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Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of &amp;gt;1800 anti-mCRP mAb clones identified 3C as a clone recognizing the monomeric, but not polymeric, form of CRP. The anti-mCRP mAb suppressed leukocyte infiltration in thioglycollate-induced peritonitis, attenuated rheumatoid arthritis symptoms in collagen Ab-induced arthritis model mice, and attenuated lupus nephritis symptoms in MRL\/Mp-lpr\/lpr lupus-prone model mice. These data suggest that the anti-mCRP mAb 3C has therapeutic potential against rheumatoid arthritis and lupus nephritis.<\/jats:p>","DOI":"10.4049\/jimmunol.2100349","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T18:20:11Z","timestamp":1630520411000},"page":"1755-1762","source":"Crossref","is-referenced-by-count":21,"title":["Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice"],"prefix":"10.1093","volume":"207","author":[{"given":"Chitose","family":"Fujita","sequence":"first","affiliation":[{"name":"Division of Oncology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital , Osaka ,","place":["Japan"]},{"name":"The Japan-Multinational Trial Organization , Aichi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Sakurai","sequence":"additional","affiliation":[{"name":"The Japan-Multinational Trial Organization , Aichi ,","place":["Japan"]},{"name":"Canon Medical Systems Corporation , Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-6908","authenticated-orcid":false,"given":"Yuki","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Canon Medical Systems Corporation , Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Davis, School of Medicine , Sacramento, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Oncology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital , Osaka ,","place":["Japan"]},{"name":"The Japan-Multinational Trial Organization , Aichi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Oncology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital , Osaka ,","place":["Japan"]},{"name":"The Japan-Multinational Trial Organization , Aichi ,","place":["Japan"]},{"name":"Division of Clinical Immunology and Rheumatology, Kansai Electric Power Hospital , Osaka ,","place":["Japan"]},{"name":"Department of Infectious Diseases, The Tazuke Kofukai Medical Research Institute, Kitano Hospital , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"2025022610321447700_r1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. 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