{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:27:18Z","timestamp":1792459638280,"version":"4.5.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI123126"],"award-info":[{"award-number":["R01AI123126"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tissue-resident macrophages (TRM\u03a6) are important immune sentinels responsible for maintaining tissue and immune homeostasis within their specific niche. Recently, the origins of TRM\u03a6 have undergone intense scrutiny, in which now most TRM\u03a6 are thought to originate early during embryonic development independent of hematopoietic stem cells (HSCs). We previously characterized two distinct subsets of mouse peritoneal cavity macrophages (M\u03a6) (large and small peritoneal M\u03a6) whose origins and relationship to both fetal and adult long-term (LT) HSCs have not been fully investigated. In this study, we employ highly purified LT-HSC transplantation and in vivo lineage tracing to show a dual ontogeny for large and small peritoneal M\u03a6, in which the initial wave of peritoneal M\u03a6 is seeded from yolk sac\u2013derived precursors, which later require LT-HSCs for regeneration. In contrast, transplanted fetal and adult LT-HSCs are not able to regenerate brain-resident microglia. Thus, we demonstrate that LT-HSCs retain the potential to develop into TRM\u03a6, but their requirement is tissue specific in the peritoneum and brain.<\/jats:p>","DOI":"10.4049\/jimmunol.2100344","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T12:35:52Z","timestamp":1637584552000},"page":"3028-3037","source":"Crossref","is-referenced-by-count":6,"title":["Hematopoietic Stem Cell Requirement for Macrophage Regeneration Is Tissue Specific"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-8306","authenticated-orcid":false,"given":"Devon J","family":"Eddins","sequence":"first","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine , Atlanta, GA"},{"name":"Division of Rheumatology, Department of Pediatrics, Emory University School of Medicine , Atlanta, GA"},{"name":"Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine , Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-5236","authenticated-orcid":false,"given":"Astrid","family":"Kosters","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine , Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Sosa","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-9177","authenticated-orcid":false,"given":"Koshika","family":"Yadava","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonore A","family":"Herzenberg","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7275-5889","authenticated-orcid":false,"given":"Hedwich F","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-906X","authenticated-orcid":false,"given":"Eliver Eid Bou","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine , Atlanta, GA"},{"name":"Division of Rheumatology, Department of Pediatrics, Emory University School of Medicine , Atlanta, GA"},{"name":"Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine , Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"2025022610324421200_r1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ni.2705","article-title":"Tissue-resident macrophages","volume":"14","author":"Davies","year":"2013","journal-title":"Nat. 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