{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:50Z","timestamp":1790713430481,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Center for Craniofacial Regeneration"},{"name":"National Institute of Health","award":["DE022550"],"award-info":[{"award-number":["DE022550"]}]},{"name":"National Council for the Improvement of Higher Education"},{"DOI":"10.13039\/100007787","name":"National Research Center of Egypt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontal disease (PD) is a chronic destructive inflammatory disease of the tooth-supporting structures that leads to tooth loss at its advanced stages. Although the disease is initiated by a complex organization of oral microorganisms in the form of a plaque biofilm, it is the uncontrolled immune response to periodontal pathogens that fuels periodontal tissue destruction. IL-17A has been identified as a key cytokine in the pathogenesis of PD. Despite its well documented role in host defense against invading pathogens at oral barrier sites, IL-17A\u2013mediated signaling can also lead to a detrimental inflammatory response, causing periodontal bone destruction. In this study, we developed a local sustained delivery system that restrains IL-17A hyperactivity in periodontal tissues by incorporating neutralizing anti\u2013IL-17A Abs in poly(lactic-coglycolic) acid microparticles (MP). This formulation allowed for controlled release of anti\u2013IL-17A in the periodontium of mice with ligature-induced PD. Local delivery of anti\u2013IL-17A MP after murine PD induction inhibited alveolar bone loss and osteoclastic activity. The anti\u2013IL-17A MP formulation also decreased expression of IL-6, an IL-17A target gene known to induce bone resorption in periodontal tissues. This study demonstrates proof of concept that local and sustained release of IL-17A Abs constitutes a promising therapeutic strategy for PD and may be applicable to other osteolytic bone diseases mediated by IL-17A\u2013driven inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.2001432","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T13:16:17Z","timestamp":1620220577000},"page":"2386-2392","source":"Crossref","is-referenced-by-count":33,"title":["Local Sustained Delivery of Anti\u2013IL-17A Antibodies Limits Inflammatory Bone Loss in Murine Experimental Periodontitis"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7910-8975","authenticated-orcid":false,"given":"Cinthia M F","family":"Pacheco","sequence":"first","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-7043","authenticated-orcid":false,"given":"Katia L M","family":"Maltos","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa S","family":"Shehabeldin","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"},{"name":"Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh , Pittsburgh, PA"},{"name":"Department of Oral Biology, School of Dental Medicine, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-5081","authenticated-orcid":false,"given":"Laura L","family":"Thomas","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-1166","authenticated-orcid":false,"given":"Zhe","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"},{"name":"School of Medicine, Tsinghua University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"},{"name":"Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Verdelis","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-2041","authenticated-orcid":false,"given":"Sarah L","family":"Gaffen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo P","family":"Garlet","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Baru School of Dentistry, University of S\u00e3o Paulo , Bauru ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Chemical and Petroleum Engineering, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-3292","authenticated-orcid":false,"given":"Charles","family":"Sfeir","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Regeneration, University of Pittsburgh , Pittsburgh, PA"},{"name":"Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh , Pittsburgh, PA"},{"name":"Department of Oral Biology, School of Dental Medicine, University of Pittsburgh , Pittsburgh, PA"},{"name":"McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"2025030417503197200_r1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host 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Periodontol."},{"key":"2025030417503197200_r3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-051X.2010.01682.x","article-title":"Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions--consensus of the Seventh European Workshop on Periodontology","volume":"38","author":"Kinane","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"2025030417503197200_r4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0022034510385236","article-title":"Inflammation and uncoupling as mechanisms of periodontal bone loss","volume":"90","author":"Graves","year":"2011","journal-title":"J. Dent. Res."},{"key":"2025030417503197200_r5","doi-asserted-by":"crossref","first-page":"eaat0797","DOI":"10.1126\/scitranslmed.aat0797","article-title":"A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans","volume":"10","author":"Dutzan","year":"2018","journal-title":"Sci. Transl. 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