{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:42:37Z","timestamp":1789537357450,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI068129"],"award-info":[{"award-number":["AI068129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI100874"],"award-info":[{"award-number":["AI100874"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Heterogeneity among naive adaptive lymphocytes determines their individual functions and fate decisions during an immune response. NK cells are innate lymphocytes capable of generating \u201cadaptive\u201d responses during infectious challenges. However, the factors that govern various NK cell functions are not fully understood. In this study, we use a reporter mouse model to permanently \u201ctime stamp\u201d NK cells and type 1 innate lymphoid cells (ILC1s) to characterize the dynamics of their homeostatic turnover. We found that the homeostatic turnover of tissue-resident ILC1s is much slower than that of circulating NK cells. NK cell homeostatic turnover is further accelerated without the transcription factor Eomes. Finally, heterogeneity in NK cell age diversifies NK cell function, with \u201colder\u201d NK cells exhibiting more potent IFN-\u03b3 production to activating stimuli and more robust adaptive responses during CMV infection. These results provide insight into how the functional response of an NK cell varies over its lifespan.<\/jats:p>","DOI":"10.4049\/jimmunol.2001163","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T18:08:25Z","timestamp":1608746905000},"page":"465-470","source":"Crossref","is-referenced-by-count":15,"title":["Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5751-0480","authenticated-orcid":false,"given":"Nicholas M","family":"Adams","sequence":"first","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9735-2253","authenticated-orcid":false,"given":"Carlos","family":"Diaz-Salazar","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center , New York, NY 10065"},{"name":"Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-1835","authenticated-orcid":false,"given":"Celeste","family":"Dang","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center , New York, NY 10065"},{"name":"Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-3952","authenticated-orcid":false,"given":"Lewis L","family":"Lanier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of California, San Francisco , San Francisco, CA 94143"},{"name":"Parker Institute for Cancer Immunotherapy , San Francisco, CA 94129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-9033","authenticated-orcid":false,"given":"Joseph C","family":"Sun","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center , New York, NY 10065"},{"name":"Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College , New York, NY 10065"},{"name":"Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"2025022610331713300_r1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/46218","article-title":"Selecting and maintaining a diverse T-cell repertoire","volume":"402","author":"Goldrath","year":"1999","journal-title":"Nature"},{"key":"2025022610331713300_r2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cell.2018.05.029","article-title":"Developmental origin governs CD8 + T cell fate decisions during infection","volume":"174","author":"Smith","year":"2018","journal-title":"Cell"},{"key":"2025022610331713300_r3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nri3028","article-title":"Post-thymic maturation: young T cells assert their individuality","volume":"11","author":"Fink","year":"2011","journal-title":"Nat. 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