{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:36:31Z","timestamp":1785882991077,"version":"3.56.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["1085240"],"award-info":[{"award-number":["1085240"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It has been reported that a GM-CSF\u2192CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated in the control of inflammatory pain, as well as arthritic pain and disease. We explore, in this study and in various inflammation models, the cellular CCL17 expression and its GM-CSF dependence as well as the function of CCL17 in inflammation and pain. This study used models allowing the convenient cell isolation from Ccl17E\/+ reporter mice; it also exploited both CCL17-dependent and unique CCL17-driven inflammatory pain and arthritis models, the latter permitting a radiation chimera approach to help identify the CCL17 responding cell type(s) and the mediators downstream of CCL17 in the control of inflammation and pain. We present evidence that 1) in the particular inflammation models studied, CCL17 expression is predominantly in macrophage lineage populations and is GM-CSF dependent, 2) for its action in arthritic pain and disease development, CCL17 acts on CCR4+ non\u2013bone marrow\u2013derived cells, and 3) for inflammatory pain development in which a GM-CSF\u2192CCL17 pathway appears critical, nerve growth factor, CGRP, and substance P all appear to be required.<\/jats:p>","DOI":"10.4049\/jimmunol.2000315","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T19:11:40Z","timestamp":1590606700000},"page":"213-222","source":"Crossref","is-referenced-by-count":41,"title":["CCL17 in Inflammation and Pain"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-3524","authenticated-orcid":false,"given":"Kevin M-C","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jarnicki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-2338","authenticated-orcid":false,"given":"Adrian","family":"Achuthan","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Fleetwood","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ellson","sequence":"additional","affiliation":[{"name":"Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage , Hertfordshire SG1 2NY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-2927","authenticated-orcid":false,"given":"Maria","family":"Feeney","sequence":"additional","affiliation":[{"name":"Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage , Hertfordshire SG1 2NY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise K","family":"Modis","sequence":"additional","affiliation":[{"name":"Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage , Hertfordshire SG1 2NY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E","family":"Smith","sequence":"additional","affiliation":[{"name":"Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage , Hertfordshire SG1 2NY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-9224","authenticated-orcid":false,"given":"John A","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]},{"name":"Australian Institute for Musculoskeletal Science, The University of Melbourne and Western Health , St. Albans, Victoria 3021 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2025030417504070200_r1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1182\/blood.V56.6.947.947","article-title":"The nature and action of granulocyte-macrophage colony stimulating factors","volume":"56","author":"Burgess","year":"1980","journal-title":"Blood"},{"key":"2025030417504070200_r2","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.4049\/jimmunol.173.7.4643","article-title":"Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation","volume":"173","author":"Cook","year":"2004","journal-title":"J. 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