{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:25:17Z","timestamp":1790807117831,"version":"4.1.0"},"reference-count":103,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["2016-06592"],"award-info":[{"award-number":["2016-06592"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["154332"],"award-info":[{"award-number":["154332"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The thymus is an intricate primary lymphoid organ, wherein bone marrow\u2013derived lymphoid progenitor cells are induced to develop into functionally competent T cells that express a diverse TCR repertoire, which is selected to allow for the recognition of foreign Ags while avoiding self-reactivity or autoimmunity. Thymus stromal cells, which can include all non\u2013T lineage cells, such as thymic epithelial cells, endothelial cells, mesenchymal\/fibroblast cells, dendritic cells, and B cells, provide signals that are essential for thymocyte development as well as for the homeostasis of the thymic stroma itself. In this brief review, we focus on the key roles played by thymic stromal cells during early stages of T cell development, such as promoting the homing of thymic-seeding progenitors, inducing T lineage differentiation, and supporting thymocyte survival and proliferation. We also discuss recent advances on the transcriptional regulation that govern thymic epithelial cell function as well as the cellular and molecular changes that are associated with thymic involution and regeneration.<\/jats:p>","DOI":"10.4049\/jimmunol.2000889","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T22:30:26Z","timestamp":1609799426000},"page":"249-256","source":"Crossref","is-referenced-by-count":65,"title":["A 2020 View of Thymus Stromal Cells in T Cell Development"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-5297","authenticated-orcid":false,"given":"Jianxun","family":"Han","sequence":"first","affiliation":[{"name":"Sunnybrook Research Institute , Toronto, Ontario M4N 3M5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-3178","authenticated-orcid":false,"given":"Juan Carlos","family":"Z\u00fa\u00f1iga-Pfl\u00fccker","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute , Toronto, Ontario M4N 3M5 ,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2025022610330325400_r1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.23.021704.115715","article-title":"Zoned out: functional mapping of stromal signaling microenvironments in the thymus","volume":"25","author":"Petrie","year":"2007","journal-title":"Annu. 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