{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:04:39Z","timestamp":1792897479793,"version":"4.5.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":1486,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Age-related chronic inflammation promotes cellular senescence, chronic disease, cancer, and reduced lifespan. In this study, we wanted to explore the effects of a moderate exercise regimen on inflammatory liver disease and tumorigenesis. We used an established model of spontaneous inflammaging, steatosis, and cancer (nfkb1\u2212\/\u2212 mouse) to demonstrate whether 3 mo of moderate aerobic exercise was sufficient to suppress liver disease and cancer development. Interventional exercise when applied at a relatively late disease stage was effective at reducing tissue inflammation (liver, lung, and stomach), oxidative damage, and cellular senescence, and it reversed hepatic steatosis and prevented tumor development. Underlying these benefits were transcriptional changes in enzymes driving the conversion of tryptophan to NAD+, this leading to increased hepatic NAD+ and elevated activity of the NAD+-dependent deacetylase sirtuin. Increased SIRT activity was correlated with enhanced deacetylation of key transcriptional regulators of inflammation and metabolism, NF-\u03baB (p65), and PGC-1\u03b1. We propose that moderate exercise can effectively reprogram pre-established inflammatory and metabolic pathologies in aging with the benefit of prevention of disease.<\/jats:p>","DOI":"10.4049\/jimmunol.2001022","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T18:21:49Z","timestamp":1610562109000},"page":"904-916","source":"Crossref","is-referenced-by-count":42,"title":["Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis"],"prefix":"10.1093","volume":"206","author":[{"given":"Arianna","family":"Bianchi","sequence":"first","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-4063","authenticated-orcid":false,"given":"Letizia","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Hall","sequence":"additional","affiliation":[{"name":"Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London , London SW7 2AZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-3283","authenticated-orcid":false,"given":"Henrique","family":"Lemos","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-224X","authenticated-orcid":false,"given":"Michele","family":"Vacca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge , Cambridge CB2 1QW ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Paish","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kile","family":"Green","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronte","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, University of Sheffield , Sheffield S10 2TN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Tiniakos","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o F","family":"Passos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-0857","authenticated-orcid":false,"given":"Diana","family":"Jurk","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A","family":"Mann","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9016-6025","authenticated-orcid":false,"given":"Caroline L","family":"Wilson","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"2025030501505377300_r1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/hep.26465","article-title":"Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients","volume":"58","author":"Noureddin","year":"2013","journal-title":"Hepatology"},{"key":"2025030501505377300_r2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"2025030501505377300_r3","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1093\/nar\/gkm893","article-title":"DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?","volume":"35","author":"Passos","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2025030501505377300_r4","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat. Commun."},{"key":"2025030501505377300_r5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2025030501505377300_r6","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cmet.2016.05.007","article-title":"Exercise promotes healthy aging of skeletal muscle","volume":"23","author":"Cartee","year":"2016","journal-title":"Cell Metab."},{"key":"2025030501505377300_r7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.6061\/clinics\/2013(05)20","article-title":"Exercise training as a preventive tool for age-related disorders: a brief review","volume":"68","author":"Ciolac","year":"2013","journal-title":"Clinics (S\u00e3o Paulo)"},{"key":"2025030501505377300_r8","first-page":"130","article-title":"Exercise, inflammation and aging","volume":"3","author":"Woods","year":"2012","journal-title":"Aging Dis."},{"key":"2025030501505377300_r9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1477-7525-5-68","article-title":"Physical activity as a mediator of the impact of chronic conditions on quality of life in older adults","volume":"5","author":"Sawatzky","year":"2007","journal-title":"Health Qual. Life Outcomes"},{"key":"2025030501505377300_r10","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1038\/ncomms5172","article-title":"Chronic inflammation induces telomere dysfunction and accelerates ageing in mice","volume":"2","author":"Jurk","year":"2014","journal-title":"Nat. Commun."},{"key":"2025030501505377300_r11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0092-8674(95)90415-8","article-title":"Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses","volume":"80","author":"Sha","year":"1995","journal-title":"Cell"},{"key":"2025030501505377300_r12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.bbagrm.2018.09.001","article-title":"HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression","volume":"1861","author":"Cartwright","year":"2018","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"2025030501505377300_r13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jhep.2010.03.025","article-title":"The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes","volume":"53","author":"Elsharkawy","year":"2010","journal-title":"J. Hepatol."},{"key":"2025030501505377300_r14","doi-asserted-by":"crossref","first-page":"6818","DOI":"10.1038\/ncomms7818","article-title":"NF\u03baB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. [Published erratum appears in 2015 Nat. Commun. 6: 8411.]","volume":"6","author":"Wilson","year":"2015","journal-title":"Nat. Commun."},{"key":"2025030501505377300_r15","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jaci.2016.10.054","article-title":"Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes","volume":"140","author":"Kaustio","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025030501505377300_r16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jaci.2018.01.039","article-title":"Loss-of-function nuclear factor \u03baB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans","volume":"142","author":"Tuijnenburg","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025030501505377300_r17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jcmgh.2018.11.006","article-title":"NFKB1 and MANBA confer disease susceptibility to primary biliary cholangitis via independent putative primary functional variants","volume":"7","author":"Hitomi","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"2025030501505377300_r18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1084\/jem.20151182","article-title":"NF\u03baB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells","volume":"213","author":"de Valle","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025030501505377300_r19","first-page":"570","article-title":"Loss of NF-\u03baB1 causes gastric cancer with aberrant inflammation and expression of immune checkpoint regulators in a STAT-1-dependent manner","volume-title":"Immunity","author":"O\u2019Reilly","year":"2018"},{"key":"2025030501505377300_r20","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology."},{"key":"2025030501505377300_r21","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.4049\/jimmunol.0901150","article-title":"The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse","volume":"185","author":"Hoshi","year":"2010","journal-title":"J. Immunol."},{"key":"2025030501505377300_r22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"2025030501505377300_r23","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/ac051437y","article-title":"XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification","volume":"78","author":"Smith","year":"2006","journal-title":"Anal. Chem."},{"key":"2025030501505377300_r24","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1152\/japplphysiol.01061.2011","article-title":"Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury","volume":"112","author":"de Ara\u00fajo","year":"2012","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2025030501505377300_r25","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1158\/1078-0432.CCR-13-2590","article-title":"Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers","volume":"20","author":"Di Caro","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"2025030501505377300_r26","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/ni.3290","article-title":"Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma","volume":"16","author":"Finkin","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025030501505377300_r27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nri3700","article-title":"Ectopic lymphoid-like structures in infection, cancer and autoimmunity","volume":"14","author":"Pitzalis","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025030501505377300_r28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ajpath.2011.03.007","article-title":"Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling","volume":"179","author":"Coppola","year":"2011","journal-title":"Am. J. Pathol."},{"key":"2025030501505377300_r29","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"2025030501505377300_r30","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/acel.12128","article-title":"Liver diseases and aging: friends or foes?","volume":"12","author":"Sheedfar","year":"2013","journal-title":"Aging Cell"},{"key":"2025030501505377300_r31","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1242\/jcs.073783","article-title":"SIRT2 regulates NF-\u03baB dependent gene expression through deacetylation of p65 Lys310. [Published erratum appears in 2019 J. Cell Sci. 132: jcs232801.]","volume":"123","author":"Rothgiesser","year":"2010","journal-title":"J. Cell Sci."},{"key":"2025030501505377300_r32","article-title":"SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-\u03baB activity","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"2025030501505377300_r33","article-title":"The acetylation of RelA in Lys310 dictates the NF-\u03baB-dependent response in post-ischemic injury. [Published erratum appears in 2010 Cell. Death Dis. 1: e107.]","volume":"1","author":"Lanzillotta","year":"2010","journal-title":"Cell Death Dis."},{"key":"2025030501505377300_r34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2014.07.051","article-title":"Skeletal muscle PGC-1\u03b11 modulates kynurenine metabolism and mediates resilience to stress-induced depression","volume":"159","author":"Agudelo","year":"2014","journal-title":"Cell"},{"key":"2025030501505377300_r35","doi-asserted-by":"crossref","first-page":"E145","DOI":"10.1152\/ajpendo.00755.2009","article-title":"PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity","volume":"299","author":"Lira","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2025030501505377300_r36","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fphys.2018.00636","article-title":"Moderate exercise suppresses NF-\u03baB signaling and activates the SIRT1-AMPK-PGC1\u03b1 axis to attenuate muscle loss in diabetic db\/db mice","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"key":"2025030501505377300_r37","first-page":"148","article-title":"Selective chemical inhibition of PGC-1\u03b1 Gluconeogenic activity ameliorates type 2 diabetes","volume-title":"Cell","author":"Sharabi","year":"2017"},{"key":"2025030501505377300_r38","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cmet.2014.04.001","article-title":"NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease","volume":"19","author":"Cerutti","year":"2014","journal-title":"Cell Metab."},{"key":"2025030501505377300_r39","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00125-019-4831-3","article-title":"NAD+ metabolism as a target for metabolic health: have we found the silver bullet?","volume":"62","author":"Connell","year":"2019","journal-title":"Diabetologia"},{"key":"2025030501505377300_r40","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2741\/4283","article-title":"Calorie restriction and NAD+\/sirtuin counteract the hallmarks of aging","volume":"19","author":"Michan","year":"2014","journal-title":"Front. Biosci."},{"key":"2025030501505377300_r41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic potential of NAD-boosting molecules: the in vivo evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab."},{"key":"2025030501505377300_r42","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aac4854","article-title":"NAD+ in aging, metabolism, and neurodegeneration","volume":"350","author":"Verdin","year":"2015","journal-title":"Science"},{"key":"2025030501505377300_r43","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrendo.2015.117","article-title":"Physiological and pathophysiological roles of NAMPT and NAD metabolism","volume":"11","author":"Garten","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"2025030501505377300_r44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jshs.2012.07.009","article-title":"Chronic disease and the link to physical activity","volume":"2","author":"Durstine","year":"2013","journal-title":"J. Sport Health Sci."},{"key":"2025030501505377300_r45","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease","volume":"11","author":"Gleeson","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025030501505377300_r46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/1559827607300283","article-title":"The anti-inflammatory actions of exercise training","volume":"1","author":"Flynn","year":"2007","journal-title":"Am. J. Lifestyle Med."},{"key":"2025030501505377300_r47","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00421-017-3667-0","article-title":"T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans","volume":"117","author":"Clifford","year":"2017","journal-title":"Eur. J. Appl. Physiol."},{"key":"2025030501505377300_r48","first-page":"34","article-title":"Exercise and toll-like receptors","volume":"12","author":"Gleeson","year":"2006","journal-title":"Exerc. Immunol. Rev."},{"key":"2025030501505377300_r49","first-page":"105","article-title":"Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice","volume":"16","author":"Kawanishi","year":"2010","journal-title":"Exerc. Immunol. Rev."},{"key":"2025030501505377300_r50","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1055\/s-2007-985898","article-title":"Inflammation, obesity, and the metabolic syndrome","volume":"39","author":"Yudkin","year":"2007","journal-title":"Horm. Metab. Res."},{"key":"2025030501505377300_r51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1600-065X.1982.tb00431.x","article-title":"Corticosteroid-mediated immunoregulation in man","volume":"65","author":"Cupps","year":"1982","journal-title":"Immunol. Rev."},{"key":"2025030501505377300_r52","first-page":"6","article-title":"Interleukin-6 in acute exercise and training: what is the biological relevance?","volume":"12","author":"Fischer","year":"2006","journal-title":"Exerc. Immunol. Rev."},{"key":"2025030501505377300_r53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019194","article-title":"Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats","volume":"6","author":"Braidy","year":"2011","journal-title":"PLoS One"},{"key":"2025030501505377300_r54","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat. Commun."},{"key":"2025030501505377300_r55","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien","year":"2011","journal-title":"Genes Dev."},{"key":"2025030501505377300_r56","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","article-title":"Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP)","volume":"24","author":"Salminen","year":"2012","journal-title":"Cell. Signal."},{"key":"2025030501505377300_r57","first-page":"1067","article-title":"Quantitative analysis of NAD synthesis-breakdown fluxes","volume-title":"Cell Metab.","author":"Liu","year":"2018"},{"key":"2025030501505377300_r58","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"2025030501505377300_r59","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2010.06.009","article-title":"Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis","volume":"12","author":"Kim","year":"2010","journal-title":"Cell Metab."},{"key":"2025030501505377300_r60","doi-asserted-by":"crossref","first-page":"17312","DOI":"10.1074\/jbc.M117.778720","article-title":"Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3","volume":"292","author":"Kwon","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2025030501505377300_r61","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.febslet.2010.11.047","article-title":"SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model","volume":"585","author":"Wang","year":"2011","journal-title":"FEBS Lett."},{"key":"2025030501505377300_r62","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ceb.2008.03.012","article-title":"Transcriptional targets of sirtuins in the coordination of mammalian physiology","volume":"20","author":"Feige","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"2025030501505377300_r63","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1158\/1535-7163.MCT-15-0621","article-title":"The role of PGC1\u03b1 in cancer metabolism and its therapeutic implications","volume":"15","author":"Tan","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"2025030501505377300_r64","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3390\/cancers11121949","article-title":"The roles of sirtuin family proteins in cancer progression","volume":"11","author":"Zhao","year":"2019","journal-title":"Cancers (Basel)"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/206\/4\/904\/61433617\/ji2001022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/206\/4\/904\/61433617\/ji2001022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T01:51:59Z","timestamp":1741139519000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/206\/4\/904\/7953723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2001022","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2021,2]]}}}