{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:16:01Z","timestamp":1778400961216,"version":"3.51.4"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009053","name":"Wellcome Trust\/Department of Biotechnology India Alliance","doi-asserted-by":"publisher","award":["IA\/I\/15\/2\/502061"],"award-info":[{"award-number":["IA\/I\/15\/2\/502061"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology\/Ministry of Science and Technology","doi-asserted-by":"publisher","award":["SR\/FST\/LS-II\/2018\/217"],"award-info":[{"award-number":["SR\/FST\/LS-II\/2018\/217"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology\/Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"Katholieke Universiteit Leuven","doi-asserted-by":"publisher","award":["IDO\/13\/016 HSC-Niche"],"award-info":[{"award-number":["IDO\/13\/016 HSC-Niche"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0E0117N"],"award-info":[{"award-number":["G0E0117N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Outside-in integrin signaling regulates cell fate decisions in a variety of cell types, including hematopoietic stem cells (HSCs). Our earlier published studies showed that interruption of periostin (POSTN) and integrin-\u03b1v (ITGAV) interaction induces faster proliferation in HSCs with developmental stage\u2013dependent functional effects. In this study, we examined the role of POSTN\u2013ITGAV axis in lymphohematopoietic activity in spleen that hosts a rare population of HSCs, the functional regulation of which is not clearly known. Vav-iCre\u2013mediated deletion of Itgav in the hematopoietic system led to higher proliferation rates, resulting in increased frequency of primitive HSCs in the adult spleen. However, in vitro CFU-C assays demonstrated a poorer differentiation potential following Itgav deletion. This also led to a decrease in the white pulp area with a significant decline in the B cell numbers. Systemic deletion of its ligand, POSTN, phenocopied the effects noted in Vav-Itgav\u2212\/\u2212 mice. Histological examination of Postn-deficient spleen also showed an increase in the spleen trabecular areas. Importantly, these are the myofibroblasts of the trabecular and capsular areas that expressed high levels of POSTN within the spleen tissue. In addition, vascular smooth muscle cells also expressed POSTN. Through CFU-S12 assays, we showed that hematopoietic support potential of stroma in Postn-deficient splenic hematopoietic niche was defective. Overall, we demonstrate that POSTN\u2013ITGAV interaction plays an important role in spleen lymphohematopoiesis.<\/jats:p>","DOI":"10.4049\/jimmunol.2001066","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T10:50:33Z","timestamp":1614336633000},"page":"1549-1560","source":"Crossref","is-referenced-by-count":8,"title":["Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4869-848X","authenticated-orcid":false,"given":"Shubham Haribhau","family":"Mehatre","sequence":"first","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram , Kerala 695551 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9858-1207","authenticated-orcid":false,"given":"Irene Mariam","family":"Roy","sequence":"additional","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram , Kerala 695551 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atreyi","family":"Biswas","sequence":"additional","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram , Kerala 695551 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devila","family":"Prit","sequence":"additional","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram , Kerala 695551 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Schouteden","sequence":"additional","affiliation":[{"name":"Interdepartmental Stem Cell Institute, Katholieke Universiteit Leuven , 3000 Leuven ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Huelsken","sequence":"additional","affiliation":[{"name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne , 1015 Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M","family":"Verfaillie","sequence":"additional","affiliation":[{"name":"Interdepartmental Stem Cell Institute, Katholieke Universiteit Leuven , 3000 Leuven ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5176-1510","authenticated-orcid":false,"given":"Satish","family":"Khurana","sequence":"additional","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram , Kerala 695551 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"2025030417255014700_r1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev-pathol-012615-044414","article-title":"Hematopoietic stem cell niche in health and disease","volume":"11","author":"Hoggatt","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"2025030417255014700_r2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417255014700_r3","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0301-472X(02)00881-0","article-title":"Roles of spleen and liver in development of the murine hematopoietic system","volume":"30","author":"Wolber","year":"2002","journal-title":"Exp. Hematol."},{"key":"2025030417255014700_r4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3892\/mmr.2015.4621","article-title":"Extramedullary hematopoiesis: elucidating the function of the hematopoietic stem cell niche (Review)","volume":"13","author":"Yamamoto","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"2025030417255014700_r5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/0300985811432344","article-title":"Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals","volume":"49","author":"Johns","year":"2012","journal-title":"Vet. Pathol."},{"key":"2025030417255014700_r6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.20141642","article-title":"Macrophages retain hematopoietic stem cells in the spleen via VCAM-1","volume":"212","author":"Dutta","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025030417255014700_r7","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1083\/jcb.128.6.1243","article-title":"The integrin VLA-4 supports tethering and rolling in flow on VCAM-1","volume":"128","author":"Alon","year":"1995","journal-title":"J. Cell Biol."},{"key":"2025030417255014700_r8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/352438a0","article-title":"Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions","volume":"352","author":"Williams","year":"1991","journal-title":"Nature"},{"key":"2025030417255014700_r9","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1182\/blood-2008-10-184721","article-title":"BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells","volume":"114","author":"Ramirez","year":"2009","journal-title":"Blood"},{"key":"2025030417255014700_r10","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1182\/blood.V90.12.4779","article-title":"Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice","volume":"90","author":"Craddock","year":"1997","journal-title":"Blood"},{"key":"2025030417255014700_r11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1189\/jlb.69.3.307","article-title":"Regulation of hematopoiesis through adhesion receptors","volume":"69","author":"Prosper","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"2025030417255014700_r12","doi-asserted-by":"crossref","first-page":"13500","DOI":"10.1038\/ncomms13500","article-title":"Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis","volume":"7","author":"Khurana","year":"2016","journal-title":"Nat. Commun."},{"key":"2025030417255014700_r13","doi-asserted-by":"crossref","first-page":"9647","DOI":"10.1073\/pnas.92.21.9647","article-title":"The VLA4\/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen","volume":"92","author":"Papayannopoulou","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417255014700_r14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(00)80216-2","article-title":"Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow","volume":"12","author":"Potocnik","year":"2000","journal-title":"Immunity"},{"key":"2025030417255014700_r15","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood-2004-11-4422","article-title":"Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells","volume":"106","author":"Nilsson","year":"2005","journal-title":"Blood"},{"key":"2025030417255014700_r16","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1084\/jem.20041992","article-title":"Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size","volume":"201","author":"Stier","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030417255014700_r17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10555-007-9104-9","article-title":"Osteopontin: regulation in tumor metastasis","volume":"27","author":"Wai","year":"2008","journal-title":"Cancer Metastasis Rev."},{"key":"2025030417255014700_r18","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1007\/s00018-017-2648-0","article-title":"Periostin in inflammation and allergy","volume":"74","author":"Izuhara","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"2025030417255014700_r19","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.15252\/embj.201796771","article-title":"Integrin \u03b1v\u03b23 enhances the suppressive effect of interferon-\u03b3 on hematopoietic stem cells","volume":"36","author":"Umemoto","year":"2017","journal-title":"EMBO J."},{"key":"2025030417255014700_r20","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1172\/JCI43796","article-title":"\u03b1v Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice","volume":"120","author":"Acharya","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025030417255014700_r21","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1172\/JCI58978","article-title":"Periostin promotes chronic allergic inflammation in response to Th2 cytokines","volume":"122","author":"Masuoka","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2025030417255014700_r22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.exphem.2010.12.008","article-title":"Functional characterization of hematopoietic stem cells in the spleen","volume":"39","author":"Morita","year":"2011","journal-title":"Exp. Hematol."},{"key":"2025030417255014700_r23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature10694","article-title":"Interactions between cancer stem cells and their niche govern metastatic colonization","volume":"481","author":"Malanchi","year":"2011","journal-title":"Nature"},{"key":"2025030417255014700_r24","doi-asserted-by":"crossref","first-page":"15823","DOI":"10.1073\/pnas.0707421104","article-title":"Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins","volume":"104","author":"Lacy-Hulbert","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417255014700_r25","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/immu.200310005","article-title":"Transgenic mice with hematopoietic and lymphoid specific expression of Cre","volume":"33","author":"de Boer","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025030417255014700_r26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2004.07.004","article-title":"Tie2\/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche","volume":"118","author":"Arai","year":"2004","journal-title":"Cell"},{"key":"2025030417255014700_r27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2307\/3570892","article-title":"A direct measurement of the radiation sensitivity of normal mouse bone marrow cells","volume":"14","author":"Till","year":"1961","journal-title":"Radiat. Res."},{"key":"2025030417255014700_r28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000813","article-title":"Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7","volume":"6","author":"Phillips","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025030417255014700_r29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.it.2011.11.001","article-title":"CD169+ macrophages at the crossroads of antigen presentation","volume":"33","author":"Martinez-Pomares","year":"2012","journal-title":"Trends Immunol."},{"key":"2025030417255014700_r30","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.stemcr.2020.06.022","article-title":"The periostin\/integrin-\u03b1v axis regulates the size of hematopoietic stem cell pool in the fetal liver","volume":"15","author":"Biswas","year":"2020","journal-title":"Stem Cell Reports"},{"key":"2025030417255014700_r31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/343170a0","article-title":"Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis","volume":"343","author":"Savill","year":"1990","journal-title":"Nature"},{"key":"2025030417255014700_r32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0955-0674(00)00252-0","article-title":"Adhesion events in angiogenesis","volume":"13","author":"Eliceiri","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"2025030417255014700_r33","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1128\/MCB.23.24.9349-9360.2003","article-title":"Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing","volume":"23","author":"Scott","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2025030417255014700_r34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/380171a0","article-title":"Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins","volume":"380","author":"Hirsch","year":"1996","journal-title":"Nature"},{"key":"2025030417255014700_r35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood-2005-10-4209","article-title":"The differentiation program of embryonic definitive hematopoietic stem cells is largely alpha4 integrin independent","volume":"108","author":"Gribi","year":"2006","journal-title":"Blood"},{"key":"2025030417255014700_r36","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1182\/blood-2010-06-293506","article-title":"Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen","volume":"116","author":"Manevich-Mendelson","year":"2010","journal-title":"Blood"},{"key":"2025030417255014700_r37","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1182\/blood-2010-08-301119","article-title":"In vitro requirement for periostin in B lymphopoiesis","volume":"117","author":"Siewe","year":"2011","journal-title":"Blood"},{"key":"2025030417255014700_r38","first-page":"5358","article-title":"Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility","volume":"62","author":"Gillan","year":"2002","journal-title":"Cancer Res."},{"key":"2025030417255014700_r39","first-page":"A2064","article-title":"Alphambeta2 integrin-mediated adhesion and motility of Interleukin-5-stimulated eosinophils on periostin","volume":"187","author":"Johansson","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025030417255014700_r40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI115000","article-title":"Coupling of the adhesive receptor CD11b\/CD18 to functional enhancement of effector macrophage tissue factor response","volume":"87","author":"Fan","year":"1991","journal-title":"J. Clin. Invest."},{"key":"2025030417255014700_r41","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1016\/S0021-9258(18)98430-9","article-title":"Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption","volume":"268","author":"Ross","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2025030417255014700_r42","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ni.3791","article-title":"Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin","volume":"18","author":"Kanayama","year":"2017","journal-title":"Nat. Immunol."},{"key":"2025030417255014700_r43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12079-010-0090-2","article-title":"Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation","volume":"4","author":"Zhou","year":"2010","journal-title":"J. Cell Commun. Signal."},{"key":"2025030417255014700_r44","doi-asserted-by":"crossref","first-page":"12260","DOI":"10.1038\/ncomms12260","article-title":"Genetic lineage tracing defines myofibroblast origin and function in the injured heart","volume":"7","author":"Kanisicak","year":"2016","journal-title":"Nat. Commun."},{"key":"2025030417255014700_r45","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.stem.2013.10.010","article-title":"Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies","volume":"13","author":"Joseph","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2025030417255014700_r46","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/hepr.13195","article-title":"Pathological findings that contribute to tissue stiffness in the spleen of liver cirrhosis patients","volume":"48","author":"Kondo","year":"2018","journal-title":"Hepatol. Res."},{"key":"2025030417255014700_r47","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature15530","article-title":"A perisinusoidal niche for extramedullary haematopoiesis in the spleen","volume":"527","author":"Inra","year":"2015","journal-title":"Nature"},{"key":"2025030417255014700_r48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2141.1999.01294.x","article-title":"Spleen stromal cells support haemopoiesis and in vitro growth of dendritic cells from bone marrow","volume":"105","author":"Ni","year":"1999","journal-title":"Br. J. Haematol."},{"key":"2025030417255014700_r49","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.exphem.2009.06.001","article-title":"Splenic stromal niches support hematopoiesis of dendritic-like cells from precursors in bone marrow and spleen","volume":"37","author":"Periasamy","year":"2009","journal-title":"Exp. Hematol."},{"key":"2025030417255014700_r50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2019.00001","article-title":"Identification of stromal cells in spleen which support myelopoiesis","volume":"7","author":"Lim","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"2025030417255014700_r51","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1440-1746.2002.02667.x","article-title":"Role of the spleen in liver fibrosis in rats may be mediated by transforming growth factor beta-1","volume":"17","author":"Akahoshi","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2025030417255014700_r52","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","article-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta","volume":"14","author":"Horiuchi","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"2025030417255014700_r53","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1073\/pnas.1009426107","article-title":"Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma","volume":"107","author":"Sidhu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417255014700_r54","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.185.4.755","article-title":"Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice","volume":"185","author":"Peters","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025030417255014700_r55","first-page":"a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume-title":"Cold Spring Harb. Perspect. Biol.","author":"Tanaka","year":"2014"},{"key":"2025030417255014700_r56","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20101643","article-title":"Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation","volume":"208","author":"Takizawa","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025030417255014700_r57","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1182\/blood-2017-06-780882","article-title":"Inflammation: a key regulator of hematopoietic stem cell fate in health and disease","volume":"130","author":"Pietras","year":"2017","journal-title":"Blood"},{"key":"2025030417255014700_r58","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.celrep.2019.12.075","article-title":"Periostin promotes colorectal tumorigenesis through integrin-FAK-src pathway-mediated YAP\/TAZ activation","volume":"30","author":"Ma","year":"2020","journal-title":"Cell Rep."},{"key":"2025030417255014700_r59","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/jid.2013.500","article-title":"Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1\u03b1\/IL-6 loop","volume":"134","author":"Taniguchi","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"2025030417255014700_r60","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/1523-1747.ep12483971","article-title":"Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6","volume":"97","author":"Duncan","year":"1991","journal-title":"J. Invest. Dermatol."},{"key":"2025030417255014700_r61","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1182\/blood.V87.5.1780.1780","article-title":"Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis","volume":"87","author":"Lowell","year":"1996","journal-title":"Blood"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/206\/7\/1549\/61878013\/ji2001066.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/206\/7\/1549\/61878013\/ji2001066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T12:27:07Z","timestamp":1741091227000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/206\/7\/1549\/7944223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2001066","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.11.236083","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4]]},"published":{"date-parts":[[2021,4,1]]}}}