{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:06:37Z","timestamp":1790370397444,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI125651"],"award-info":[{"award-number":["R01 AI125651"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI069197"],"award-info":[{"award-number":["U01 AI069197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with a T cell\u2013like gene profile, including the canonical markers CD3\u03b5, CD5, and CD8\u03b2, as well as the T cell lineage\u2013commitment transcription factor Bcl11b. Although Bcl11b expression is upregulated during NK maturation from CD56bright to CD56dim, we find a Bcl11b-mediated signature at the protein level for Fc\u03b5RI\u03b3, PLZF, IL-2R\u03b2, CD3\u03b3, CD3\u03b4, and CD3\u03b5 in later-stage, HCMV-induced NK cells. BCL11B is targeted by Notch signaling in T cell development, and culture of NK cells with Notch ligand increases cytoplasmic CD3\u03b5 expression. The Bcl11b-mediated gain of CD3\u03b5, physically associated with CD16 signaling molecules Lck and CD247 in NK cells is correlated with increased Ab-dependent effector function, including against HCMV-infected cells, identifying a potential mechanism for their prevalence in HCMV-infected individuals and their prospective clinical use in Ab-based therapies.<\/jats:p>","DOI":"10.4049\/jimmunol.2001319","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T15:41:13Z","timestamp":1633707673000},"page":"2534-2544","source":"Crossref","is-referenced-by-count":19,"title":["Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature"],"prefix":"10.1093","volume":"207","author":[{"given":"Zeguang","family":"Wu","sequence":"first","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-094X","authenticated-orcid":false,"given":"Colleen M","family":"Lau","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-9508","authenticated-orcid":false,"given":"Rosa","family":"Sottile","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Beno\u00eet","family":"Le Luduec","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-1164","authenticated-orcid":false,"given":"M Kazim","family":"Panjwani","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-3827","authenticated-orcid":false,"given":"Peter M","family":"Conaty","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-3230","authenticated-orcid":false,"given":"Katja","family":"Srpan","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Laib Sampaio","sequence":"additional","affiliation":[{"name":"Institute of Virology, Ulm University Medical Center , Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4944-3182","authenticated-orcid":false,"given":"Thomas","family":"Mertens","sequence":"additional","affiliation":[{"name":"Institute of Virology, Ulm University Medical Center , Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart P","family":"Adler","sequence":"additional","affiliation":[{"name":"CMV Research Foundation, Inc. , Richmond, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann B","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health & Science University , Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet N","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Kong V","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-9033","authenticated-orcid":false,"given":"Joseph C","family":"Sun","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan\u2013Kettering Cancer Center , New York, NY"},{"name":"Louis V. 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