{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:34:41Z","timestamp":1775165681893,"version":"3.50.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06751"],"award-info":[{"award-number":["16H06751"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08232"],"award-info":[{"award-number":["18K08232"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K08222"],"award-info":[{"award-number":["21K08222"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophils protect against bacterial and fungal infections, but tight regulation of cell activation is essential for avoiding tissue damage in autoimmune disorders. Protein kinase R (PKR) is a serine\/threonine kinase originally characterized by its role in the defense mechanisms against viral infection. Although PKR is involved in the signaling pathways of neurodegenerative diseases and metabolic disorders, its function in neutrophils is not well delineated. In this study, we demonstrate that human neutrophil PKR mediates adhesion to endothelial cells under physiological flow conditions but does not mediate rolling on those cells. Also, neutrophil PKR activation contributes to migration toward chemoattractants. Mechanistically, neutrophil PKR mediates the cell spreading and binding to ICAM-1 in static condition. Moreover, Ab microarray reveals that calcium\/calmodulin-dependent protein kinase II is phosphorylated downstream of PKR and affects actin polymerization that is a cytoskeleton rearrangement indispensable for neutrophil migration induced by fMLF. In vivo, neutrophil recruitment into the dorsal air pouch of mice is reduced by PKR inhibitor treatment. Also, in mice with nephrotoxic serum nephritis, the compound treatment suppresses neutrophil accumulation in kidney glomerulus and subsequent development of albuminuria. Thus, in vascular inflammation, neutrophil PKR plays a critical role in the recruitment process, including endothelial adhesion and migration via leukocyte actin polymerization.<\/jats:p>","DOI":"10.4049\/jimmunol.2001349","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T14:00:37Z","timestamp":1649426437000},"page":"2173-2183","source":"Crossref","is-referenced-by-count":4,"title":["Neutrophil Protein Kinase R Mediates Endothelial Adhesion and Migration by the Promotion of Neutrophil Actin Polymerization"],"prefix":"10.1093","volume":"208","author":[{"given":"Reiko","family":"Inoue","sequence":"first","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nishi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuko","family":"Osaka","sequence":"additional","affiliation":[{"name":"Department of Life Science and Bioethics, Graduate School of Medicine, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-4504","authenticated-orcid":false,"given":"Masayuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Life Science and Bioethics, Graduate School of Medicine, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7401-2934","authenticated-orcid":false,"given":"Masaomi","family":"Nangaku","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"key":"2025021009050035400_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2353\/ajpath.2008.070502","article-title":"Mechanisms and consequences of neutrophil interaction with the endothelium","volume":"172","author":"Zarbock","year":"2008","journal-title":"Am. J. Pathol."},{"key":"2025021009050035400_r2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025021009050035400_r3","doi-asserted-by":"crossref","first-page":"eaat4579","DOI":"10.1126\/sciimmunol.aat4579","article-title":"Neutrophils: new insights and open questions","volume":"3","author":"Ley","year":"2018","journal-title":"Sci. Immunol."},{"key":"2025021009050035400_r4","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.162.2.1120","article-title":"Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck","volume":"162","author":"M\u00f3csai","year":"1999","journal-title":"J. Immunol."},{"key":"2025021009050035400_r5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(02)00303-5","article-title":"Syk is required for integrin signaling in neutrophils","volume":"16","author":"M\u00f3csai","year":"2002","journal-title":"Immunity"},{"key":"2025021009050035400_r6","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1172\/JCI94039","article-title":"Neutrophil Fc\u03b3RIIA promotes IgG-mediated glomerular neutrophil capture via Abl\/Src kinases","volume":"127","author":"Nishi","year":"2017","journal-title":"J. Clin. Invest."},{"key":"2025021009050035400_r7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/bph.14090","article-title":"PRN473, an inhibitor of Bruton\u2019s tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling","volume":"175","author":"Herter","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"2025021009050035400_r8","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.4049\/jimmunol.1600604","article-title":"PTPN22 is a critical regulator of Fc\u03b3 receptor-mediated neutrophil activation","volume":"197","author":"Vermeren","year":"2016","journal-title":"J. Immunol."},{"key":"2025021009050035400_r9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1189\/jlb.4A0915-405R","article-title":"PKC-\u03b4 activation in neutrophils promotes fungal clearance","volume":"100","author":"Li","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"2025021009050035400_r10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1089\/jir.1997.17.503","article-title":"The double-stranded RNA-dependent protein kinase PKR: structure and function","volume":"17","author":"Clemens","year":"1997","journal-title":"J. Interferon Cytokine Res."},{"key":"2025021009050035400_r11","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1073\/pnas.91.14.6288","article-title":"Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B","volume":"91","author":"Kumar","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021009050035400_r12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0014-4827(76)90632-7","article-title":"In vitro myogenesis. Expression of muscle specific function in the absence of cell fusion","volume":"97","author":"Merlie","year":"1976","journal-title":"Exp. Cell Res."},{"key":"2025021009050035400_r13","doi-asserted-by":"crossref","first-page":"e47721","DOI":"10.1371\/journal.pone.0047721","article-title":"Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"2025021009050035400_r14","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.3892\/ol.2014.2560","article-title":"Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinoma cells by activating STAT3","volume":"8","author":"Wang","year":"2014","journal-title":"Oncol. Lett."},{"key":"2025021009050035400_r15","doi-asserted-by":"crossref","first-page":"53459","DOI":"10.18632\/oncotarget.10557","article-title":"Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling","volume":"7","author":"Yuan","year":"2016","journal-title":"Oncotarget"},{"key":"2025021009050035400_r16","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1074\/jbc.M109.041954","article-title":"Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice","volume":"285","author":"Couturier","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2025021009050035400_r17","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.cell.2011.11.029","article-title":"Suppression of PKR promotes network excitability and enhanced cognition by interferon-\u03b3-mediated disinhibition","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"},{"key":"2025021009050035400_r18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13195-017-0308-0","article-title":"PKR involvement in Alzheimer\u2019s disease","volume":"9","author":"Hugon","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"2025021009050035400_r19","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1210\/en.2012-1400","article-title":"Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice","volume":"153","author":"Carvalho-Filho","year":"2012","journal-title":"Endocrinology"},{"key":"2025021009050035400_r20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2337\/db13-1019","article-title":"Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice","volume":"63","author":"Nakamura","year":"2014","journal-title":"Diabetes"},{"key":"2025021009050035400_r21","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1093\/emboj\/19.14.3630","article-title":"Potential role of PKR in double-stranded RNA-induced macrophage activation","volume":"19","author":"Maggi","year":"2000","journal-title":"EMBO J."},{"key":"2025021009050035400_r22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1096\/fj.09-140053","article-title":"Novel role for the double-stranded RNA-activated protein kinase PKR: modulation of macrophage infection by the protozoan parasite Leishmania","volume":"24","author":"Pereira","year":"2010","journal-title":"FASEB J."},{"key":"2025021009050035400_r23","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nature11290","article-title":"Novel role of PKR in inflammasome activation and HMGB1 release","volume":"488","author":"Lu","year":"2012","journal-title":"Nature"},{"key":"2025021009050035400_r24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2014.02.012","article-title":"PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis","volume":"270","author":"Kapil","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"2025021009050035400_r25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41389-018-0058-2","article-title":"Neutrophil TLR4 and PKR are targets of breast cancer cell glycosaminoglycans and effectors of glycosaminoglycan-induced APRIL secretion","volume":"7","author":"Bat-Erdene","year":"2018","journal-title":"Oncogenesis"},{"key":"2025021009050035400_r26","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood.V70.5.1233.1233","article-title":"The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression","volume":"70","author":"Collins","year":"1987","journal-title":"Blood"},{"key":"2025021009050035400_r27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-2567.2005.02131.x","article-title":"Neutrophil differentiated HL-60 cells model Mac-1 (CD11b\/CD18)-independent neutrophil transepithelial migration","volume":"115","author":"Carrigan","year":"2005","journal-title":"Immunology"},{"key":"2025021009050035400_r28","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/hq0701.092143","article-title":"Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism","volume":"21","author":"Yoshida","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025021009050035400_r29","doi-asserted-by":"crossref","first-page":"38869","DOI":"10.1074\/jbc.M110.166686","article-title":"Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin","volume":"285","author":"Ito","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2025021009050035400_r30","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1182\/blood-2011-08-373118","article-title":"Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation","volume":"119","author":"Lefort","year":"2012","journal-title":"Blood"},{"key":"2025021009050035400_r31","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.20160647","article-title":"Skap2 is required for \u03b22 integrin-mediated neutrophil recruitment and functions","volume":"214","author":"Boras","year":"2017","journal-title":"J. Exp. Med."},{"key":"2025021009050035400_r32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/path.1711340205","article-title":"The formation of a structure with the features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system","volume":"134","author":"Edwards","year":"1981","journal-title":"J. Pathol."},{"key":"2025021009050035400_r33","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1681\/ASN.2014030289","article-title":"Sirtuin1 maintains actin cytoskeleton by deacetylation of cortactin in injured podocytes","volume":"26","author":"Motonishi","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025021009050035400_r34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ajpath.2010.11.011","article-title":"Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions","volume":"178","author":"Nishi","year":"2011","journal-title":"Am. J. Pathol."},{"key":"2025021009050035400_r35","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri3908","article-title":"How leukocytes cross the vascular endothelium","volume":"15","author":"Vestweber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"2025021009050035400_r36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.115.3.453","article-title":"The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes","volume":"115","author":"Boyden","year":"1962","journal-title":"J. Exp. Med."},{"key":"2025021009050035400_r37","first-page":"15","article-title":"Boyden chamber assay","volume":"294","author":"Chen","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"2025021009050035400_r38","doi-asserted-by":"crossref","first-page":"e12966","DOI":"10.1111\/eci.12966","article-title":"Intracellular \u03b22 integrin (CD11\/CD18) interacting partners in neutrophil trafficking","volume":"48","author":"Thome","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"2025021009050035400_r39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fimmu.2019.00254","article-title":"Beta2-integrins and interacting proteins in leukocyte trafficking, immune suppression, and immunodeficiency disease","volume":"10","author":"Fagerholm","year":"2019","journal-title":"Front. Immunol."},{"key":"2025021009050035400_r40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.116.1.219","article-title":"Divalent cation regulation of the function of the leukocyte integrin LFA-1","volume":"116","author":"Dransfield","year":"1992","journal-title":"J. Cell Biol."},{"key":"2025021009050035400_r41","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.3389\/fimmu.2018.03115","article-title":"CCR7 is recruited to the immunological synapse, acts as co-stimulatory molecule and drives LFA-1 clustering for efficient t cell adhesion through ZAP70","volume":"9","author":"Laufer","year":"2019","journal-title":"Front. Immunol."},{"key":"2025021009050035400_r42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1189\/jlb.3A0916-388RR","article-title":"TNF induces neutrophil adhesion via formin-dependent cytoskeletal reorganization and activation of \u03b2-integrin function","volume":"103","author":"Silveira","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"2025021009050035400_r43","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1083\/jcb.99.3.1060","article-title":"Chemotactic peptide-induced changes in neutrophil actin conformation","volume":"99","author":"Wallace","year":"1984","journal-title":"J. Cell Biol."},{"key":"2025021009050035400_r44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.115.3.677","article-title":"Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution","volume":"115","author":"Cano","year":"1991","journal-title":"J. Cell Biol."},{"key":"2025021009050035400_r45","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.4049\/jimmunol.1402414","article-title":"Tetraspanin CD37 regulates \u03b22 integrin-mediated adhesion and migration in neutrophils","volume":"195","author":"Wee","year":"2015","journal-title":"J. Immunol."},{"key":"2025021009050035400_r46","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1182\/blood.2019002633","article-title":"MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization","volume":"135","author":"Sprenkeler","year":"2020","journal-title":"Blood"},{"key":"2025021009050035400_r47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.immunol.021908.132554","article-title":"The ins and outs of leukocyte integrin signaling","volume":"27","author":"Abram","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"2025021009050035400_r48","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1046\/j.1432-1033.2002.03162.x","article-title":"Role of Ca2+\/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase","volume":"269","author":"Verploegen","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"2025021009050035400_r49","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1096\/fj.14-265215","article-title":"Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin","volume":"29","author":"Steinckwich","year":"2015","journal-title":"FASEB J."},{"key":"2025021009050035400_r50","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1182\/blood-2009-05-224659","article-title":"Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow","volume":"115","author":"Schaff","year":"2010","journal-title":"Blood"},{"key":"2025021009050035400_r51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.apha.2016.08.003","article-title":"Ca2+\/calmodulin-dependent protein kinase II in vascular smooth muscle","volume":"78","author":"Saddouk","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"2025021009050035400_r52","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.3748\/wjg.v23.i33.6111","article-title":"Ca2+\/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1\/2 and p38 pathways","volume":"23","author":"Chen","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"2025021009050035400_r53","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1158\/0008-5472.CAN-17-2392","article-title":"Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II","volume":"78","author":"Yu","year":"2018","journal-title":"Cancer Res."},{"key":"2025021009050035400_r54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ki.1990.171","article-title":"Anti-GBM nephritis in the mouse: role of granulocytes in the heterologous phase","volume":"38","author":"Schrijver","year":"1990","journal-title":"Kidney Int."},{"key":"2025021009050035400_r55","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/ki.1993.116","article-title":"Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice","volume":"43","author":"Feith","year":"1993","journal-title":"Kidney Int."},{"key":"2025021009050035400_r56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ki.1994.246","article-title":"A role for P selectin in complement-independent neutrophil-mediated glomerular injury","volume":"46","author":"Tipping","year":"1994","journal-title":"Kidney Int."},{"key":"2025021009050035400_r57","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.4049\/jimmunol.1100878","article-title":"The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions","volume":"188","author":"Hepper","year":"2012","journal-title":"J. Immunol."},{"key":"2025021009050035400_r58","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.immuni.2012.02.020","article-title":"Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense","volume":"36","author":"Irving","year":"2012","journal-title":"Immunity"},{"key":"2025021009050035400_r59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuron.2013.12.024","article-title":"CaMKII: claiming center stage in postsynaptic function and organization","volume":"81","author":"Hell","year":"2014","journal-title":"Neuron"},{"key":"2025021009050035400_r60","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrn753","article-title":"The molecular basis of CaMKII function in synaptic and behavioural memory","volume":"3","author":"Lisman","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"2025021009050035400_r61","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1073\/pnas.0701656104","article-title":"The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure","volume":"104","author":"Okamoto","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021009050035400_r62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(00)80681-9","article-title":"A role for CaMKII in T cell memory","volume":"100","author":"Bui","year":"2000","journal-title":"Cell"},{"key":"2025021009050035400_r63","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1182\/blood-2008-03-144022","article-title":"CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages","volume":"112","author":"Liu","year":"2008","journal-title":"Blood"},{"key":"2025021009050035400_r64","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajhg.2017.10.003","article-title":"De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability","volume":"101","author":"K\u00fcry","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"2025021009050035400_r65","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1038\/srep33132","article-title":"Phosphorylation of calcium\/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells","volume":"6","author":"Chi","year":"2016","journal-title":"Sci. Rep."},{"key":"2025021009050035400_r66","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1021\/bi00020a020","article-title":"Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro","volume":"34","author":"Ohta","year":"1995","journal-title":"Biochemistry"},{"key":"2025021009050035400_r67","doi-asserted-by":"crossref","first-page":"L983","DOI":"10.1152\/ajplung.2001.280.5.L983","article-title":"Regulation of endothelial cell barrier function by calcium\/calmodulin-dependent protein kinase II","volume":"280","author":"Borbiev","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021009050035400_r68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1471-4159.2004.02491.x","article-title":"Spinophilin is phosphorylated by Ca2+\/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin","volume":"90","author":"Grossman","year":"2004","journal-title":"J. Neurochem."},{"key":"2025021009050035400_r69","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/MAJ.0b013e318244745b","article-title":"Regulation of cofilin activity by CaMKII and calcineurin","volume":"344","author":"Zhao","year":"2012","journal-title":"Am. J. Med. Sci."},{"key":"2025021009050035400_r70","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.4049\/jimmunol.159.7.3595","article-title":"Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha","volume":"159","author":"Tessier","year":"1997","journal-title":"J. Immunol."},{"key":"2025021009050035400_r71","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.4049\/jimmunol.143.10.3309","article-title":"Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha","volume":"143","author":"Furie","year":"1989","journal-title":"J. Immunol."},{"key":"2025021009050035400_r72","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.4049\/jimmunol.152.8.4087","article-title":"Pulmonary epithelial cells facilitate TNF-alpha-induced neutrophil chemotaxis. A role for cytokine networking","volume":"152","author":"Smart","year":"1994","journal-title":"J. Immunol."},{"key":"2025021009050035400_r73","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2008.04.013","article-title":"Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases","volume":"28","author":"Tsuboi","year":"2008","journal-title":"Immunity"},{"key":"2025021009050035400_r74","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1074\/jbc.273.17.10556","article-title":"Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils","volume":"273","author":"Jones","year":"1998","journal-title":"J. Biol. Chem."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/9\/2173\/61465783\/ji2001349.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/9\/2173\/61465783\/ji2001349.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T09:05:26Z","timestamp":1739178326000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/208\/9\/2173\/7927246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,1]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2001349","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5]]},"published":{"date-parts":[[2022,5,1]]}}}