{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T09:26:33Z","timestamp":1751707593703,"version":"3.37.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K22 AI116729"],"award-info":[{"award-number":["K22 AI116729"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI132708"],"award-info":[{"award-number":["R01 AI132708"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI130379"],"award-info":[{"award-number":["R01 AI130379"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"HHS | NIH | National Human Genome Research Institute","doi-asserted-by":"publisher","award":["R01 HG010346"],"award-info":[{"award-number":["R01 HG010346"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["1DP2 OD024087"],"award-info":[{"award-number":["1DP2 OD024087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI126851"],"award-info":[{"award-number":["R01 AI126851"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>E-protein transcription factors limit group 2 innate lymphoid cell (ILC2) development while promoting T cell differentiation from common lymphoid progenitors. Inhibitors of DNA binding (ID) proteins block E-protein DNA binding in common lymphoid progenitors to allow ILC2 development. However, whether E-proteins influence ILC2 function upon maturity and activation remains unclear. Mice that overexpress ID1 under control of the thymus-restricted proximal Lck promoter (ID1tg\/WT) have a large pool of primarily thymus-derived ILC2s in the periphery that develop in the absence of E-protein activity. We used these mice to investigate how the absence of E-protein activity affects ILC2 function and the genomic landscape in response to house dust mite (HDM) allergens. ID1tg\/WT mice had increased KLRG1\u2212 ILC2s in the lung compared with wild-type (WT; ID1WT\/WT) mice in response to HDM, but ID1tg\/WT ILC2s had an impaired capacity to produce type 2 cytokines. Analysis of WT ILC2 accessible chromatin suggested that AP-1 and C\/EBP transcription factors but not E-proteins were associated with ILC2 inflammatory gene programs. Instead, E-protein binding sites were enriched at functional genes in ILC2s during development that were later dynamically regulated in allergic lung inflammation, including genes that control ILC2 response to cytokines and interactions with T cells. Finally, ILC2s from ID1tg\/WT compared with WT mice had fewer regions of open chromatin near functional genes that were enriched for AP-1 factor binding sites following HDM treatment. These data show that E-proteins shape the chromatin landscape during ILC2 development to dictate the functional capacity of mature ILC2s during allergic inflammation in the lung.<\/jats:p>","DOI":"10.4049\/jimmunol.2100414","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T16:15:12Z","timestamp":1645200912000},"page":"1007-1020","source":"Crossref","is-referenced-by-count":5,"title":["E-Protein Inhibition in ILC2 Development Shapes the Function of Mature ILC2s during Allergic Airway Inflammation"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-7658","authenticated-orcid":false,"given":"Gilad","family":"Barshad","sequence":"first","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University College of Veterinary Medicine , Ithaca, NY"},{"name":"Department of Biomedical Sciences, Cornell University College of Veterinary Medicine , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-7570","authenticated-orcid":false,"given":"Lauren M","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-An","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyebola O","family":"Oyesola","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluomachi G","family":"Onyekwere","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University College of Veterinary Medicine , Ithaca, NY"},{"name":"Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J","family":"Lewis","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University College of Veterinary Medicine , Ithaca, NY"},{"name":"Department of Biomedical Sciences, Cornell University College of Veterinary Medicine , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J","family":"Rice","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University College of Veterinary Medicine , Ithaca, NY"},{"name":"Department of Biomedical Sciences, Cornell University College of Veterinary Medicine , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-0787","authenticated-orcid":false,"given":"Macy K","family":"Matheson","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-2662","authenticated-orcid":false,"given":"Xiao-Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation , Oklahoma City, OK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-3353","authenticated-orcid":false,"given":"Jakob","family":"von Moltke","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-7125","authenticated-orcid":false,"given":"Charles G","family":"Danko","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University College of Veterinary Medicine , Ithaca, NY"},{"name":"Department of Biomedical Sciences, Cornell University College of Veterinary Medicine , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-296X","authenticated-orcid":false,"given":"Elia D","family":"Tait Wojno","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"2025021008555695400_r1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"2025021008555695400_r2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.coi.2013.07.013","article-title":"Innate lymphoid cells and allergic inflammation","volume":"25","author":"Kim","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"2025021008555695400_r3","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1084\/jem.20160525","article-title":"Emerging concepts and future challenges in innate lymphoid cell biology","volume":"213","author":"Tait Wojno","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025021008555695400_r4","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma. [Published erratum appears in 2021 Cell 184: 2521\u20132522.]","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"2025021008555695400_r5","doi-asserted-by":"crossref","first-page":"eaax0416","DOI":"10.1126\/sciimmunol.aax0416","article-title":"Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33","volume":"4","author":"Mahlak\u00f5iv","year":"2019","journal-title":"Sci. Immunol."},{"key":"2025021008555695400_r6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.immuni.2019.02.002","article-title":"Adventitial stromal cells define group 2 innate lymphoid cell tissue niches","volume":"50","author":"Dahlgren","year":"2019","journal-title":"Immunity"},{"key":"2025021008555695400_r7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2015.07.007","article-title":"Barrier epithelial cells and the control of type 2 immunity","volume":"43","author":"Hammad","year":"2015","journal-title":"Immunity"},{"key":"2025021008555695400_r8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ni.3078","article-title":"IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential \u2018inflammatory\u2019 type 2 innate lymphoid cells","volume":"16","author":"Huang","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025021008555695400_r9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.immuni.2020.02.009","article-title":"Interleukin-33 induces the enzyme tryptophan hydroxylase 1 to promote inflammatory group 2 innate lymphoid cell-mediated immunity","volume":"52","author":"Flamar","year":"2020","journal-title":"Immunity"},{"key":"2025021008555695400_r10","doi-asserted-by":"crossref","first-page":"eaay3994","DOI":"10.1126\/sciimmunol.aay3994","article-title":"BATF acts as an essential regulator of IL-25-responsive migratory ILC2 cell fate and function","volume":"5","author":"Miller","year":"2020","journal-title":"Sci. Immunol."},{"key":"2025021008555695400_r11","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1084\/jem.20130351","article-title":"A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis","volume":"210","author":"Salimi","year":"2013","journal-title":"J. Exp. Med."},{"key":"2025021008555695400_r12","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2016.04.029","article-title":"Developmental acquisition of regulomes underlies innate lymphoid cell functionality","volume":"165","author":"Shih","year":"2016","journal-title":"Cell"},{"key":"2025021008555695400_r13","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1128\/MCB.17.8.4782","article-title":"E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas","volume":"17","author":"Bain","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"2025021008555695400_r14","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1128\/MCB.20.18.6677-6685.2000","article-title":"Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB","volume":"20","author":"Barndt","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2025021008555695400_r15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12026-010-8182-x","article-title":"Stage-specific functions of E-proteins at the \u03b2-selection and T-cell receptor checkpoints during thymocyte development","volume":"49","author":"Jones","year":"2011","journal-title":"Immunol. Res."},{"key":"2025021008555695400_r16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.celrep.2016.09.025","article-title":"Deciphering the innate lymphoid cell transcriptional program","volume":"17","author":"Seillet","year":"2016","journal-title":"Cell Rep."},{"key":"2025021008555695400_r17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4049\/immunohorizons.1900045","article-title":"Development of type 2 innate lymphoid cells is selectively inhibited by sustained E protein activity","volume":"3","author":"Berrett","year":"2019","journal-title":"Immunohorizons"},{"key":"2025021008555695400_r18","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/ni923","article-title":"E-proteins directly regulate expression of activation-induced deaminase in mature B cells","volume":"4","author":"Sayegh","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025021008555695400_r19","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.1800494116","article-title":"E-protein regulatory network links TCR signaling to effector Treg cell differentiation","volume":"116","author":"Han","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021008555695400_r20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/B978-0-12-405943-6.00005-1","article-title":"Id proteins: small molecules, mighty regulators","volume":"110","author":"Ling","year":"2014","journal-title":"Curr. Top. Dev. Biol."},{"key":"2025021008555695400_r21","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.4049\/jimmunol.1602009","article-title":"Downregulation of E protein activity augments an ILC2 differentiation program in the thymus","volume":"198","author":"Wang","year":"2017","journal-title":"J. Immunol."},{"key":"2025021008555695400_r22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.immuni.2017.04.022","article-title":"The E-Id protein axis specifies adaptive lymphoid cell identity and suppresses thymic innate lymphoid cell development","volume":"46","author":"Miyazaki","year":"2017","journal-title":"Immunity"},{"key":"2025021008555695400_r23","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1084\/jem.20182100","article-title":"Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors","volume":"216","author":"Qian","year":"2019","journal-title":"J. Exp. Med."},{"key":"2025021008555695400_r24","first-page":"2758","article-title":"Functional dissection of the lck proximal promoter","volume":"12","author":"Allen","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"2025021008555695400_r25","doi-asserted-by":"crossref","first-page":"8240","DOI":"10.1128\/MCB.19.12.8240","article-title":"Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice","volume":"19","author":"Kim","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"2025021008555695400_r26","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41590-018-0201-4","article-title":"Tissue signals imprint ILC2 identity with anticipatory function","volume":"19","author":"Ricardo-Gonzalez","year":"2018","journal-title":"Nat. Immunol."},{"key":"2025021008555695400_r27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature24029","article-title":"The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. [Published erratum appears in 2017 Nature 551: 658.]","volume":"549","author":"Wallrapp","year":"2017","journal-title":"Nature"},{"key":"2025021008555695400_r28","doi-asserted-by":"crossref","first-page":"21.29.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: a method for assaying chromatin accessibility genome-wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"2025021008555695400_r29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"2025021008555695400_r30","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2025021008555695400_r31","doi-asserted-by":"crossref","first-page":"R137.1","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"2025021008555695400_r32","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11082","article-title":"Topological domains in mammalian genomes identified by analysis of chromatin interactions","volume":"485","author":"Dixon","year":"2012","journal-title":"Nature"},{"key":"2025021008555695400_r33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41421-018-0045-y","article-title":"Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters","volume":"4","author":"Sun","year":"2018","journal-title":"Cell Discov."},{"issue":"D1","key":"2025021008555695400_r34","first-page":"D87","article-title":"JASPAR 2020: update of the open-access database of transcription factor binding profiles","volume":"48","author":"Fornes","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2025021008555695400_r35","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1101\/gr.772403","article-title":"PANTHER: a library of protein families and subfamilies indexed by function","volume":"13","author":"Thomas","year":"2003","journal-title":"Genome Res."},{"key":"2025021008555695400_r36","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.3812","article-title":"MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping","volume":"18","author":"Placek","year":"2017","journal-title":"Nat. Immunol."},{"key":"2025021008555695400_r37","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2016.07.043","article-title":"The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome","volume":"166","author":"Gury-BenAri","year":"2016","journal-title":"Cell"},{"key":"2025021008555695400_r38","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1002\/eji.201646440","article-title":"T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages","volume":"46","author":"Chiang","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"2025021008555695400_r39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaci.2014.10.012","article-title":"Respiratory allergy caused by house dust mites: what do we really know?","volume":"136","author":"Calder\u00f3n","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021008555695400_r40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaci.2015.05.037","article-title":"Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia","volume":"137","author":"Smith","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021008555695400_r41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaci.2017.03.032","article-title":"Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin","volume":"141","author":"Liu","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021008555695400_r42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1074-7613(02)00264-9","article-title":"Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel\/NF-kappaB activities","volume":"16","author":"Kim","year":"2002","journal-title":"Immunity"},{"key":"2025021008555695400_r43","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41385-020-00339-6","article-title":"PPAR\u03b3 enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2","volume":"14","author":"Xiao","year":"2021","journal-title":"Mucosal Immunol."},{"key":"2025021008555695400_r44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025021008555695400_r45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1124\/jpet.118.247734","article-title":"The extracellular cAMP-adenosine pathway in airway smooth muscle","volume":"366","author":"Pacini","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025021008555695400_r46","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The cytokines of asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"key":"2025021008555695400_r47","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3476","article-title":"Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths","volume":"13","author":"Gause","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025021008555695400_r48","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1017\/S0031182017000488","article-title":"The role of rare innate immune cells in type 2 immune activation against parasitic helminths","volume":"144","author":"Webb","year":"2017","journal-title":"Parasitology"},{"key":"2025021008555695400_r49","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41590-019-0567-y","article-title":"The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity. [Published erratum appears in 2020 Nat. Immunol. 21: 354.]","volume":"21","author":"Seillet","year":"2020","journal-title":"Nat. Immunol."},{"key":"2025021008555695400_r50","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.4049\/jimmunol.1601371","article-title":"BATF modulates the Th2 locus control region and regulates CD4+ T cell fate during antihelminth immunity","volume":"197","author":"Bao","year":"2016","journal-title":"J. Immunol."},{"key":"2025021008555695400_r51","doi-asserted-by":"crossref","first-page":"7997","DOI":"10.1038\/ncomms8997","article-title":"Batf is important for IL-4 expression in T follicular helper cells","volume":"6","author":"Sahoo","year":"2015","journal-title":"Nat. Commun."},{"key":"2025021008555695400_r52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.immuni.2019.05.014","article-title":"Single-cell RNA sequencing of the T helper cell response to house dust mites defines a distinct gene expression signature in airway Th2 cells","volume":"51","author":"Tibbitt","year":"2019","journal-title":"Immunity"},{"key":"2025021008555695400_r53","doi-asserted-by":"crossref","first-page":"14866","DOI":"10.1074\/jbc.RA120.013806","article-title":"E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells","volume":"295","author":"Peng","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2025021008555695400_r54","doi-asserted-by":"crossref","first-page":"108716","DOI":"10.1016\/j.celrep.2021.108716","article-title":"The E protein-TCF1 axis controls \u03b3\u03b4 T cell development and effector fate","volume":"34","author":"Fahl","year":"2021","journal-title":"Cell Rep."},{"key":"2025021008555695400_r55","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2014.06.016","article-title":"MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion","volume":"41","author":"Oliphant","year":"2014","journal-title":"Immunity"},{"key":"2025021008555695400_r56","doi-asserted-by":"crossref","first-page":"154527","DOI":"10.1016\/j.cyto.2018.08.021","article-title":"Cytokines and beyond: regulation of innate immune responses during helminth infection","volume":"133","author":"Oyesola","year":"2020","journal-title":"Cytokine"},{"key":"2025021008555695400_r57","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.molcel.2019.06.009","article-title":"Structural features of transcription factors associating with nucleosome binding","volume":"75","author":"Fernandez Garcia","year":"2019","journal-title":"Mol. Cell"},{"key":"2025021008555695400_r58","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-genet-030220-015007","article-title":"Pioneer transcription factors initiating gene network changes","volume":"54","author":"Zaret","year":"2020","journal-title":"Annu. Rev. Genet."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/5\/1007\/61464792\/ji2100414.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/5\/1007\/61464792\/ji2100414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T08:56:15Z","timestamp":1739177775000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/208\/5\/1007\/7924504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2100414","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2022,3]]},"published":{"date-parts":[[2022,3,1]]}}}