{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:29:17Z","timestamp":1792132157073,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-derived products to host cells. Extracellular membrane vesicles (MVs) secreted from symbiont commensals represent one such transport mechanism. How MVs exert their anti-inflammatory effects or whether their tolerance-inducing potential can be used for therapeutic purposes remains poorly defined. In this study, we show that MVs isolated from the human lactic acid commensal bacteria Pediococcus pentosaceus suppressed Ag-specific humoral and cellular responses. MV treatment of bone marrow\u2013derived macrophages and bone marrow progenitors promoted M2-like macrophage polarization and myeloid-derived suppressor cell differentiation, respectively, most likely in a TLR2-dependent manner. Consistent with their immunomodulatory activity, MV-differentiated cells upregulated expression of IL-10, arginase-1, and PD-L1 and suppressed the proliferation of activated T cells. MVs\u2019 anti-inflammatory effects were further tested in acute inflammation models in mice. In carbon tetrachloride\u2013induced fibrosis and zymosan-induced peritonitis models, MVs ameliorated inflammation. In the dextran sodium sulfate\u2013induced acute colitis model, systemic treatment with MVs prevented colon shortening and loss of crypt architecture. In an excisional wound healing model, i.p. MV administration accelerated wound closure through recruitment of PD-L1\u2013expressing myeloid cells to the wound site. Collectively, these results indicate that P. pentosaceus\u2013derived MVs hold promise as therapeutic agents in management\/treatment of inflammatory conditions.<\/jats:p>","DOI":"10.4049\/jimmunol.2000731","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T15:30:11Z","timestamp":1602084611000},"page":"2707-2718","source":"Crossref","is-referenced-by-count":66,"title":["Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells"],"prefix":"10.1093","volume":"205","author":[{"given":"Esin","family":"Alpdundar Bulut","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Middle East Technical University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-3717","authenticated-orcid":false,"given":"Banu","family":"Bayyurt Kocabas","sequence":"additional","affiliation":[{"name":"Therapeutic Oligodeoxynucleotide Research Laboratory, Department of Molecular Biology and Genetics, Ihsan Dogramaci Bilkent University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-0181","authenticated-orcid":false,"given":"Volkan","family":"Yazar","sequence":"additional","affiliation":[{"name":"Therapeutic Oligodeoxynucleotide Research Laboratory, Department of Molecular Biology and Genetics, Ihsan Dogramaci Bilkent University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-8628","authenticated-orcid":false,"given":"Gamze","family":"Aykut","sequence":"additional","affiliation":[{"name":"Therapeutic Oligodeoxynucleotide Research Laboratory, Department of Molecular Biology and Genetics, Ihsan Dogramaci Bilkent University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulku","family":"Guler","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hacettepe University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-6531","authenticated-orcid":false,"given":"Bekir","family":"Salih","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hacettepe University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naz","family":"Surucu Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Middle East Technical University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-1401","authenticated-orcid":false,"given":"Ihsan Cihan","family":"Ayanoglu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Middle East Technical University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-485X","authenticated-orcid":false,"given":"Muammer Merve","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, Yuksek Ihtisas University , Ankara 06520 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil Can","family":"Akcali","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine, Ankara University , Ankara 06100 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan","family":"Gursel","sequence":"additional","affiliation":[{"name":"Therapeutic Oligodeoxynucleotide Research Laboratory, Department of Molecular Biology and Genetics, Ihsan Dogramaci Bilkent University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-9054","authenticated-orcid":false,"given":"Mayda","family":"Gursel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Middle East Technical University , Ankara 06800 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"2025030417505680700_r1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. 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