{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:28:00Z","timestamp":1787740080198,"version":"build-2784847793"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870887"],"award-info":[{"award-number":["31870887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670909"],"award-info":[{"award-number":["31670909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB29030301"],"award-info":[{"award-number":["XDB29030301"]}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDPB16"],"award-info":[{"award-number":["XDPB16"]}]},{"name":"Shanghai Municipal Science and Technology Major Project","award":["2019SHZDZX02"],"award-info":[{"award-number":["2019SHZDZX02"]}]},{"name":"CAS Youth Innovation Promotion Association","award":["2012083"],"award-info":[{"award-number":["2012083"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipid droplets (LDs), the highly dynamic intracellular organelles, are critical for lipid metabolism. Dynamic alterations in the configurations and functions of LDs during innate immune responses to bacterial infections and the underlying mechanisms, however, remain largely unknown. In this study, we trace the time-course morphology of LDs in fat bodies of Drosophila after transient bacterial infection. Detailed analysis shows that perilipin1 (plin1), a core gene involved in the regulation of LDs, is suppressed by the immune deficiency signaling, one major innate immune pathway in Drosophila. During immune activation, downregulated plin1 promotes the enlargement of LDs, which in turn alleviates immune reaction\u2013associated reactive oxygen species stress. Thus, the growth of LDs is likely an active adaptation to maintain redox homeostasis in response to immune deficiency activation. Therefore, our study provides evidence that plin1 serves as a modulator on LDs\u2019 reconfiguration in regulating infection-induced pathogenesis, and plin1 might be a potential therapeutic target for coordinating inflammation resolution and lipid metabolism.<\/jats:p>","DOI":"10.4049\/jimmunol.2100343","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T16:23:36Z","timestamp":1632932616000},"page":"2347-2358","source":"Crossref","is-referenced-by-count":12,"title":["Downregulation of Perilipin1 by the Immune Deficiency Pathway Leads to Lipid Droplet Reconfiguration and Adaptation to Bacterial Infection in\n                    <i>Drosophila<\/i>"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-5182","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, Hubei ,","place":["China"]},{"name":"The Center for Microbes, Development, and Health, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-6904","authenticated-orcid":false,"given":"Jiaxin","family":"Lin","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development, and Health, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing ,","place":["China"]},{"name":"Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjing","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development, and Health, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing ,","place":["China"]},{"name":"Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development, and Health, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing ,","place":["China"]},{"name":"Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-7381","authenticated-orcid":false,"given":"Hong","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-8904","authenticated-orcid":false,"given":"Lei","family":"Pan","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development, and Health, Institut Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing ,","place":["China"]},{"name":"Chinese Academy of Sciences Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"2025022610322263800_r1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2017.08.009","article-title":"Foundations of immunometabolism and implications for metabolic health and disease","volume":"47","author":"Hotamisligil","year":"2017","journal-title":"Immunity."},{"key":"2025022610322263800_r2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"2025022610322263800_r3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/jb\/mvs092","article-title":"Mediator lipidomics in acute inflammation and resolution","volume":"152","author":"Arita","year":"2012","journal-title":"J. Biochem."},{"key":"2025022610322263800_r4","doi-asserted-by":"crossref","first-page":"a016311","DOI":"10.1101\/cshperspect.a016311","article-title":"Lipid mediators in the resolution of inflammation","volume":"7","author":"Serhan","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2025022610322263800_r5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/iub.1737","article-title":"The role of lipids in host-pathogen interactions","volume":"70","author":"Walpole","year":"2018","journal-title":"IUBMB Life."},{"key":"2025022610322263800_r6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0163-7827(01)00013-3","article-title":"The biogenesis and functions of lipid bodies in animals, plants and microorganisms","volume":"40","author":"Murphy","year":"2001","journal-title":"Prog. Lipid Res."},{"key":"2025022610322263800_r7","doi-asserted-by":"crossref","first-page":"44507","DOI":"10.1074\/jbc.M207712200","article-title":"The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition","volume":"277","author":"Tauchi-Sato","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025022610322263800_r8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev-biochem-061009-102430","article-title":"Lipid droplets and cellular lipid metabolism","volume":"81","author":"Walther","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"2025022610322263800_r9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025022610322263800_r10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.it.2018.01.012","article-title":"Lipid droplets as immune modulators in myeloid cells","volume":"39","author":"den Brok","year":"2018","journal-title":"Trends Immunol."},{"key":"2025022610322263800_r11","doi-asserted-by":"crossref","first-page":"20452","DOI":"10.1073\/pnas.0911679106","article-title":"The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix","volume":"106","author":"Hinson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025022610322263800_r12","doi-asserted-by":"crossref","first-page":"e00003","DOI":"10.7554\/eLife.00003","article-title":"A novel role for lipid droplets in the organismal antibacterial response","volume":"1","author":"Anand","year":"2012","journal-title":"eLife."},{"key":"2025022610322263800_r13","doi-asserted-by":"crossref","first-page":"eaay8085","DOI":"10.1126\/science.aay8085","article-title":"Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense","volume":"370","author":"Bosch","year":"2020","journal-title":"Science."},{"key":"2025022610322263800_r14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/JLB.4MR0119-035R","article-title":"Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation","volume":"106","author":"Pereira-Dutra","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"2025022610322263800_r15","doi-asserted-by":"crossref","first-page":"e98947","DOI":"10.15252\/embj.201898947","article-title":"The assembly of lipid droplets and their roles in challenged cells. [Published erratum appears in 2019 EMBO J. 38: E101816]","volume":"37","author":"Henne","year":"2018","journal-title":"EMBO J."},{"key":"2025022610322263800_r16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1021\/acsinfecdis.8b00301","article-title":"Quantitative lipid droplet proteomics reveals Mycobacterium tuberculosis induced alterations in macrophage response to infection","volume":"5","author":"Menon","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"2025022610322263800_r17","doi-asserted-by":"crossref","first-page":"bio039040","DOI":"10.1242\/bio.039040","article-title":"Intestinal lipid droplets as novel mediators of host-pathogen interaction in Drosophila","volume":"8","author":"Harsh","year":"2019","journal-title":"Biol. Open."},{"key":"2025022610322263800_r18","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1194\/jlr.R066514","article-title":"Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment","volume":"57","author":"Ertunc","year":"2016","journal-title":"J. Lipid Res."},{"key":"2025022610322263800_r19","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025022610322263800_r20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.20283","article-title":"Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway","volume":"40","author":"Feldstein","year":"2004","journal-title":"Hepatology."},{"key":"2025022610322263800_r21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.plipres.2005.11.002","article-title":"Ceramides in insulin resistance and lipotoxicity","volume":"45","author":"Summers","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"2025022610322263800_r22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature06928","article-title":"Functional genomic screen reveals genes involved in lipid-droplet formation and utilization","volume":"453","author":"Guo","year":"2008","journal-title":"Nature."},{"key":"2025022610322263800_r23","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1074\/mcp.M600011-MCP200","article-title":"Characterization of the Drosophila lipid droplet subproteome","volume":"5","author":"Beller","year":"2006","journal-title":"Mol. Cell. Proteomics."},{"key":"2025022610322263800_r24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12944-017-0473-y","article-title":"Perilipins: a diversity of intracellular lipid droplet proteins","volume":"16","author":"Itabe","year":"2017","journal-title":"Lipids Health Dis."},{"key":"2025022610322263800_r25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-nutr-071813-105410","article-title":"The perilipins: major cytosolic lipid droplet-associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis","volume":"36","author":"Kimmel","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"2025022610322263800_r26","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","article-title":"The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis","volume":"1862","author":"Sztalryd","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids."},{"key":"2025022610322263800_r27","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1242\/jcs.101329","article-title":"Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization","volume":"125","author":"Bi","year":"2012","journal-title":"J. Cell Sci."},{"key":"2025022610322263800_r28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cmet.2010.10.001","article-title":"PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila","volume":"12","author":"Beller","year":"2010","journal-title":"Cell Metab."},{"key":"2025022610322263800_r29","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","article-title":"Perilipin deficiency and autosomal dominant partial lipodystrophy","volume":"364","author":"Gandotra","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2025022610322263800_r30","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.101042998","article-title":"Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity","volume":"98","author":"Tansey","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025022610322263800_r31","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1038\/ncomms14859","article-title":"Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice. [Published erratum appears in 2017 Nat. Commun. 8: 15490]","volume":"8","author":"Schweiger","year":"2017","journal-title":"Nat. Commun."},{"key":"2025022610322263800_r32","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes."},{"key":"2025022610322263800_r33","doi-asserted-by":"crossref","first-page":"13974","DOI":"10.1074\/jbc.RA118.003541","article-title":"Perilipin 1 (Plin1) deficiency promotes inflammatory responses in lean adipose tissue through lipid dysregulation","volume":"293","author":"Sohn","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2025022610322263800_r34","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1534\/genetics.118.301583","article-title":"Triacylglycerol metabolism in Drosophila melanogaster","volume":"210","author":"Heier","year":"2018","journal-title":"Genetics."},{"key":"2025022610322263800_r35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"2025022610322263800_r36","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.4049\/jimmunol.1303309","article-title":"The Drosophila imd signaling pathway","volume":"192","author":"Myllym\u00e4ki","year":"2014","journal-title":"J. Immunol."},{"key":"2025022610322263800_r37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev-ento-112408-085356","article-title":"Insect fat body: energy, metabolism, and regulation","volume":"55","author":"Arrese","year":"2010","journal-title":"Annu. Rev. Entomol."},{"key":"2025022610322263800_r38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.dci.2013.05.014","article-title":"The Drosophila IMD pathway in the activation of the humoral immune response","volume":"42","author":"Kleino","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"2025022610322263800_r39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbalip.2009.04.002","article-title":"PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores","volume":"1791","author":"Bickel","year":"2009","journal-title":"Biochim. Biophys. Acta."},{"key":"2025022610322263800_r40","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/dvdy.20277","article-title":"Drosophila Lipid Storage Droplet 2 gene (Lsd-2) is expressed and controls lipid storage in wing imaginal discs","volume":"232","author":"Fauny","year":"2005","journal-title":"Dev. Dyn."},{"key":"2025022610322263800_r41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0960-9822(03)00175-1","article-title":"Control of fat storage by a Drosophila PAT domain protein","volume":"13","author":"Gr\u00f6nke","year":"2003","journal-title":"Curr. Biol."},{"key":"2025022610322263800_r42","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0925-4773(03)00158-8","article-title":"Drosophila Perilipin\/ADRP homologue Lsd2 regulates lipid metabolism","volume":"120","author":"Teixeira","year":"2003","journal-title":"Mech. Dev."},{"key":"2025022610322263800_r43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.devcel.2019.04.009","article-title":"NF-\u03baB shapes metabolic adaptation by attenuating Foxo-mediated lipolysis in Drosophila","volume":"49","author":"Molaei","year":"2019","journal-title":"Dev. Cell."},{"key":"2025022610322263800_r44","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cmet.2018.05.026","article-title":"The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism","volume":"28","author":"Kamareddine","year":"2018","journal-title":"Cell Metab."},{"key":"2025022610322263800_r45","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature734","article-title":"The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein","volume":"416","author":"Gottar","year":"2002","journal-title":"Nature."},{"key":"2025022610322263800_r46","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1474-9726.2008.00421.x","article-title":"Characterization of the Drosophila gene-switch system in aging studies: A cautionary tale","volume":"7","author":"Poirier","year":"2008","journal-title":"Aging Cell."},{"key":"2025022610322263800_r47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.devcel.2007.12.002","article-title":"Keap1\/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila","volume":"14","author":"Sykiotis","year":"2008","journal-title":"Dev. Cell."},{"key":"2025022610322263800_r48","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ni922","article-title":"The Drosophila immune system detects bacteria through specific peptidoglycan recognition","volume":"4","author":"Leulier","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025022610322263800_r49","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ni.3536","article-title":"The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors","volume":"17","author":"Neyen","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025022610322263800_r50","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1073\/pnas.0502240102","article-title":"Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species","volume":"102","author":"Vodovar","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025022610322263800_r51","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1194\/jlr.R024299","article-title":"Thematic review series: Lipid droplet synthesis and metabolism: From yeast to man. Lipid droplet-based storage fat metabolism in Drosophila","volume":"53","author":"K\u00fchnlein","year":"2012","journal-title":"J. Lipid Res."},{"key":"2025022610322263800_r52","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1016\/j.celrep.2018.08.026","article-title":"MRT, functioning with NURF complex, regulates lipid droplet size","volume":"24","author":"Yao","year":"2018","journal-title":"Cell Rep."},{"key":"2025022610322263800_r53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1074-7613(04)00104-9","article-title":"Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway","volume":"20","author":"Kaneko","year":"2004","journal-title":"Immunity."},{"key":"2025022610322263800_r54","doi-asserted-by":"crossref","first-page":"17056","DOI":"10.1038\/nmicrobiol.2017.56","article-title":"Bap180\/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice","volume":"2","author":"He","year":"2017","journal-title":"Nat. Microbiol."},{"key":"2025022610322263800_r55","doi-asserted-by":"crossref","first-page":"e418","DOI":"10.1371\/journal.pbio.0020418","article-title":"Secreted bacterial effectors and host-produced Eiger\/TNF drive death in aSalmonella-infected fruit fly","volume":"2","author":"Brandt","year":"2004","journal-title":"PLoS Biol."},{"key":"2025022610322263800_r56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2010","journal-title":"Cell Res."},{"key":"2025022610322263800_r57","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cub.2013.06.032","article-title":"Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity","volume":"23","author":"Herms","year":"2013","journal-title":"Curr. Biol."},{"key":"2025022610322263800_r58","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/genetics\/134.3.781","article-title":"Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster","volume":"134","author":"Griswold","year":"1993","journal-title":"Genetics."},{"key":"2025022610322263800_r59","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1073\/pnas.86.8.2761","article-title":"Null mutation of copper\/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity","volume":"86","author":"Phillips","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025022610322263800_r60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"2025022610322263800_r61","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1117311","article-title":"A direct role for dual oxidase in Drosophila gut immunity","volume":"310","author":"Ha","year":"2005","journal-title":"Science."},{"key":"2025022610322263800_r62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.devcel.2004.11.007","article-title":"An antioxidant system required for host protection against gut infection in Drosophila","volume":"8","author":"Ha","year":"2005","journal-title":"Dev. Cell."},{"key":"2025022610322263800_r63","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell."},{"key":"2025022610322263800_r64","doi-asserted-by":"crossref","first-page":"e1000204","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"Peyron","year":"2008","journal-title":"PLoS Pathog."},{"key":"2025022610322263800_r65","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4049\/jimmunol.176.5.3087","article-title":"Mycobacterium bovis bacillus Calmette-Gu\u00e9rin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo","volume":"176","author":"D\u2019Avila","year":"2006","journal-title":"J. Immunol."},{"key":"2025022610322263800_r66","doi-asserted-by":"crossref","first-page":"e1000632","DOI":"10.1371\/journal.ppat.1000632","article-title":"Dengue virus capsid protein usurps lipid droplets for viral particle formation","volume":"5","author":"Samsa","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025022610322263800_r67","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1073\/pnas.94.4.1200","article-title":"Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets","volume":"94","author":"Barba","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025022610322263800_r68","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1074\/jbc.M108798200","article-title":"The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins","volume":"277","author":"Hope","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025022610322263800_r69","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.4049\/jimmunol.0801795","article-title":"Histoplasma capsulatum cell wall beta-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection","volume":"182","author":"Sorgi","year":"2009","journal-title":"J. Immunol."},{"key":"2025022610322263800_r70","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3389\/fimmu.2018.01022","article-title":"Lipid droplet, a key player in host-parasite interactions","volume":"9","author":"Vallochi","year":"2018","journal-title":"Front. Immunol."},{"key":"2025022610322263800_r71","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.4049\/jimmunol.169.11.6498","article-title":"Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism","volume":"169","author":"Pacheco","year":"2002","journal-title":"J. Immunol."},{"key":"2025022610322263800_r72","doi-asserted-by":"crossref","first-page":"22779","DOI":"10.1074\/jbc.M101436200","article-title":"Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils","volume":"276","author":"Bandeira-Melo","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2025022610322263800_r73","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2013.09.007","article-title":"MEF2 is an in vivo immune-metabolic switch","volume":"155","author":"Clark","year":"2013","journal-title":"Cell."},{"key":"2025022610322263800_r74","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.cub.2006.08.052","article-title":"Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila","volume":"16","author":"Dionne","year":"2006","journal-title":"Curr. Biol."},{"key":"2025022610322263800_r75","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s10495-014-0982-3","article-title":"Non-esterified fatty acids activate the ROS-p38-p53\/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro","volume":"19","author":"Song","year":"2014","journal-title":"Apoptosis."},{"key":"2025022610322263800_r76","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.freeradbiomed.2009.10.033","article-title":"Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoa","volume":"48","author":"Koppers","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"2025022610322263800_r77","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1210\/jc.2006-1309","article-title":"Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa","volume":"91","author":"Aitken","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025022610322263800_r78","doi-asserted-by":"crossref","first-page":"e34904","DOI":"10.1371\/journal.pone.0034904","article-title":"Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes","volume":"7","author":"Krawczyk","year":"2012","journal-title":"PLoS One."},{"key":"2025022610322263800_r79","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2020.01.008","article-title":"Renal purge of hemolymphatic lipids prevents the accumulation of ROS-induced inflammatory oxidized lipids and protects Drosophila from tissue damage","volume":"52","author":"Li","year":"2020","journal-title":"Immunity."},{"key":"2025022610322263800_r80","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of Drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell."},{"key":"2025022610322263800_r81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.celrep.2014.08.056","article-title":"Fatty acid uptake and lipid storage induced by HIF-1\u03b1 contribute to cell growth and survival after hypoxia-reoxygenation","volume":"9","author":"Bensaad","year":"2014","journal-title":"Cell Rep."},{"key":"2025022610322263800_r82","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrmicro3420","article-title":"Salmonellae interactions with host processes","volume":"13","author":"LaRock","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"2025022610322263800_r83","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3389\/fimmu.2014.00558","article-title":"Ubiquitination as an efficient molecular strategy employed in salmonella infection","volume":"5","author":"Narayanan","year":"2014","journal-title":"Front. Immunol."},{"key":"2025022610322263800_r84","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1128\/IAI.05478-11","article-title":"The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets","volume":"79","author":"Arena","year":"2011","journal-title":"Infect. Immun."},{"key":"2025022610322263800_r85","doi-asserted-by":"crossref","first-page":"e1006874","DOI":"10.1371\/journal.ppat.1006874","article-title":"Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-\u03b3\/HIF-1\u03b1 signaling and supports host defense","volume":"14","author":"Knight","year":"2018","journal-title":"PLoS Pathog."},{"key":"2025022610322263800_r86","doi-asserted-by":"crossref","first-page":"34998","DOI":"10.1074\/jbc.M111.278853","article-title":"Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)","volume":"286","author":"Gandotra","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025022610322263800_r87","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.200210169","article-title":"Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation","volume":"161","author":"Sztalryd","year":"2003","journal-title":"J. Cell Biol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/207\/9\/2347\/61364946\/ji2100343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/207\/9\/2347\/61364946\/ji2100343.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:42:03Z","timestamp":1740548523000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/207\/9\/2347\/7944334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":87,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2100343","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11]]},"published":{"date-parts":[[2021,11,1]]}}}