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They interact with a variety of microenvironments, yet how NK cells engage with these varied microenvironments is not well documented. The adhesome represents a molecular network of defined and predicted integrin-mediated signaling interactions. In this study, we define the integrin adhesome expression profile of NK cells from human tonsil, peripheral blood, and those derived from human hematopoietic precursors through stromal cell coculture systems. We report that the site of cell isolation and NK cell developmental stage dictate differences in expression of adhesome associated genes and proteins. Furthermore, we define differences in cortical actin content associated with differential expression of actin regulating proteins, suggesting that differences in adhesome expression are associated with differences in cortical actin homeostasis. These data provide understanding of the diversity of human NK cell populations and how they engage with their microenvironment.<\/jats:p>","DOI":"10.4049\/jimmunol.2100162","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T16:05:19Z","timestamp":1626710719000},"page":"950-965","source":"Crossref","is-referenced-by-count":25,"title":["Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage"],"prefix":"10.1093","volume":"207","author":[{"given":"Everardo","family":"Hegewisch-Solloa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-6440","authenticated-orcid":false,"given":"Seungmae","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany L","family":"Mundy-Bosse","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, The Ohio State University , Columbus, OH"},{"name":"Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-5424","authenticated-orcid":false,"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University , Columbus, OH"},{"name":"Division of Dermatology, Department of Internal Medicine, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik H","family":"Waldman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Columbia University Medical Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-5109","authenticated-orcid":false,"given":"Sarah","family":"Maurrasse","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Columbia University Medical Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Grunstein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Columbia University Medical Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-7733","authenticated-orcid":false,"given":"Thomas J","family":"Connors","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-1521","authenticated-orcid":false,"given":"Aharon G","family":"Freud","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University , Columbus, OH"},{"name":"Department of Pathology, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-7393","authenticated-orcid":false,"given":"Emily M","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"key":"2025030501504589400_r1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/imr.12725","article-title":"Emerging insights into human health and NK cell biology from the study of NK cell deficiencies","volume":"287","author":"Mace","year":"2019","journal-title":"Immunol. 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