{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:40:22Z","timestamp":1790768422790,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN#154329"],"award-info":[{"award-number":["FDN#154329"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["THC135233"],"award-info":[{"award-number":["THC135233"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI146102"],"award-info":[{"award-number":["R01AI146102"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The NOX2 NADPH oxidase (NOX2) produces reactive oxygen species to kill phagosome-confined bacteria. However, we previously showed that Listeria monocytogenes is able to avoid the NOX2 activity in phagosomes and escape to the cytosol. Thus, despite the established role of NOX2 limiting L. monocytogenes infection in mice, the underlying mechanisms of this antibacterial activity remain unclear. In this article, we report that NOX2 controls systemic L. monocytogenes spread through modulation of the type I IFN response, which is known to be exploited by L. monocytogenes during infection. NOX2 deficiency results in increased expression of IFN-stimulated genes in response to type I IFN and leads to 1) promotion of cell-to-cell spread by L. monocytogenes, 2) defective leukocyte recruitment to infection foci, and 3) production of anti-inflammatory effectors IL-10 and thioredoxin 1. Our findings report a novel antimicrobial role for NOX2 through modulation of type I IFN responses to control bacterial dissemination.<\/jats:p>","DOI":"10.4049\/jimmunol.2000694","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T22:31:50Z","timestamp":1607380310000},"page":"323-328","source":"Crossref","is-referenced-by-count":10,"title":["Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-030X","authenticated-orcid":false,"given":"Jorge David","family":"Rojas M\u00e1rquez","sequence":"first","affiliation":[{"name":"Cell Biology Program, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-9442","authenticated-orcid":false,"given":"Taoyingnan","family":"Li","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R R","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-3786","authenticated-orcid":false,"given":"Joel M J","family":"Tan","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, Ontario M5S 1A1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-3346","authenticated-orcid":false,"given":"Aleixo","family":"Muise","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]},{"name":"Department of Biochemistry, University of Toronto , Toronto, Ontario M5S 1A1 ,","place":["Canada"]},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]},{"name":"SickKids IBD Centre, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-1300","authenticated-orcid":false,"given":"Darren E","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Blavatnik Institute, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5802-7789","authenticated-orcid":false,"given":"John H","family":"Brumell","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A1 ,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, Ontario M5S 1A1 ,","place":["Canada"]},{"name":"SickKids IBD Centre, Hospital for Sick Children , Toronto, Ontario M5G 0A4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2025022610325899800_r1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00281-010-0221-0","article-title":"The many roles of NOX2 NADPH oxidase-derived ROS in immunity","volume":"32","author":"Lam","year":"2010","journal-title":"Semin. 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