{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:26:08Z","timestamp":1771237568398,"version":"3.50.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"the Program Management Unit for Human Resources and Institutional Development, Research and Innovation, NXPO","award":["B05F630043"],"award-info":[{"award-number":["B05F630043"]}]},{"name":"the Royal Golden Jubilee Ph.D (RGJ-PHD) Program Scholarship","award":["PHD\/0016\/2558"],"award-info":[{"award-number":["PHD\/0016\/2558"]}]},{"name":"the Thammasat University Research Unit in Molecular Pathogenesis and Immunology of Infectious diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A multifunctional glycoprotein, osteopontin (OPN), can modulate the function of macrophages, resulting in either protective or deleterious effects in various inflammatory diseases and infection in the lungs. Although macrophages play the critical roles in mediating host defenses against cryptococcosis or cryptococcal pathogenesis, the involvement of macrophage-derived OPN in pulmonary infection caused by fungus Cryptococcus has not been elucidated. Thus, our current study aimed to investigate the contribution of OPN to the regulation of host immune response and macrophage function using a mouse model of pulmonary cryptococcosis. We found that OPN was predominantly expressed in alveolar macrophages during C. neoformans infection. Systemic treatment of OPN during C. neoformans infection resulted in an enhanced pulmonary fungal load and an early onset of type 2 inflammation within the lung, as indicated by the increase of pulmonary eosinophil infiltration, type 2 cytokine production, and M2-associated gene expression. Moreover, CRISPR\/Cas9\u2013mediated OPN knockout murine macrophages had enhanced ability to clear the intracellular fungus and altered macrophage phenotype from pathogenic M2 to protective M1. Altogether, our data suggested that macrophage-derived OPN contributes to the elaboration of C. neoformans\u2013induced type 2 immune responses and polarization of M2s that promote fungal survival and proliferation within macrophages.<\/jats:p>","DOI":"10.4049\/jimmunol.2100202","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T18:45:23Z","timestamp":1631731523000},"page":"2107-2117","source":"Crossref","is-referenced-by-count":20,"title":["Macrophage-Derived Osteopontin Influences the Amplification of <i>Cryptococcus neoformans<\/i>\u2013Promoting Type 2 Immune Response"],"prefix":"10.1093","volume":"207","author":[{"given":"Adithap","family":"Hansakon","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University , Pathumthani ,","place":["Thailand"]},{"name":"Graduate Program in Biomedical Science, Faculty of Allied Health Sciences, Thammasat University , Pathumthani ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-0316","authenticated-orcid":false,"given":"Chin Wen","family":"Png","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Yong Loo Lin School of Medicine , Singapore ,","place":["Singapore"]},{"name":"Immunology Programme, Life Science Institute, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Yong Loo Lin School of Medicine , Singapore ,","place":["Singapore"]},{"name":"Immunology Programme, Life Science Institute, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-9544","authenticated-orcid":false,"given":"Pornpimon","family":"Angkasekwinai","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University , Pathumthani ,","place":["Thailand"]},{"name":"Research Unit in Molecular Pathogenesis and Immunology of Infectious Diseases, Thammasat University , Pathumthani ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"2025022610321929800_r1","doi-asserted-by":"crossref","first-page":"7675437","DOI":"10.1155\/2016\/7675437","article-title":"Osteopontin bridging innate and adaptive immunity in autoimmune diseases","volume":"2016","author":"Clemente","year":"2016","journal-title":"J. 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