{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:28:53Z","timestamp":1781018933245,"version":"3.54.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institutes of Health (NIH)\/National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS057194"],"award-info":[{"award-number":["R01NS057194"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH\/National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM008396"],"award-info":[{"award-number":["GM008396"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Early thymic progenitors (ETPs) are bone marrow\u2013derived hematopoietic stem cells that remain multipotent and give rise to a variety of lineage-specific cells. Recently, we discovered a subset of murine ETPs that expresses the IL-4R\u03b1\/IL-13R\u03b11 heteroreceptor (HR) and commits only to the myeloid lineage. This is because IL-4\/IL-13 signaling through the HR inhibits their T cell potential and enacts commitment of HR+ETPs to thymic resident CD11c+CD8\u03b1+ dendritic cells (DCs). In this study, we discovered that HR+-ETP\u2013derived DCs function as APCs in the thymus and promote deletion of myelin-reactive T cells. Furthermore, this negative T cell selection function of HR+-ETP\u2013derived DCs sustains protection against experimental allergic encephalomyelitis, a mouse model for human multiple sclerosis. These findings, while shedding light on the intricacies underlying ETP lineage commitment, reveal a novel, to our knowledge, function by which IL-4 and IL-13 cytokines condition thymic microenvironment to rheostat T cell selection and fine-tune central tolerance.<\/jats:p>","DOI":"10.4049\/jimmunol.2000614","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T19:45:13Z","timestamp":1599853513000},"page":"2039-2045","source":"Crossref","is-referenced-by-count":3,"title":["Type II Cytokines Fine-Tune Thymic T Cell Selection to Offset Murine Central Nervous System Autoimmunity"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-0434","authenticated-orcid":false,"given":"Subhasis","family":"Barik","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-6575","authenticated-orcid":false,"given":"Alexis N","family":"Cattin-Roy","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-7040","authenticated-orcid":false,"given":"Tobechukwu K","family":"Ukah","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-409X","authenticated-orcid":false,"given":"Mindy M","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-5481","authenticated-orcid":false,"given":"Emma","family":"Teixeiro","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-0050","authenticated-orcid":false,"given":"Habib","family":"Zaghouani","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"2025030417505270300_r1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nature06840","article-title":"The earliest thymic progenitors for T cells possess myeloid lineage potential","volume":"452","author":"Bell","year":"2008","journal-title":"Nature"},{"key":"2025030417505270300_r2","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature06839","article-title":"Adult T-cell progenitors retain myeloid potential","volume":"452","author":"Wada","year":"2008","journal-title":"Nature"},{"key":"2025030417505270300_r3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ni.2255","article-title":"The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential","volume":"13","author":"Luc","year":"2012","journal-title":"Nat. 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