{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:20:09Z","timestamp":1789662009712,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630084"],"award-info":[{"award-number":["81630084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation Incubation Program of the Second Affiliated Hospital of Anhui Medical University","award":["2019GQFY06"],"award-info":[{"award-number":["2019GQFY06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitamin D deficiency is associated with increased risks of chronic obstructive pulmonary disease (COPD). Nevertheless, the mechanisms remain unknown. This study analyzed the correlations between vitamin D levels and inflammation in COPD patients. One hundred and one patients with COPD and 202 control subjects were enrolled. Serum 25(OH)D level and inflammatory cytokines were detected. Serum 25(OH)D was decreased and inflammatory cytokines were increased in COPD patients. According to forced expiratory volume in 1 s, COPD patients were divided into three grades. Furthermore, serum 25(OH)D was gradually decreased in COPD patients ranging from grade 1\u20132 to 4. Serum 25(OH)D was inversely associated with inflammatory cytokines in COPD patients. Further analysis found that NF-\u03baB and AP-1 signaling were activated in COPD patients. Besides, inflammatory signaling was gradually increased in parallel with the severity of COPD. By contrast, pulmonary nuclear vitamin D receptor was decreased in COPD patients. In vitro experiments showed that 1,25(OH)2D3 inhibited LPS-activated inflammatory signaling in A549 cells (human lung adenocarcinoma cell). Mechanically, 1,25(OH)2D3 reinforced physical interactions between vitamin D receptor with NF-\u03baB p65 and c-Jun. Our results indicate that vitamin D is inversely correlated with inflammatory signaling in COPD patients. Inflammation may be a vital mediator of COPD progress in patients with low vitamin D levels.<\/jats:p>","DOI":"10.4049\/jimmunol.2000964","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T16:32:32Z","timestamp":1608741152000},"page":"515-523","source":"Crossref","is-referenced-by-count":69,"title":["Low Vitamin D Status Is Associated with Inflammation in Patients with Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"206","author":[{"given":"Lin","family":"Fu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital, Anhui Medical University , Hefei 230032 ,","place":["China"]},{"name":"Department of Toxicology, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fei","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Xia","family":"Tan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-4436","authenticated-orcid":false,"given":"Yuan-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Anhui Medical University , Hefei 230032 ,","place":["China"]},{"name":"Department of Histology and Embryology, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Hu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Xiang","family":"Xiang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"2025022610331445200_r1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am. 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