{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:17:42Z","timestamp":1791505062558,"version":"4.3.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010661","name":"EC | Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["734548"],"award-info":[{"award-number":["734548"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as a global concern because of its impact on human health. ZIKV infection during pregnancy can cause microcephaly and other severe brain defects in the developing fetus and there have been reports of the occurrence of Guillain-Barr\u00e9 syndrome in areas affected by ZIKV. NK cells are activated during acute viral infections and their activity contributes to a first line of defense because of their ability to rapidly recognize and kill virus-infected cells. To provide insight into NK cell function during ZIKV infection, we have profiled, using mass cytometry, the NK cell receptor-ligand repertoire in a cohort of acute ZIKV-infected female patients. Freshly isolated NK cells from these patients contained distinct, activated, and terminally differentiated, subsets expressing higher levels of CD57, NKG2C, and KIR3DL1 as compared with those from healthy donors. Moreover, KIR3DL1+ NK cells from these patients produced high levels of IFN-\u03b3 and TNF-\u03b1, in the absence of direct cytotoxicity, in response to in vitro stimulation with autologous, ZIKV-infected, monocyte-derived dendritic cells. In ZIKV-infected patients, overproduction of IFN-\u03b3 correlated with STAT-5 activation (r = 0.6643; p = 0.0085) and was mediated following the recognition of MHC class 1\u2013related chain A and chain B molecules expressed by ZIKV-infected monocyte-derived dendritic cells, in synergy with IL-12 production by the latter cells. Together, these findings suggest that NK cells contribute to the generation of an efficacious adaptive anti-ZIKV immune response that could potentially affect the outcome of the disease and\/or the development of persistent symptoms.<\/jats:p>","DOI":"10.4049\/jimmunol.2001180","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T15:55:20Z","timestamp":1629302120000},"page":"1333-1343","source":"Crossref","is-referenced-by-count":14,"title":["NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-2992","authenticated-orcid":false,"given":"Christopher","family":"Maucourant","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, UPMC, Inserm U1135, CNRS ERL 8255, Centre d\u2019Immunologie et des Maladies Infectieuses , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Andrade","family":"Nonato Queiroz","sequence":"additional","affiliation":[{"name":"FIOCRUZ , Salvador ,","place":["Brazil"]},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica , Salvador ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-6872","authenticated-orcid":false,"given":"Aurelien","family":"Corneau","sequence":"additional","affiliation":[{"name":"UPMC Univ Paris 06, Plateforme de Cytom\u00e9trie, UMS30\u2013LUMIC, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, Site Piti\u00e9-Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-3558","authenticated-orcid":false,"given":"Luana","family":"Leandro Gois","sequence":"additional","affiliation":[{"name":"FIOCRUZ , Salvador ,","place":["Brazil"]},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica , Salvador ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7440-5495","authenticated-orcid":false,"given":"Aida","family":"Meghraoui-Kheddar","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, UPMC, Inserm U1135, CNRS ERL 8255, Centre d\u2019Immunologie et des Maladies Infectieuses , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, UPMC, Inserm U1135, CNRS ERL 8255, Centre d\u2019Immunologie et des Maladies Infectieuses , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Bandeira","sequence":"additional","affiliation":[{"name":"FIOCRUZ , Salvador ,","place":["Brazil"]},{"name":"Secretaria de Sa\u00fade da Bahia , Salvador, Bahia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2610-9915","authenticated-orcid":false,"given":"Assia","family":"Samri","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, UPMC, Inserm U1135, CNRS ERL 8255, Centre d\u2019Immunologie et des Maladies Infectieuses , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-7417","authenticated-orcid":false,"given":"Catherine","family":"Blanc","sequence":"additional","affiliation":[{"name":"UPMC Univ Paris 06, Plateforme de Cytom\u00e9trie, UMS30\u2013LUMIC, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, Site Piti\u00e9-Salp\u00eatri\u00e8re , Paris 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Infectieuses , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"2025022610320835100_r1","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/S1473-3099(16)30010-X","article-title":"Zika virus: history of a newly emerging arbovirus","volume":"16","author":"Wikan","year":"2016","journal-title":"Lancet Infect. 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Hyg."},{"key":"2025022610320835100_r3","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/S0140-6736(17)31450-2","article-title":"An update on Zika virus infection","volume":"390","author":"Baud","year":"2017","journal-title":"Lancet"},{"key":"2025022610320835100_r4","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barr\u00e9 Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","volume":"387","author":"Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"key":"2025022610320835100_r5","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1056\/NEJMc1609015","article-title":"Zika virus and the Guillain-Barr\u00e9 Syndrome\u2014Case series from seven countries","volume":"375","author":"Dos Santos","year":"2016","journal-title":"N. Engl. J. 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