{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:37:19Z","timestamp":1783031839359,"version":"3.54.6"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 1660"],"award-info":[{"award-number":["GRK 1660"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1181"],"award-info":[{"award-number":["CRC 1181"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>TNF blockade is a successful treatment for human autoimmune disorders like rheumatoid arthritis and inflammatory bowel disease yet increases susceptibility to tuberculosis and other infections. The C-type lectin receptors (CLR) MINCLE, MCL, and DECTIN-2 are expressed on myeloid cells and sense mycobacterial cell wall glycolipids. In this study, we show that TNF is sufficient to upregulate MINCLE, MCL, and DECTIN-2 in macrophages. TNF signaling through TNFR1 p55 was required for upregulation of these CLR and for cytokine secretion in macrophages stimulated with the MINCLE ligand trehalose-6,6-dibehenate or infected with Mycobacterium bovis bacillus Calmette\u2013Gu\u00e9rin. The Th17 response to immunization with the MINCLE-dependent adjuvant trehalose-6,6-dibehenate was specifically abrogated in TNF-deficient mice and strongly attenuated by TNF blockade with etanercept. Together, interference with production or signaling of TNF antagonized the expression of DECTIN-2 family CLR, thwarting vaccine responses and possibly increasing infection risk.<\/jats:p>","DOI":"10.4049\/jimmunol.2000420","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T19:45:14Z","timestamp":1592250314000},"page":"323-328","source":"Crossref","is-referenced-by-count":20,"title":["Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity"],"prefix":"10.1093","volume":"205","author":[{"given":"Judith","family":"Schick","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-5538","authenticated-orcid":false,"given":"Johanna","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Alexander","sequence":"additional","affiliation":[{"name":"Zellul\u00e4re Mikrobiologie, Forschungszentrum Borstel, Leibniz Lungenzentrum , 23845 Borstel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dichtl","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Biochemistry , 82152 Martinsried ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Murray","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Biochemistry , 82152 Martinsried ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8639","authenticated-orcid":false,"given":"Dennis","family":"Christensen","sequence":"additional","affiliation":[{"name":"Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institute , 2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-6117","authenticated-orcid":false,"given":"Ursula","family":"Sorg","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Krankenhaushygiene, Heinrich Heine Universit\u00e4t D\u00fcsseldorf , 40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Krankenhaushygiene, Heinrich Heine Universit\u00e4t D\u00fcsseldorf , 40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schleicher","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-3677","authenticated-orcid":false,"given":"Roland","family":"Lang","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"2025030417504178900_r1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.4049\/jimmunol.1601665","article-title":"Contact, collaboration, and conflict: signal integration of Syk-coupled C-type lectin receptors","volume":"198","author":"Ostrop","year":"2017","journal-title":"J. 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