{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:57:27Z","timestamp":1790888247354,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Danish Research Council","award":["DFF - 7016-00310"],"award-info":[{"award-number":["DFF - 7016-00310"]}]},{"DOI":"10.13039\/501100007601","name":"European Union\u2019s Horizon 2020 Framework Programme for Research and Innovation","doi-asserted-by":"publisher","award":["643381"],"award-info":[{"award-number":["643381"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Advanced Small Animal Models for the Testing of Candidate Therapeutic and Preventative Interventions against Mycobacteria","award":["HHSN272201000009I-003"],"award-info":[{"award-number":["HHSN272201000009I-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Despite the fact that the majority of people in tuberculosis (TB)\u2013endemic areas are vaccinated with the Bacillus Calmette\u2013Gu\u00e9rin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis\u2013specific (or \u201cnon-BCG\u201d) subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis\u2013specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis\u2013specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design.<\/jats:p>","DOI":"10.4049\/jimmunol.2000563","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T19:50:11Z","timestamp":1599249011000},"page":"2146-2155","source":"Crossref","is-referenced-by-count":27,"title":["Immunization with <i>Mycobacterium tuberculosis<\/i>\u2013Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette\u2013Gu\u00e9rin Vaccination and Improves Protection in Mice"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-3056","authenticated-orcid":false,"given":"Claus","family":"Aagaard","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-5657","authenticated-orcid":false,"given":"Niels Peter Hell","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iben","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-2330","authenticated-orcid":false,"given":"Angelo A","family":"Izzo","sequence":"additional","affiliation":[{"name":"Colorado State University, Department of Microbiology, Immunology and Pathology , Fort Collins, CO 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-2831","authenticated-orcid":false,"given":"Hongmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine , Seoul 03722 ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Holsey","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7162-8124","authenticated-orcid":false,"given":"Thomas","family":"Lindenstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else Marie","family":"Agger","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-7598","authenticated-orcid":false,"given":"Michael","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"International Reference Laboratory of Mycobacteriology, Statens Serum Institut , DK-2300 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jae","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine , Seoul 03722 ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Rosenkrands","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Immunology, Statens Serum Institut , DK-2300 Copenhagen 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