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The transcription factor CREM\u03b1 controls effector T cell function in people with systemic autoimmune diseases. The inhibitory surface coreceptor PD-1 plays a key role in the control of effector T cell function and its therapeutic inhibition in patients with cancer can cause psoriasis. In this study, we show that CD4+ T cells from patients with psoriasis and psoriatic arthritis exhibit increased production of IL-17 but decreased expression of IL-2 and PD-1. In genetically modified mice and Jurkat T cells CREM\u03b1 expression was linked to low PD-1 levels. We demonstrate that CREM\u03b1 is recruited to the proximal promoter of PDCD1 in which it trans-represses gene expression and corecruits DNMT3a-mediating DNA methylation. As keratinocytes limit inflammation by PD-1 ligand expression and, in this study, reported reduced expression of PD-1 on CD4+ T cells is linked to low IL-2 and high IL-17A production, our studies reveal a molecular pathway in T cells from people with psoriasis that can deserve clinical exploitation.<\/jats:p>","DOI":"10.4049\/jimmunol.2100240","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T18:10:37Z","timestamp":1623867037000},"page":"55-64","source":"Crossref","is-referenced-by-count":10,"title":["Cyclic AMP Response Element Modulator-\u03b1 Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-1143","authenticated-orcid":false,"given":"Sigrun R","family":"Hofmann","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Carl Gustav Carus, Technische Universit\u00e4t Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Kapplusch","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Carl Gustav Carus, Technische Universit\u00e4t Dresden , Dresden 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-6481","authenticated-orcid":false,"given":"Susanne","family":"Abraham","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Universit\u00e4tsklinikum Carl Gustav Carus, Technische Universit\u00e4t Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-7175","authenticated-orcid":false,"given":"Sarah","family":"Northey","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Russ","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Carl Gustav Carus, Technische Universit\u00e4t Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-3005","authenticated-orcid":false,"given":"Anna E A","family":"Surace","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuya","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Department of 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