{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:09:12Z","timestamp":1791922152236,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002384"],"award-info":[{"award-number":["UL1 TR002384"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR064907"],"award-info":[{"award-number":["AR064907"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Calcitonin gene\u2013related peptide (CGRP) can bias the outcome of Ag presentation to responsive T cells in vitro away from Th1-type immunity and toward the Th2 and Th17 poles through actions on endothelial cells (ECs). To test the in vivo significance of this observation, we engineered a mouse lacking functional CGRP receptors on ECs (EC receptor activity modifying protein 1 [RAMP1] knockout mice). On percutaneous immunization to 1-fluoro-2,4-dinitrobenzene, stimulated CD4+ T cells from draining lymph nodes showed significantly reduced IL-17A expression with significantly increased IFN-\u03b3, IL-4, and IL-22 expression at the protein and mRNA levels compared with control mice. Retinoic acid receptor-related orphan receptor \u03b3 t mRNA was significantly reduced, while mRNAs for T-box expressed in T cells and GATA binding protein 3 were significantly increased. In addition, EC RAMP1 knockout mice had significantly reduced contact hypersensitivity responses, and systemic administration of a CGRP receptor antagonist similarly inhibited contact hypersensitivity in wild-type mice. These observations provide compelling evidence that CGRP is a key regulator of cutaneous immunity through effects on ECs and suggest a novel pathway for potential therapeutic manipulation.<\/jats:p>","DOI":"10.4049\/jimmunol.2100139","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T15:00:54Z","timestamp":1642172454000},"page":"633-641","source":"Crossref","is-referenced-by-count":19,"title":["Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene\u2013Related Peptide Signaling through Endothelial Cells"],"prefix":"10.1093","volume":"208","author":[{"given":"Wanhong","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L","family":"Stohl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jad","family":"Saab","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Azizi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-439X","authenticated-orcid":false,"given":"Xi K","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devina","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2824-7411","authenticated-orcid":false,"given":"Richard D","family":"Granstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"2025021008523593900_r1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj2550377","article-title":"Peptides from the calcitonin genes: molecular genetics, structure and function","volume":"255","author":"Breimer","year":"1988","journal-title":"Biochem. 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