{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:28:47Z","timestamp":1762432127903,"version":"3.38.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM112945"],"award-info":[{"award-number":["R01GM112945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI125366"],"award-info":[{"award-number":["R01AI125366"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI12829"],"award-info":[{"award-number":["R01AI12829"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>REDD1 is an energy sensor and stress-induced mTOR inhibitor. Recently, its novel role in linking metabolism and inflammation\/immune responses has emerged. In this study, we assessed the role of REDD1 in murine oxazolone-induced allergic contact dermatitis (ACD), a T cell\u2013dependent model with features of human ACD. A variety of immune indices, including edema, cellular infiltration, inflammatory gene expression, and glucocorticoid response, were compared in Redd1 knockout (KO) and isogenic (C57BL\/6 \u00d7 129)F1 wild-type mice after sensitization and subsequent ear challenge with oxazolone. Despite relatively normal thymic profiles and similar T cell populations in the lymph nodes of naive Redd1 KO mice, early T cell expansion and cytokine production were profoundly impaired after sensitization. Surprisingly, higher steady-state populations of CD4+ and CD8+ T cells, as well as macrophages (CD45+\/Ly-6G\u2212\/CD11b+), dendritic cells (CD45+\/Ly-6G\u2212\/CD11c+), neutrophils (CD45+\/Ly-6G+\/CD11b+), and innate lymphoid cells (CD45+\/Lineage\u2212\/IL-7Ra+\/ST2+\/c-Kit+), were observed in the ears of naive Redd1 KO mice. Upon challenge, ear edema, T cell, macrophage, neutrophil, and dendritic cell infiltration into the ear was significantly reduced in Redd1 KO animals. Accordingly, we observed significantly lower induction of IFN-\u03b3, IL-4, and other cytokines as well as proinflammatory factors, including TSLP, IL-33, IL-1\u03b2, IL-6, and TNF-\u03b1, in challenged ears of Redd1 KO mice. The response to glucocorticoid treatment was also diminished. Taken together, these data establish REDD1 as an essential immune modulator that influences both the initiation of ACD disease, by driving naive T cell activation, and the effector phase, by promoting immune cell trafficking in T cell\u2013mediated skin inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.2100279","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T15:30:19Z","timestamp":1630078219000},"page":"1747-1754","source":"Crossref","is-referenced-by-count":5,"title":["Early Stress-Response Gene REDD1 Controls Oxazolone-Induced Allergic Contact Dermatitis"],"prefix":"10.1093","volume":"207","author":[{"given":"Salida","family":"Mirzoeva","sequence":"first","affiliation":[{"name":"Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-5122","authenticated-orcid":false,"given":"Yuchen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-3414","authenticated-orcid":false,"given":"Anna","family":"Klopot","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-6822","authenticated-orcid":false,"given":"Irina","family":"Budunova","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"2025022610321436000_r1","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.4161\/cc.4.11.2139","article-title":"Growth control under stress: mTOR regulation through the REDD1-TSC pathway","volume":"4","author":"Ellisen","year":"2005","journal-title":"Cell Cycle"},{"key":"2025022610321436000_r2","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1256804","article-title":"Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1\/TSC2 tumor suppressor complex","volume":"18","author":"Brugarolas","year":"2004","journal-title":"Genes Dev."},{"key":"2025022610321436000_r3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1101\/gad.1617608","article-title":"Hypoxia regulates TSC1\/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling","volume":"22","author":"DeYoung","year":"2008","journal-title":"Genes Dev."},{"key":"2025022610321436000_r4","doi-asserted-by":"crossref","first-page":"ra68","DOI":"10.1126\/scisignal.2005103","article-title":"REDD1 enhances protein phosphatase 2A-mediated dephosporylation of Akt to repress mTORC1 signaling","volume":"7","author":"Dennis","year":"2014","journal-title":"Sci. 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