{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:45Z","timestamp":1787030865639,"version":"build-2736575974"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":1244,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1013759"],"award-info":[{"award-number":["1013759"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["FDN-143262"],"award-info":[{"award-number":["FDN-143262"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infiltration of maternal peripheral leukocytes into the uterine tissues is a critical event occurring before, during, and after term labor (TL). In this article, we investigate the contribution of uterine smooth muscle (myometrium) and pregnant endometrium (decidua) to the inflammatory process during human TL. We hypothesize that labor-related physiological inflammation is orchestrated by uterine-secreted cytokines, which dually activate the uterine vascular endothelium and maternal leukocytes to promote their adhesion and infiltration into the uterus. Using Luminex and ELISA assays, we examine a full range of cytokines (45 proteins) in media conditioned by primary decidual and myometrial cells from TL and term not in labor (TNL) women. The effect of conditioned media on the activation of human uterine microvascular endothelial cells was measured by qPCR and on peripheral leukocytes by flow cytometry. Transendothelial migration of calcein-labeled primary leukocytes toward media was assessed by fluorometry. Stromal decidual cells secrete significantly higher levels of multiple cytokines compared with myometrial cells (p &amp;lt; 0.05) and significantly more cytokines during TL than TNL. These cytokines activate uterine microvascular endothelial cells through the upregulation of cell adhesion molecule VCAM-1 and peripheral leukocytes by upregulation of CD11b. Furthermore, multiple cytokines secreted from the TL decidua and myometrium significantly increase migration of granulocytes, monocytes, and lymphocytes compared with TNL (p &amp;lt; 0.05), which was blocked by a broad-spectrum chemokine inhibitor (FX125L). These data reveal the critical role for decidual- and myometrial-secreted cytokines in the activation of inflammatory pathways leading to labor. We suggest that these pathways represent targets for therapeutic intervention during preterm labor.<\/jats:p>","DOI":"10.4049\/jimmunol.2100493","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T14:45:17Z","timestamp":1631717117000},"page":"2015-2026","source":"Crossref","is-referenced-by-count":24,"title":["Decidual Inflammation Drives Chemokine-Mediated Immune Infiltration Contributing to Term Labor"],"prefix":"10.1093","volume":"207","author":[{"given":"Oksana","family":"Shynlova","sequence":"first","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Physiology, University of Toronto , Ontario ,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, University of Toronto , Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Boros-Rausch","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Physiology, University of Toronto , Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Farine","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Physiology, University of Toronto , Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-7224","authenticated-orcid":false,"given":"Kristina M","family":"Adams Waldorf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Washington , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-099X","authenticated-orcid":false,"given":"Caroline","family":"Dunk","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Lye","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Physiology, University of Toronto , Ontario ,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, University of Toronto , Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"2026041420282242000_r1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1749-6632.2001.tb03804.x","article-title":"Understanding preterm labor","volume":"943","author":"Challis","year":"2001","journal-title":"Ann. 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