{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:12:29Z","timestamp":1790471549857,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlamydia trachomatis infection of the female genital tract can lead to irreversible fallopian tube scarring. In the mouse model of genital infection using Chlamydia muridarum, IL-1R signaling plays a critical role in oviduct tissue damage. In this study, we investigated the pathologic role of IL-1\u03b1, one of the two proinflammatory cytokines that bind to IL-1R. Il1a\u2212\/\u2212 mice infected with C. muridarum cleared infection at their cervix at the same rate as wild-type (WT) mice, but were significantly protected from end point oviduct damage and fibrosis. The contribution of IL-1\u03b1 to oviduct pathology was more dramatic than observed in mice deficient for IL-1\u03b2. Although chlamydial burden was similar in WT and Il1a\u2212\/\u2212 oviduct during peak days of infection, levels of IL-1\u03b2, IL-6, CSF3, and CXCL2 were reduced in Il1a\u2212\/\u2212 oviduct lysates. During infection, Il1a\u2212\/\u2212 oviducts and uterine horns exhibited reduced neutrophil infiltration, and this reduction persisted after the infection resolved. The absence of IL-1\u03b1 did not compromise CD4 T cell recruitment or function during primary or secondary chlamydial infection. IL-1\u03b1 is expressed predominantly by luminal cells of the genital tract in response to infection, and low levels of expression persisted after the infection cleared. Ab-mediated depletion of IL-1\u03b1 in WT mice prevented infection-induced oviduct damage, further supporting a key role for IL-1\u03b1 in oviduct pathology.<\/jats:p>","DOI":"10.4049\/jimmunol.2000600","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T19:00:14Z","timestamp":1603306814000},"page":"3037-3049","source":"Crossref","is-referenced-by-count":17,"title":["IL-1\u03b1 Is Essential for Oviduct Pathology during Genital Chlamydial Infection in Mice"],"prefix":"10.1093","volume":"205","author":[{"given":"Clare E","family":"Gyorke","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Kollipara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"John","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-6332","authenticated-orcid":false,"given":"Yugen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-4685","authenticated-orcid":false,"given":"J Ashley","family":"Ezzell","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-2202","authenticated-orcid":false,"given":"Toni","family":"Darville","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-5302","authenticated-orcid":false,"given":"Stephanie A","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-9338","authenticated-orcid":false,"given":"Uma M","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"2025030417505850500_r1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00001432-200402000-00010","article-title":"Tubal factor infertility, with special regard to chlamydial salpingitis","volume":"17","author":"M\u00e5rdh","year":"2004","journal-title":"Curr. 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