{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:16:30Z","timestamp":1790626590725,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0508502"],"award-info":[{"award-number":["2019YFA0508502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31930039"],"award-info":[{"award-number":["31930039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630058"],"award-info":[{"award-number":["81630058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91942303"],"award-info":[{"award-number":["91942303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31821003"],"award-info":[{"award-number":["31821003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971469"],"award-info":[{"award-number":["81971469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670904"],"award-info":[{"award-number":["31670904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The linear ubiquitin chain assembly complex (LUBAC) plays pivotal roles in regulating lymphocyte activation, inflammation, and cell death. This is highlighted by the fact that patients with mutations in LUBAC catalytic subunit HOIP suffer from autoinflammation combined with immunodeficiency. Although defective development of T and B cells resulting from HOIP deficiency in adaptive immunity can explain immunodeficiency, the pathogenesis of autoinflammation is not clear. In this study, we found that dendritic cell (DC)\u2013specific deletion of HOIP resulted in spontaneous inflammation, indicating the essential role of HOIP in maintaining DC homeostasis. Although HOIP deficiency in DCs did not affect TNF-\u03b1\u2013induced NF-\u03baB activation, it enhanced TNF-\u03b1\u2013induced apoptosis and necroptosis. However, crossing HoipDC KO mice with TNFR1-knockout mice surprisingly could not rescue the systematic inflammation, suggesting that the autoinflammation is not due to the effect of HOIP on TNF-\u03b1 signaling. In contrast, treatment of HoipDC KO mice with antibiotics reduced the inflammation, implying that TLR signaling may contribute to the inflammatory phenotype found in HoipDC KO mice. Consistently, we found that LPS induced more cell death and significantly higher levels of IL-1\u03b1 and IL-1\u03b2 in HoipDC KO cells. Importantly, MyD88 deficiency rescued the inflammatory phenotype in HoipDC KO mice. Together, these findings reveal the indispensable function of HOIP in maintaining DC homeostasis, and MyD88-dependent proinflammatory signal plays a substantial role in the pathogenesis of human autoinflammation associated with HOIP mutations.<\/jats:p>","DOI":"10.4049\/jimmunol.2100173","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T15:35:15Z","timestamp":1626104115000},"page":"542-554","source":"Crossref","is-referenced-by-count":8,"title":["MyD88-Dependent Signaling Is Required for HOIP Deficiency\u2013Induced Autoinflammation"],"prefix":"10.1093","volume":"207","author":[{"given":"Xin","family":"Wu","sequence":"first","affiliation":[{"name":"Institute for Immunology, Tsinghua University School of Medicine , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Tsinghua University School of Medicine , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Tsinghua University School of Medicine , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-5583","authenticated-orcid":false,"given":"Xueqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Tsinghua University School of Medicine , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-3654","authenticated-orcid":false,"given":"Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Tsinghua University School of Medicine , Beijing ,","place":["China"]},{"name":"Tsinghua-Peking Center for Life Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"2025022608110461300_r1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature09816","article-title":"Linear ubiquitination prevents inflammation and regulates immune signalling","volume":"471","author":"Gerlach","year":"2011","journal-title":"Nature"},{"key":"2025022608110461300_r2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature09814","article-title":"SHARPIN forms a linear ubiquitin ligase complex regulating NF-\u03baB activity and apoptosis","volume":"471","author":"Ikeda","year":"2011","journal-title":"Nature"},{"key":"2025022608110461300_r3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature09815","article-title":"SHARPIN is a component of the NF-\u03baB-activating linear ubiquitin chain assembly complex","volume":"471","author":"Tokunaga","year":"2011","journal-title":"Nature"},{"key":"2025022608110461300_r4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imr.12309","article-title":"Linear ubiquitination in immunity","volume":"266","author":"Shimizu","year":"2015","journal-title":"Immunol. Rev."},{"key":"2025022608110461300_r5","doi-asserted-by":"crossref","first-page":"jcs208512","DOI":"10.1242\/jcs.208512","article-title":"Linear ubiquitination at a glance","volume":"132","author":"Spit","year":"2019","journal-title":"J. Cell Sci."},{"key":"2025022608110461300_r6","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1084\/jem.20160041","article-title":"--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation","volume":"213","author":"Zinngrebe","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025022608110461300_r7","doi-asserted-by":"crossref","first-page":"13353","DOI":"10.1038\/ncomms13353","article-title":"Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis","volume":"7","author":"Teh","year":"2016","journal-title":"Nat. Commun."},{"key":"2025022608110461300_r8","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.4049\/jimmunol.1701526","article-title":"Crucial role of linear ubiquitin chain assembly complex-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development","volume":"200","author":"Sasaki","year":"2018","journal-title":"J. Immunol."},{"key":"2025022608110461300_r9","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.15252\/embj.201695699","article-title":"The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death","volume":"36","author":"Lafont","year":"2017","journal-title":"EMBO J."},{"key":"2025022608110461300_r10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.celrep.2014.08.066","article-title":"HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death","volume":"9","author":"Peltzer","year":"2014","journal-title":"Cell Rep."},{"key":"2025022608110461300_r11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-018-0064-8","article-title":"LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis","volume":"557","author":"Peltzer","year":"2018","journal-title":"Nature"},{"key":"2025022608110461300_r12","first-page":"972","article-title":"A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice","volume":"143","author":"HogenEsch","year":"1993","journal-title":"Am. J. Pathol."},{"key":"2025022608110461300_r13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.gene.6364403","article-title":"Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis","volume":"8","author":"Seymour","year":"2007","journal-title":"Genes Immun."},{"key":"2025022608110461300_r14","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.20141130","article-title":"Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia","volume":"212","author":"Boisson","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025022608110461300_r15","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.2457","article-title":"Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency","volume":"13","author":"Boisson","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025022608110461300_r16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fimmu.2019.00479","article-title":"Second case of HOIP deficiency expands clinical features and defines inflammatory transcriptome regulated by LUBAC","volume":"10","author":"Oda","year":"2019","journal-title":"Front. Immunol."},{"key":"2025022608110461300_r17","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/emboj.2013.184","article-title":"Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells","volume":"32","author":"Sasaki","year":"2013","journal-title":"EMBO J."},{"key":"2025022608110461300_r18","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1122545","article-title":"Dendritic cell apoptosis in the maintenance of immune tolerance","volume":"311","author":"Chen","year":"2006","journal-title":"Science"},{"key":"2025022608110461300_r19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(01)00455-X","article-title":"Regulation of T cell immunity by dendritic cells","volume":"106","author":"Lanzavecchia","year":"2001","journal-title":"Cell"},{"key":"2025022608110461300_r20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nri3149","article-title":"Transcriptional programming of the dendritic cell network. [Published erratum appears in 2013 Nat. Rev. Immunol. 13: 149.]","volume":"12","author":"Belz","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025022608110461300_r21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.1000325","article-title":"Dendritic cell apoptosis: regulation of tolerance versus immunity","volume":"185","author":"Kushwah","year":"2010","journal-title":"J. Immunol."},{"key":"2025022608110461300_r22","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.celrep.2013.04.033","article-title":"Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells","volume":"3","author":"Young","year":"2013","journal-title":"Cell Rep."},{"key":"2025022608110461300_r23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.immuni.2007.03.016","article-title":"Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity","volume":"26","author":"Stranges","year":"2007","journal-title":"Immunity"},{"key":"2025022608110461300_r24","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.4049\/jimmunol.1400122","article-title":"Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation","volume":"192","author":"Cuda","year":"2014","journal-title":"J. Immunol."},{"key":"2025022608110461300_r25","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.4049\/jimmunol.1800172","article-title":"RNF31 regulates skin homeostasis by protecting epidermal keratinocytes from cell death","volume":"200","author":"Tang","year":"2018","journal-title":"J. Immunol."},{"key":"2025022608110461300_r26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature10273","article-title":"FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation","volume":"477","author":"Welz","year":"2011","journal-title":"Nature"},{"key":"2025022608110461300_r27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI9244","article-title":"CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus","volume":"106","author":"Mihara","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2025022608110461300_r28","doi-asserted-by":"crossref","first-page":"20054","DOI":"10.1073\/pnas.1116302108","article-title":"Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway","volume":"108","author":"He","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025022608110461300_r29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nri2335","article-title":"Dendritic cells in intestinal immune regulation","volume":"8","author":"Coombes","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025022608110461300_r30","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1098231","article-title":"A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death","volume":"305","author":"Li","year":"2004","journal-title":"Science"},{"key":"2025022608110461300_r31","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.4049\/jimmunol.179.3.1834","article-title":"The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death","volume":"179","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"2025022608110461300_r32","doi-asserted-by":"crossref","first-page":"e2422","DOI":"10.1038\/cddis.2016.311","article-title":"Loss of XIAP facilitates switch to TNF\u03b1-induced necroptosis in mouse neutrophils","volume":"7","author":"Wicki","year":"2016","journal-title":"Cell Death Dis."},{"key":"2025022608110461300_r33","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1128\/IAI.72.4.1856-1865.2004","article-title":"Mechanisms involved in apoptosis of human macrophages induced by lipopolysaccharide from Actinobacillus actinomycetemcomitans in the presence of cycloheximide","volume":"72","author":"Suzuki","year":"2004","journal-title":"Infect. Immun."},{"key":"2025022608110461300_r34","doi-asserted-by":"crossref","first-page":"e716","DOI":"10.1038\/cddis.2013.238","article-title":"Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia","volume":"4","author":"Kim","year":"2013","journal-title":"Cell Death Dis."},{"key":"2025022608110461300_r35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.celrep.2012.03.010","article-title":"Survival function of the FADD-CASPASE-8-cFLIP(L) complex","volume":"1","author":"Dillon","year":"2012","journal-title":"Cell Rep."},{"key":"2025022608110461300_r36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature09852","article-title":"Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis","volume":"471","author":"Oberst","year":"2011","journal-title":"Nature"},{"key":"2025022608110461300_r37","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09857","article-title":"RIP3 mediates the embryonic lethality of caspase-8-deficient mice","volume":"471","author":"Kaiser","year":"2011","journal-title":"Nature"},{"key":"2025022608110461300_r38","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/cdd.2016.46","article-title":"RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury","volume":"23","author":"Newton","year":"2016","journal-title":"Cell Death Differ."},{"key":"2025022608110461300_r39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.immuni.2016.07.016","article-title":"The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death-receptor-induced apoptosis","volume":"45","author":"Alvarez-Diaz","year":"2016","journal-title":"Immunity"},{"key":"2025022608110461300_r40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","author":"Kono","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025022608110461300_r41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"2025022608110461300_r42","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"2025022608110461300_r43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"2025022608110461300_r44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-9255-8-22","article-title":"Role of IL-33 in inflammation and disease","volume":"8","author":"Miller","year":"2011","journal-title":"J. Inflamm. (Lond.)"},{"key":"2025022608110461300_r45","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/hep.29074","article-title":"The LINEAR ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis","volume":"65","author":"Shimizu","year":"2017","journal-title":"Hepatology"},{"key":"2025022608110461300_r46","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1038\/s41467-018-06155-8","article-title":"LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L","volume":"9","author":"Taraborrelli","year":"2018","journal-title":"Nat. Commun."},{"key":"2025022608110461300_r47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrm.2016.149","article-title":"Necroptosis in development, inflammation and disease","volume":"18","author":"Weinlich","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025022608110461300_r48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: the expanding network of non-apoptotic cell death pathways","volume":"15","author":"Vanden Berghe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025022608110461300_r49","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1074\/jbc.RA119.011622","article-title":"Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation","volume":"295","author":"Douglas","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2025022608110461300_r50","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ajpath.2015.12.026","article-title":"An essential role for SHARPIN in the regulation of caspase 1 activity in sepsis","volume":"186","author":"Nastase","year":"2016","journal-title":"Am. J. Pathol."},{"key":"2025022608110461300_r51","doi-asserted-by":"crossref","first-page":"e03464","DOI":"10.7554\/eLife.03464","article-title":"TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice","volume":"3","author":"Rickard","year":"2014","journal-title":"eLife"},{"key":"2025022608110461300_r52","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.4049\/jimmunol.1500542","article-title":"The inflammatory caspases-1 and -11 mediate the pathogenesis of dermatitis in sharpin-deficient mice","volume":"195","author":"Douglas","year":"2015","journal-title":"J. Immunol."},{"key":"2025022608110461300_r53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.4049\/jimmunol.1701229","article-title":"Dendritic cell RIPK1 maintains immune homeostasis by preventing inflammation and autoimmunity","volume":"200","author":"O\u2019Donnell","year":"2018","journal-title":"J. Immunol."},{"key":"2025022608110461300_r54","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41418-018-0159-7","article-title":"Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice","volume":"26","author":"Sharma","year":"2019","journal-title":"Cell Death Differ."},{"key":"2025022608110461300_r55","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-immunol-030409-101311","article-title":"The sterile inflammatory response","volume":"28","author":"Rock","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"2025022608110461300_r56","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(00)04954-0","article-title":"Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial","volume":"357","author":"Chaudhari","year":"2001","journal-title":"Lancet"},{"key":"2025022608110461300_r57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm.3897","article-title":"Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies","volume":"21","author":"Cho","year":"2015","journal-title":"Nat. Med."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/207\/2\/542\/61876605\/ji2100173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/207\/2\/542\/61876605\/ji2100173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T08:11:45Z","timestamp":1740557505000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/207\/2\/542\/7944435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,7,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2100173","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7]]},"published":{"date-parts":[[2021,7]]}}}