{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:14:09Z","timestamp":1776114849594,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Collaborative Research Centre (CRC) 1181"],"award-info":[{"award-number":["Collaborative Research Centre (CRC) 1181"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Siglec-15 is a conserved sialic acid\u2013binding Ig-like lectin, which is expressed on osteoclasts. Deficiency of Siglec-15 leads to an impaired osteoclast development, resulting in a mild osteopetrotic phenotype. The role of Siglec-15 in arthritis is still largely unclear. To address this, we generated Siglec-15 knockout mice and analyzed them in a mouse arthritis model. We could show that Siglec-15 is directly involved in pathologic bone erosion in the K\/BxN serum-transfer arthritis model. Histological analyses of joint destruction provided evidence for a significant reduction in bone erosion area and osteoclast numbers in Siglec-15\u2212\/\u2212 mice, whereas the inflammation area and cartilage destruction was comparable to wild-type mice. Thus, Siglec-15 on osteoclasts has a crucial function for bone erosion during arthritis. In addition, we generated a new monoclonal anti\u2013Siglec-15 Ab to clarify its expression pattern on immune cells. Whereas this Ab demonstrated an almost exclusive Siglec-15 expression on murine osteoclasts and hardly any other expression on various other immune cell types, human Siglec-15 was more broadly expressed on human myeloid cells, including human osteoclasts. Taken together, our findings show a role of Siglec-15 as a regulator of pathologic bone resorption in arthritis and highlight its potential as a target for future therapies, as Siglec-15 blocking Abs are available.<\/jats:p>","DOI":"10.4049\/jimmunol.2000472","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T19:10:18Z","timestamp":1601925018000},"page":"2595-2605","source":"Crossref","is-referenced-by-count":13,"title":["Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis"],"prefix":"10.1093","volume":"205","author":[{"given":"Marina A","family":"Korn","sequence":"first","affiliation":[{"name":"Division of Genetics, Department of Biology, University of Erlangen , 91058 Erlangen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Biology, University of Erlangen , 91058 Erlangen 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