{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:29:27Z","timestamp":1791599367987,"version":"4.3.4"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["R01EY023226"],"award-info":[{"award-number":["R01EY023226"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["R01EY029836"],"award-info":[{"award-number":["R01EY029836"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cysteinyl leukotrienes (CysLTs) have been defined as central mediators of inflammation. Despite our extensive understanding of these bioactive lipid mediators in the pathogenesis of diseases such as asthma, allergic rhinitis, and even neurological disorders, information regarding the eye is markedly lacking. As a result, this study examined the expression profiles of two major CysLT receptors, CysLT1 and CysLT2, in the cornea using experimental mouse models of Pseudomonas aeruginosa\u2013induced keratitis with contrasting outcomes: susceptible C57BL\/6 (B6) and resistant BALB\/c. Postinfection, disparate levels of CysLT receptors were accompanied by distinct expression profiles for select proinflammatory and anti-inflammatory cell surface markers detected on macrophages and polymorphonuclear neutrophils between the two strains. Further, inhibition of either CysLT receptor converted the disease response of both strains, where corneal perforation was prevented in B6 mice, and BALB\/c mice fared significantly worse. In addition, receptor antagonist studies revealed changes in inflammatory cell infiltrate phenotypes and an influence on downstream CysLT receptor signaling pathways. Although the B6 mouse model highlights the established proinflammatory activities related to CysLT receptor activation, results generated from BALB\/c mice indicate a protective mechanism that may be essential to disease resolution. Further, basal expression levels of CysLT1 and CysLT2 were significantly higher in uninfected corneas of both mouse strains as opposed to during infection, suggestive of a novel role in homeostatic maintenance within the eye. In light of these findings, therapeutic targeting of CysLT receptors extends beyond inhibition of proinflammatory activities and may impact inflammation resolution, as well as corneal surface homeostasis.<\/jats:p>","DOI":"10.4049\/jimmunol.2100474","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T19:20:31Z","timestamp":1657740031000},"page":"2331-2342","source":"Crossref","is-referenced-by-count":3,"title":["A Dual Role for Cysteinyl Leukotriene Receptors in the Pathogenesis of Corneal Infection"],"prefix":"10.1093","volume":"208","author":[{"given":"Thomas W","family":"Carion","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashten","family":"Stambersky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Shukkur","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-1170","authenticated-orcid":false,"given":"Elizabeth A","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,15]]},"reference":[{"key":"2025021009060984200_r1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.7326\/0003-4819-121-9-199411010-00010","article-title":"The role of leukotrienes in inflammation","volume":"121","author":"Henderson","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"2025021009060984200_r2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0092-8674(91)90556-E","article-title":"A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP","volume":"65","author":"Clark","year":"1991","journal-title":"Cell"},{"key":"2025021009060984200_r3","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.4049\/jimmunol.173.3.1503","article-title":"Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses","volume":"173","author":"Kanaoka","year":"2004","journal-title":"J. Immunol."},{"key":"2025021009060984200_r4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cell.2017.01.041","article-title":"Structural basis of substrate recognition by the multidrug resistance protein MRP1","volume":"168","author":"Johnson","year":"2017","journal-title":"Cell"},{"key":"2025021009060984200_r5","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1016\/S0021-9258(18)51570-2","article-title":"The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils","volume":"264","author":"Lam","year":"1989","journal-title":"J. Biol. Chem."},{"key":"2025021009060984200_r6","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1067\/mai.2003.1332","article-title":"Human eosinophils are activated by cysteine proteases and release inflammatory mediators","volume":"111","author":"Miike","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021009060984200_r7","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.4049\/jimmunol.137.10.3290","article-title":"Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor","volume":"137","author":"Silberstein","year":"1986","journal-title":"J. Immunol."},{"key":"2025021009060984200_r8","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.147.11.3855","article-title":"IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists","volume":"147","author":"Takafuji","year":"1991","journal-title":"J. Immunol."},{"key":"2025021009060984200_r9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000312669","article-title":"Cysteinyl leukotrienes and their receptors: molecular and functional characteristics","volume":"85","author":"Singh","year":"2010","journal-title":"Pharmacology"},{"key":"2025021009060984200_r10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/21658","article-title":"Characterization of the human cysteinyl leukotriene CysLT1 receptor","volume":"399","author":"Lynch","year":"1999","journal-title":"Nature"},{"key":"2025021009060984200_r11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1046\/j.1365-2222.2003.01786.x","article-title":"Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis","volume":"33","author":"Figueroa","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"2025021009060984200_r12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jaci.2005.03.014","article-title":"Expression of functional cysteinyl leukotriene receptors by human basophils","volume":"116","author":"Gauvreau","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021009060984200_r13","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jaci.2014.09.006","article-title":"Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell\/neutrophil crosstalk","volume":"135","author":"Xue","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021009060984200_r14","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaci.2016.12.958","article-title":"Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines","volume":"140","author":"Salimi","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021009060984200_r15","doi-asserted-by":"crossref","first-page":"30531","DOI":"10.1074\/jbc.M003490200","article-title":"Characterization of the human cysteinyl leukotriene 2 receptor","volume":"275","author":"Heise","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025021009060984200_r16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1046\/j.1365-2222.2002.01425.x","article-title":"Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa","volume":"32","author":"Shirasaki","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"2025021009060984200_r17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/intimm\/dxz044","article-title":"The leukotriene receptors as therapeutic targets of inflammatory diseases","volume":"31","author":"Sasaki","year":"2019","journal-title":"Int. Immunol."},{"key":"2025021009060984200_r18","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1074\/jbc.C113.453704","article-title":"Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand","volume":"288","author":"Kanaoka","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2025021009060984200_r19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nature02488","article-title":"Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors","volume":"429","author":"He","year":"2004","journal-title":"Nature"},{"key":"2025021009060984200_r20","doi-asserted-by":"crossref","first-page":"19790","DOI":"10.1074\/jbc.M400360200","article-title":"Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine","volume":"279","author":"Inbe","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2025021009060984200_r21","doi-asserted-by":"crossref","first-page":"eaat9453","DOI":"10.1126\/sciimmunol.aat9453","article-title":"The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation","volume":"3","author":"Bankova","year":"2018","journal-title":"Sci. Immunol."},{"key":"2025021009060984200_r22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1046\/j.1365-2222.2002.01384.x","article-title":"Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism","volume":"32","author":"Fregonese","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"2025021009060984200_r23","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1164\/ajrccm.155.4.9105062","article-title":"The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma","volume":"155","author":"Diamant","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021009060984200_r24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0140-6736(93)91073-U","article-title":"Leukotriene E4 and granulocytic infiltration into asthmatic airways","volume":"341","author":"Laitinen","year":"1993","journal-title":"Lancet"},{"key":"2025021009060984200_r25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S1081-1206(10)61269-0","article-title":"Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin","volume":"93","author":"Saito","year":"2004","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"2025021009060984200_r26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000065175","article-title":"A functional study on CysLT(1) receptors in human eosinophils","volume":"129","author":"Ohshima","year":"2002","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2025021009060984200_r27","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1067\/mai.2002.124269","article-title":"Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils","volume":"109","author":"Bandeira-Melo","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021009060984200_r28","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1080\/21691401.2018.1489264","article-title":"Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption","volume":"46","author":"Zheng","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"2025021009060984200_r29","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1242\/jcs.02579","article-title":"The NF-kappaB pathway","volume":"118","author":"Moynagh","year":"2005","journal-title":"J. Cell Sci."},{"key":"2025021009060984200_r30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(86)90346-6","article-title":"Multiple nuclear factors interact with the immunoglobulin enhancer sequences","volume":"46","author":"Sen","year":"1986","journal-title":"Cell"},{"key":"2025021009060984200_r31","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1101\/gad.3.11.1689","article-title":"A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB","volume":"3","author":"Baeuerle","year":"1989","journal-title":"Genes Dev."},{"key":"2025021009060984200_r32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jhep.2010.03.025","article-title":"The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes","volume":"53","author":"Elsharkawy","year":"2010","journal-title":"J. Hepatol."},{"key":"2025021009060984200_r33","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2025021009060984200_r34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"2025021009060984200_r35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroscience.2019.10.048","article-title":"Cysteinyl leukotriene receptor 2 is involved in inflammation and neuronal damage by mediating microglia M1\/M2 polarization through NF-\u03baB pathway","volume":"422","author":"Zhao","year":"2019","journal-title":"Neuroscience"},{"key":"2025021009060984200_r36","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41385-019-0134-8","article-title":"Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism","volume":"12","author":"Liu","year":"2019","journal-title":"Mucosal Immunol."},{"key":"2025021009060984200_r37","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1167\/iovs.15-17315","article-title":"Efficacy of VIP as treatment for bacteria-induced keratitis against multiple Pseudomonas aeruginosa strains","volume":"56","author":"Carion","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025021009060984200_r38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2003.10.002","article-title":"Corneal response to Pseudomonas aeruginosa infection","volume":"23","author":"Hazlett","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"2025021009060984200_r39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/sj.eye.6702953","article-title":"Characteristics of and risk factors for contact lens-related microbial keratitis in a tertiary referral hospital","volume":"23","author":"Edwards","year":"2009","journal-title":"Eye (Lond.)"},{"key":"2025021009060984200_r40","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.4049\/jimmunol.178.2.1105","article-title":"Vasoactive intestinal peptide balances pro- and anti-inflammatory cytokines in the Pseudomonas aeruginosa-infected cornea and protects against corneal perforation","volume":"178","author":"Szliter","year":"2007","journal-title":"J. Immunol."},{"key":"2025021009060984200_r41","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1096\/fj.201701502R","article-title":"Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis","volume":"32","author":"Carion","year":"2018","journal-title":"FASEB J."},{"key":"2025021009060984200_r42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.prostaglandins.2018.12.001","article-title":"VIP modulates the ALX\/FPR2 receptor axis toward inflammation resolution in a mouse model of bacterial keratitis","volume":"140","author":"Carion","year":"2019","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"2025021009060984200_r43","doi-asserted-by":"crossref","first-page":"12467","DOI":"10.1073\/pnas.93.22.12467","article-title":"Genetic mapping of a murine locus controlling development of T helper 1\/T helper 2 type responses","volume":"93","author":"Gorham","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021009060984200_r44","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.4049\/jimmunol.164.12.6576","article-title":"Prolonged elevation of IL-1 in Pseudomonas aeruginosa ocular infection regulates macrophage-inflammatory protein-2 production, polymorphonuclear neutrophil persistence, and corneal perforation","volume":"164","author":"Rudner","year":"2000","journal-title":"J. Immunol."},{"key":"2025021009060984200_r45","doi-asserted-by":"crossref","DOI":"10.17226\/25801","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals","year":"2011","edition":"8th"},{"key":"2025021009060984200_r46","first-page":"1978","article-title":"Evidence for N-acetylmannosamine as an ocular receptor for P. aeruginosa adherence to scarified cornea","volume":"28","author":"Hazlett","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025021009060984200_r47","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1101\/gr.4.5.S185","article-title":"Optimization and troubleshooting in PCR","volume":"4","author":"Roux","year":"1995","journal-title":"PCR Methods Appl."},{"key":"2025021009060984200_r48","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1100\/tsw.2011.122","article-title":"The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis","volume":"11","author":"Coskun","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"2025021009060984200_r49","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1038\/srep03274","article-title":"Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT2 and CysLT1 receptors","volume":"3","author":"Duah","year":"2013","journal-title":"Sci. Rep."},{"key":"2025021009060984200_r50","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neuroscience.2006.02.051","article-title":"Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats","volume":"140","author":"Fang","year":"2006","journal-title":"Neuroscience"},{"key":"2025021009060984200_r51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2006.10.065","article-title":"Spatio-temporal expression of cysteinyl leukotriene receptor-2 mRNA in rat brain after focal cerebral ischemia","volume":"412","author":"Fang","year":"2007","journal-title":"Neurosci. Lett."},{"key":"2025021009060984200_r52","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1745-7254.2005.00092.x","article-title":"Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors","volume":"26","author":"Hu","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"2025021009060984200_r53","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1038\/sj.onc.1209666","article-title":"Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells","volume":"25","author":"Paruchuri","year":"2006","journal-title":"Oncogene"},{"key":"2025021009060984200_r54","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00228-017-2242-2","article-title":"The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field","volume":"73","author":"Hoxha","year":"2017","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"2025021009060984200_r55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/ajrccm.165.1.2105051","article-title":"A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model","volume":"165","author":"Henderson","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021009060984200_r56","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/icb.2014.104","article-title":"Leukotrienes induce the migration of Th17 cells","volume":"93","author":"Lee","year":"2015","journal-title":"Immunol. Cell Biol."},{"key":"2025021009060984200_r57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.intimp.2018.04.042","article-title":"Montelukast inhibits inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes","volume":"61","author":"Dong","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"2025021009060984200_r58","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1124\/jpet.111.186031","article-title":"A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia\/reperfusion injury and vascular permeability in mice","volume":"339","author":"Ni","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025021009060984200_r59","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.yjmcc.2010.11.013","article-title":"Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury","volume":"50","author":"Becher","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2025021009060984200_r60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jss.2008.02.052","article-title":"Effect of montelukast and MK-886 on hepatic ischemia-reperfusion injury in rats","volume":"153","author":"Daglar","year":"2009","journal-title":"J. Surg. Res."},{"key":"2025021009060984200_r61","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/00015458.2013.11680954","article-title":"Protective effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against intestinal ischemia-reperfusion injury in the rat","volume":"113","author":"Duran","year":"2013","journal-title":"Acta Chir. Belg."},{"key":"2025021009060984200_r62","doi-asserted-by":"crossref","first-page":"e41786","DOI":"10.1371\/journal.pone.0041786","article-title":"Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease","volume":"7","author":"Nobili","year":"2012","journal-title":"PLoS One"},{"key":"2025021009060984200_r63","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.0400235101","article-title":"Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis","volume":"101","author":"Beller","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021009060984200_r64","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0039-6257(87)90025-7","article-title":"Patterns of pathologic response in the cornea","volume":"31","author":"Waring","year":"1987","journal-title":"Surv. Ophthalmol."},{"key":"2025021009060984200_r65","first-page":"649","article-title":"Pseudomonas eye infections in cyclophosphamide-treated mice","volume":"16","author":"Hazlett","year":"1977","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025021009060984200_r66","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000414337","article-title":"Therapy of Pseudomonas aeruginosa eye infections","volume":"39","author":"Thiel","year":"1987","journal-title":"Antibiot Chemother (1971)"},{"key":"2025021009060984200_r67","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol."},{"key":"2025021009060984200_r68","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1189\/jlb.1007689","article-title":"A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone-marrow-derived macrophages to Toll-like receptor agonists","volume":"83","author":"Joshi","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"2025021009060984200_r69","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"key":"2025021009060984200_r70","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1084\/jem.20020044","article-title":"Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists","volume":"195","author":"Mellor","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025021009060984200_r71","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1182\/blood-2007-07-100453","article-title":"CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells","volume":"110","author":"Jiang","year":"2007","journal-title":"Blood"},{"key":"2025021009060984200_r72","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.4049\/jimmunol.173.9.5786","article-title":"A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock","volume":"173","author":"Gadjeva","year":"2004","journal-title":"J. Immunol."},{"key":"2025021009060984200_r73","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1097-2765(02)00477-X","article-title":"The phosphorylation status of nuclear NF-kappa B determines its association with CBP\/p300 or HDAC-1","volume":"9","author":"Zhong","year":"2002","journal-title":"Mol. Cell"},{"key":"2025021009060984200_r74","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/nm1201-1291","article-title":"Possible new role for NF-kappaB in the resolution of inflammation","volume":"7","author":"Lawrence","year":"2001","journal-title":"Nat. Med."},{"key":"2025021009060984200_r75","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13062-016-0164-z","article-title":"Importins promote high-frequency NF-\u03baB oscillations increasing information channel capacity","volume":"11","author":"Korwek","year":"2016","journal-title":"Biol. Direct"},{"key":"2025021009060984200_r76","doi-asserted-by":"crossref","first-page":"24392","DOI":"10.1074\/jbc.M003784200","article-title":"Mechanism of kappa B DNA binding by Rel\/NF-kappa B dimers","volume":"275","author":"Phelps","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025021009060984200_r77","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/j.1460-2075.1991.tb04950.x","article-title":"The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B","volume":"10","author":"Schmitz","year":"1991","journal-title":"EMBO J."},{"key":"2025021009060984200_r78","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1371\/journal.pbio.1000073","article-title":"Two modes of transcriptional activation at native promoters by NF-kappaB p65","volume":"7","author":"van Essen","year":"2009","journal-title":"PLoS Biol."},{"key":"2025021009060984200_r79","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0002-9440(10)62291-2","article-title":"Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury","volume":"166","author":"Oakley","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2025021009060984200_r80","doi-asserted-by":"crossref","first-page":"F429","DOI":"10.1152\/ajprenal.90435.2008","article-title":"Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases","volume":"297","author":"Panzer","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2025021009060984200_r81","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1164\/rccm.200303-412OC","article-title":"Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia","volume":"168","author":"Mizgerd","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021009060984200_r82","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nbd.2013.12.003","article-title":"Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit","volume":"64","author":"Rolova","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"2025021009060984200_r83","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbamcr.2005.12.010","article-title":"Phosphorylation of NF-kappaB1\/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation","volume":"1763","author":"Babu","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"2025021009060984200_r84","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1128\/MCB.23.14.4739-4752.2003","article-title":"NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity","volume":"23","author":"Beinke","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2025021009060984200_r85","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/16946","article-title":"TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105","volume":"397","author":"Belich","year":"1999","journal-title":"Nature"},{"key":"2025021009060984200_r86","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0952-3278(03)00073-5","article-title":"BLT1 and BLT2: the leukotriene B(4) receptors","volume":"69","author":"Tager","year":"2003","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"2025021009060984200_r87","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.4049\/jimmunol.178.6.3912","article-title":"Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation","volume":"178","author":"Arita","year":"2007","journal-title":"J. Immunol."},{"key":"2025021009060984200_r88","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jaci.2019.09.028","article-title":"Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes","volume":"145","author":"Levy","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021009060984200_r89","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/all.12987","article-title":"A dual CysLT1\/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma","volume":"71","author":"Gauvreau","year":"2016","journal-title":"Allergy"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/10\/2331\/61221187\/ji2100474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/10\/2331\/61221187\/ji2100474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T09:06:43Z","timestamp":1739178403000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/208\/10\/2331\/7927273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":89,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2100474","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5]]},"published":{"date-parts":[[2022,5]]}}}