title":["Cutting Edge: <i>Batf3<\/i> Expression by CD8 T Cells Critically Regulates the Development of Memory Populations"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-7181","authenticated-orcid":false,"given":"Zhijuan","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-9634","authenticated-orcid":false,"given":"Camille","family":"Khairallah","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Romanov","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"2025030417504670300_r1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"2025030417504670300_r2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20091627","article-title":"Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells","volume":"207","author":"Edelson","year":"2010","journal-title":"J. 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Immunol."},{"key":"2025030417504670300_r4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.immuni.2011.08.008","article-title":"CD8\u03b1(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites","volume":"35","author":"Mashayekhi","year":"2011","journal-title":"Immunity"},{"key":"2025030417504670300_r5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.immuni.2011.06.012","article-title":"CD8\u03b1(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes","volume":"35","author":"Edelson","year":"2011","journal-title":"Immunity"},{"key":"2025030417504670300_r6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2016.08.019","article-title":"Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells","volume":"45","author":"Iborra","year":"2016","journal-title":"Immunity"},{"key":"2025030417504670300_r7","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.157","article-title":"The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery","volume":"49","author":"Lee","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"2025030417504670300_r8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0299-y","article-title":"BATF3 is sufficient for the induction of Il9 expression and can compensate for BATF during Th9 cell differentiation","volume":"51","author":"Lee","year":"2019","journal-title":"Exp. Mol. 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