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CD8 TRM have been mainly studied in the skin, lung and gut, with recent studies suggesting that the signals that control tissue residence and phenotype are highly tissue dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B+ and TCF-1\u2013. To address if this phenotype is driven by CVT tissue residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 TRM in the mouse CVT gradually acquired a granzyme B+, TCF-1\u2013 phenotype as seen in human CVT. In contrast to CD8 TRM in the gut, these CD8 TRM were not stably maintained regardless of the initial infection route, which led to reductions in local immunity. Our data show that residence in the CVT is sufficient to progressively shape the size and function of its CD8 TRM compartment.<\/jats:p>","DOI":"10.4049\/jimmunol.2100166","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T14:25:36Z","timestamp":1622816736000},"page":"2937-2948","source":"Crossref","is-referenced-by-count":16,"title":["Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-192X","authenticated-orcid":false,"given":"Veronica A","family":"Dav\u00e9","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, WA"},{"name":"Graduate Program in Pathobiology, Department of Global Health, University of Washington , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E 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T","family":"Schiffer","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, WA"},{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA"},{"name":"Department of Medicine, University of Washington , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3284-979X","authenticated-orcid":false,"given":"Jennifer M","family":"Lund","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, WA"},{"name":"Graduate Program in Pathobiology, Department of Global Health, University of Washington , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-9321","authenticated-orcid":false,"given":"Martin","family":"Prlic","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious 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Immunol."},{"key":"2025030417503832800_r70","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature08757","article-title":"Targeting early infection to prevent HIV-1 mucosal transmission","volume":"464","author":"Haase","year":"2010","journal-title":"Nature"},{"key":"2025030417503832800_r71","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.4049\/jimmunol.160.12.6093","article-title":"T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2","volume":"160","author":"Milligan","year":"1998","journal-title":"J. Immunol."},{"key":"2025030417503832800_r72","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/viro.1998.9047","article-title":"Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge","volume":"243","author":"Morrison","year":"1998","journal-title":"Virology"},{"key":"2025030417503832800_r73","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1006\/viro.2000.0298","article-title":"Immune protection against HSV-2 in B-cell-deficient mice","volume":"270","author":"Dudley","year":"2000","journal-title":"Virology"},{"key":"2025030417503832800_r74","doi-asserted-by":"crossref","first-page":"e88529","DOI":"10.1172\/jci.insight.88529","article-title":"HSV-2 \u0394gD elicits Fc\u03b3R-effector antibodies that protect against clinical isolates","volume":"1","author":"Petro","year":"2016","journal-title":"JCI Insight"},{"key":"2025030417503832800_r75","doi-asserted-by":"crossref","first-page":"10587","DOI":"10.1128\/JVI.01237-12","article-title":"An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection","volume":"86","author":"Peng","year":"2012","journal-title":"J. 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