{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:51:56Z","timestamp":1791949916703,"version":"4.3.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":1077,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006352","name":"Virginia and D.K. Ludwig Fund for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012394","name":"Robert J. Kleberg, Jr. and Helen C. 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Therapeutic blockade of CD47\u2013SIRP\u03b1 interactions is a promising immuno-oncology treatment that promotes clearance of cancer cells. However, CD47\u2013SIRP\u03b1 interactions also maintain homeostatic lymphocyte levels. In this study, we report that the mouse splenic marginal zone B cell population is dependent on intact CD47\u2013SIRP\u03b1 interactions and blockade of CD47 leads to the loss of these cells. This depletion is accompanied by elevated levels of monocyte-recruiting chemokines CCL2 and CCL7 and infiltration of CCR2+Ly6Chi monocytes into the mouse spleen. In the absence of CCR2 signaling, there is no infiltration and reduced marginal zone B cell depletion. These data suggest that CD47 blockade leads to clearance of splenic marginal zone B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.2100352","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T17:20:14Z","timestamp":1646241614000},"page":"1371-1377","source":"Crossref","is-referenced-by-count":6,"title":["CD47 Blockade Leads to Chemokine-Dependent Monocyte Infiltration and Loss of B Cells from the Splenic Marginal Zone"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-8099","authenticated-orcid":false,"given":"Ying Ying","family":"Yiu","sequence":"first","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine , Stanford, CA"},{"name":"Immunology Program, Stanford University , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige 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CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-9770","authenticated-orcid":false,"given":"Lara","family":"Myers","sequence":"additional","affiliation":[{"name":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-402X","authenticated-orcid":false,"given":"Sarah","family":"Galloway","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gars","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Colace","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8523-4911","authenticated-orcid":false,"given":"Kim J","family":"Hasenkrug","sequence":"additional","affiliation":[{"name":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving L","family":"Weissman","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine , Stanford, CA"},{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA"},{"name":"Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine , Stanford, CA"},{"name":"Stanford Cancer Institute, Stanford University School of Medicine , Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-6246","authenticated-orcid":false,"given":"Michal Caspi","family":"Tal","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University School of Medicine , Stanford, CA"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"2025021101004721600_r1","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1126\/science.288.5473.2051","article-title":"Role of CD47 as a marker of self on red blood cells","volume":"288","author":"Oldenborg","year":"2000","journal-title":"Science"},{"key":"2025021101004721600_r2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.it.2010.04.001","article-title":"Macrophages as mediators of tumor immunosurveillance","volume":"31","author":"Jaiswal","year":"2010","journal-title":"Trends Immunol."},{"key":"2025021101004721600_r3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-immunol-032713-120142","article-title":"The interaction between signal regulatory protein alpha (SIRP\u03b1) and CD47: structure, function, and therapeutic 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