{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:03:49Z","timestamp":1777125829175,"version":"3.51.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["100873"],"award-info":[{"award-number":["100873"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["110858"],"award-info":[{"award-number":["110858"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["026914"],"award-info":[{"award-number":["026914"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cells must shift their metabolism to respond to infections and tumors and to undergo memory formation. The ATP-binding cassette transporter ABCB10 localizes to the mitochondrial inner membrane, where it is thought to export a substrate important in heme biosynthesis and metabolism, but its role in T cell development and activation is unknown. In this article, we use a combination of methods to study the effect of ABCB10 loss in primary and malignantly transformed T cells. Although Abcb10 is dispensable for development of both CD4+ and CD8+ T cells, it is required for expression of specific cytokines in CD4+, but not CD8+, T cells activated in vitro. These defects in cytokine expression are magnified on repeated stimulation. In vivo, CD8+ cells lacking ABCB10 expand more in response to viral infection than their control counterparts, while CD4+ cells show reductions in both number and percentage. CD4+ cells lacking ABCB10 show impairment in Ag-specific memory formation and recall responses that become more severe with time. In malignant human CD4+ Jurkat T cells, we find that CRISPR-mediated ABCB10 disruption recapitulates the same cytokine expression defects upon activation as observed in primary mouse T cells. Mechanistically, ABCB10 deletion in Jurkat T cells disrupts the ability to switch to aerobic glycolysis upon activation. Cumulatively, these results show that ABCB10 is selectively required for specific cytokine responses and memory formation in CD4+ T cells, suggesting that targeting this molecule could be used to mitigate aberrant T cell activation.<\/jats:p>","DOI":"10.4049\/jimmunol.2100514","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T19:45:14Z","timestamp":1639165514000},"page":"328-337","source":"Crossref","is-referenced-by-count":3,"title":["ABCB10 Loss Reduces CD4+ T Cell Activation and Memory Formation"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-0942","authenticated-orcid":false,"given":"Wenxiang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Utah , Salt Lake City, UT"},{"name":"Huntsman Cancer Institute, School of Medicine, University of Utah , Salt Lake City, UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-0687","authenticated-orcid":false,"given":"Xuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Utah , Salt Lake City, UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-8570","authenticated-orcid":false,"given":"Marc","family":"Liesa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of California , Los Angeles, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-8385","authenticated-orcid":false,"given":"Dean","family":"Tantin","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Utah , Salt Lake City, UT"},{"name":"Huntsman Cancer Institute, School of Medicine, University of Utah , Salt Lake City, UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Utah , Salt Lake City, UT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"2025021008491263400_r1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.smim.2016.10.009","article-title":"Metabolic pathways in T cell activation and lineage differentiation","volume":"28","author":"Almeida","year":"2016","journal-title":"Semin. 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