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In this study, we identified the protective role of IL-27\/IL-27R in host defense against Chlamydia muridarum respiratory infection and further investigated the immunological mechanism. Our results showed that IL-27 was involved in C. muridarum infection and that IL-27R knockout mice (WSX-1\u2013\/\u2013 mice) suffered more severe disease, with greater body weight loss, higher chlamydial loads, and more severe inflammatory reactions in the lungs than C57BL\/6 wild-type mice. There were excessive IL-17\u2013producing CD4+ T cells and many more neutrophils, neutrophil-related proteins, cytokines, and chemokines in the lungs of WSX-1\u2013\/\u2013 mice than in wild-type mice following C. muridarum infection. In addition, IL-17\/IL-17A\u2013blocking Ab treatment improved disease after C. muridarum infection in WSX-1\u2013\/\u2013 mice. Overall, we conclude that IL-27\/IL-27R mediates protective immunity during chlamydial respiratory infection in mice by suppressing excessive Th17 responses and reducing neutrophil inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.2000957","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T15:04:36Z","timestamp":1618585476000},"page":"2160-2169","source":"Crossref","is-referenced-by-count":19,"title":["IL-27\/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-656X","authenticated-orcid":false,"given":"Xiaoyu","family":"Zha","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China , Tianjin 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