{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:27:43Z","timestamp":1790746063144,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI132638"],"award-info":[{"award-number":["AI132638"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM092804"],"award-info":[{"award-number":["GM092804"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An impaired neutrophil response to pathogenic fungi puts patients at risk for fungal infections with a high risk of morbidity and mortality. Acquired neutrophil dysfunction in the setting of iatrogenic immune modulators can include the inhibition of critical kinases such as spleen tyrosine kinase (Syk). In this study, we used an established system of conditionally immortalized mouse neutrophil progenitors to investigate the ability to augment Syk-deficient neutrophil function against Candida albicans with TLR agonist signaling. LPS, a known immunomodulatory molecule derived from Gram-negative bacteria, was capable of rescuing effector functions of Syk-deficient neutrophils, which are known to have poor fungicidal activity against Candida species. LPS priming of Syk-deficient mouse neutrophils demonstrates partial rescue of fungicidal activity, including phagocytosis, degranulation, and neutrophil swarming, but not reactive oxygen species production against C. albicans, in part due to c-Fos activation. Similarly, LPS priming of human neutrophils rescues fungicidal activity in the presence of pharmacologic inhibition of Syk and Bruton\u2019s tyrosine kinase (Btk), both critical kinases in the innate immune response to fungi. In vivo, neutropenic mice were reconstituted with wild-type or Syk-deficient neutrophils and challenged i.p. with C. albicans. In this model, LPS improved wild-type neutrophil homing to the fungal challenge, although Syk-deficient neutrophils did not persist in vivo, speaking to its crucial role on in vivo persistence. Taken together, we identify TLR signaling as an alternate activation pathway capable of partially restoring neutrophil effector function against Candida in a Syk-independent manner.<\/jats:p>","DOI":"10.4049\/jimmunol.2100599","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T19:35:13Z","timestamp":1647027313000},"page":"1664-1674","source":"Crossref","is-referenced-by-count":10,"title":["TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils"],"prefix":"10.1093","volume":"208","author":[{"given":"Adam L","family":"Viens","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-0007","authenticated-orcid":false,"given":"Kyle D","family":"Timmer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Barghout","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Massachusetts General Hospital , Boston, MA"},{"name":"Harvard Stem Cell Institute , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Massachusetts General Hospital , Boston, MA"},{"name":"Harvard Stem Cell Institute , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hopke","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA"},{"name":"Shriners Burns Hospital , Boston, MA"},{"name":"Center for Engineering in Medicine and Surgery, Department of Surgery, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J","family":"Atallah","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-3873","authenticated-orcid":false,"given":"Allison K","family":"Scherer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-0221","authenticated-orcid":false,"given":"David B","family":"Sykes","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Massachusetts General Hospital , Boston, MA"},{"name":"Harvard Stem Cell Institute , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-2082","authenticated-orcid":false,"given":"Daniel","family":"Irimia","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA"},{"name":"Shriners Burns Hospital , Boston, MA"},{"name":"Center for Engineering in Medicine and Surgery, Department of Surgery, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K","family":"Mansour","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"2025021009004442800_r1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases\u2014estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J. Fungi (Basel)"},{"key":"2025021009004442800_r2","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2025021009004442800_r3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"key":"2025021009004442800_r4","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s00134-009-1619-9","article-title":"Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients","volume":"35","author":"Playford","year":"2009","journal-title":"Intensive Care Med."},{"key":"2025021009004442800_r5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10096-007-0270-z","article-title":"Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting","volume":"26","author":"Ostrosky-Zeichner","year":"2007","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"2025021009004442800_r6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6808a1","article-title":"Population-based active surveillance for culture-confirmed candidemia\u2014four sites, United States, 2012\u20132016","volume":"68","author":"Toda","year":"2019","journal-title":"MMWR Surveill. Summ."},{"key":"2025021009004442800_r7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"2025021009004442800_r8","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1086\/599039","article-title":"Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry","volume":"48","author":"Horn","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2025021009004442800_r9","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1086\/320757","article-title":"Risk factors and predictors of outcome in patients with cancer and breakthrough candidemia","volume":"32","author":"Uzun","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"2025021009004442800_r10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000321157","article-title":"Organ-specific innate immune responses in a mouse model of invasive candidiasis","volume":"3","author":"Lionakis","year":"2011","journal-title":"J. Innate Immun."},{"key":"2025021009004442800_r11","doi-asserted-by":"crossref","first-page":"e1005293","DOI":"10.1371\/journal.ppat.1005293","article-title":"CARD9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system","volume":"11","author":"Drummond","year":"2015","journal-title":"PLoS Pathog."},{"key":"2025021009004442800_r12","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI106114","article-title":"Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection","volume":"48","author":"Lehrer","year":"1969","journal-title":"J. Clin. Invest."},{"key":"2025021009004442800_r13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00005792-200005000-00004","article-title":"Genetic, biochemical, and clinical features of chronic granulomatous disease","volume":"79","author":"Segal","year":"2000","journal-title":"Medicine (Baltimore)"},{"key":"2025021009004442800_r14","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood-2014-01-551473","article-title":"Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects","volume":"124","author":"Gazendam","year":"2014","journal-title":"Blood"},{"key":"2025021009004442800_r15","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.169.7.3876","article-title":"The \u03b2-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte\/macrophage and neutrophil lineages","volume":"169","author":"Taylor","year":"2002","journal-title":"J. Immunol."},{"key":"2025021009004442800_r16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-030409-101229","article-title":"Innate antifungal immunity: the key role of phagocytes","volume":"29","author":"Brown","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"2025021009004442800_r17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/ni.2369","article-title":"C-type lectin receptors orchestrate antifungal immunity","volume":"13","author":"Hardison","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025021009004442800_r18","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s10096-014-2309-2","article-title":"The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections","volume":"34","author":"Jaeger","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"2025021009004442800_r19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/mmy\/myu029","article-title":"New insights into innate immune control of systemic candidiasis","volume":"52","author":"Lionakis","year":"2014","journal-title":"Med. Mycol."},{"key":"2025021009004442800_r20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(02)00303-5","article-title":"Syk is required for integrin signaling in neutrophils","volume":"16","author":"M\u00f3csai","year":"2002","journal-title":"Immunity"},{"key":"2025021009004442800_r21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from marrow to microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"key":"2025021009004442800_r22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.02043-19","article-title":"Spleen tyrosine kinase is a critical regulator of neutrophil responses to Candida species","volume":"11","author":"Negoro","year":"2020","journal-title":"MBio"},{"key":"2025021009004442800_r23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/cid\/ciy175","article-title":"Serious infections in patients receiving ibrutinib for treatment of lymphoid cancer","volume":"67","author":"Varughese","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"2025021009004442800_r24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/cid\/cix687","article-title":"Call for action: invasive fungal infections associated with ibrutinib and other small molecule kinase inhibitors targeting immune signaling pathways","volume":"66","author":"Chamilos","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"2025021009004442800_r25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11926-016-0572-1","article-title":"Fungal infections and new biologic therapies","volume":"18","author":"Vallabhaneni","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"key":"2025021009004442800_r26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12281-019-00343-9","article-title":"Fungal infections with ibrutinib and other small-molecule kinase inhibitors","volume":"13","author":"Zarakas","year":"2019","journal-title":"Curr. Fungal Infect. Rep."},{"key":"2025021009004442800_r27","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1172\/JCI18696","article-title":"TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase","volume":"112","author":"Fan","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2025021009004442800_r28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1182\/bloodadvances.2019000785","article-title":"Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling","volume":"4","author":"Bellissimo","year":"2020","journal-title":"Blood Adv."},{"key":"2025021009004442800_r29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.coph.2011.06.007","article-title":"The role of TLRs in neutrophil activation","volume":"11","author":"Prince","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"2025021009004442800_r30","doi-asserted-by":"crossref","first-page":"e1005644","DOI":"10.1371\/journal.ppat.1005644","article-title":"Neutrophil attack triggers extracellular trap-dependent Candida cell wall remodeling and altered immune recognition","volume":"12","author":"Hopke","year":"2016","journal-title":"PLoS Pathog."},{"key":"2025021009004442800_r31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/hep4.1645","article-title":"Loss of coordinated neutrophil responses to the human fungal pathogen, Candida albicans, in patients with cirrhosis","volume":"5","author":"Knooihuizen","year":"2021","journal-title":"Hepatol. Commun."},{"key":"2025021009004442800_r32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/infdis\/jiab009","article-title":"Cytokine augmentation reverses transplant recipient neutrophil dysfunction against the human fungal pathogen, Candida albicans","volume":"224","author":"Barros","year":"2021","journal-title":"J. Infect. Dis."},{"key":"2025021009004442800_r33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"2025021009004442800_r34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nmeth865","article-title":"Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8","volume":"3","author":"Wang","year":"2006","journal-title":"Nat. Methods"},{"key":"2025021009004442800_r35","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1182\/blood.V98.8.2308","article-title":"Estrogen-dependent E2a\/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins","volume":"98","author":"Sykes","year":"2001","journal-title":"Blood"},{"key":"2025021009004442800_r36","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/s41467-020-15834-4","article-title":"Neutrophil swarming delays the growth of clusters of pathogenic fungi. [Published erratum appears in 2020 Nat. Commun. 11: 2492.]","volume":"11","author":"Hopke","year":"2020","journal-title":"Nat. Commun."},{"key":"2025021009004442800_r37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4049\/jimmunol.2000807","article-title":"In vivo functions of mouse neutrophils derived from HoxB8-transduced conditionally immortalized myeloid progenitors","volume":"206","author":"Orosz","year":"2021","journal-title":"J. Immunol."},{"key":"2025021009004442800_r38","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1128\/iai.61.5.2216-2219.1993","article-title":"Lipopolysaccharide restores anti-Candida albicans growth inhibition activity of polymorphonuclear neutrophils from retrovirus-immunosuppressed mice","volume":"61","author":"Yamamoto","year":"1993","journal-title":"Infect. Immun."},{"key":"2025021009004442800_r39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/jof7020119","article-title":"Immune sensing of Candida albicans","volume":"7","author":"Bojang","year":"2021","journal-title":"J. Fungi (Basel)"},{"key":"2025021009004442800_r40","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1476-5381.2012.02097.x","article-title":"The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL","volume":"167","author":"Miller","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"2025021009004442800_r41","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1590\/S0100-879X2010007500078","article-title":"Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood","volume":"43","author":"Gomes","year":"2010","journal-title":"Braz. J. Med. Biol. Res."},{"key":"2025021009004442800_r42","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.bbamcr.2012.04.012","article-title":"Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells","volume":"1823","author":"Boots","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"2025021009004442800_r43","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4049\/jimmunol.1900919","article-title":"Mycobacterium tuberculosis lipoarabinomannan activates human neutrophils via a TLR2\/1 mechanism distinct from Pam3CSK4","volume":"204","author":"Hook","year":"2020","journal-title":"J. Immunol."},{"key":"2025021009004442800_r44","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41590-019-0324-2","article-title":"Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat. Immunol."},{"key":"2025021009004442800_r45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0008-8749(85)90164-9","article-title":"Effect of in vivo administration of different adjuvants on the in vitro candidacidal activity of mouse peritoneal cells","volume":"90","author":"Hilgers","year":"1985","journal-title":"Cell. Immunol."},{"key":"2025021009004442800_r46","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.tice.2016.04.002","article-title":"Effects of Toll-like receptor ligands on RAW 264.7 macrophage morphology and zymosan phagocytosis","volume":"48","author":"Sigola","year":"2016","journal-title":"Tissue Cell"},{"key":"2025021009004442800_r47","doi-asserted-by":"crossref","first-page":"L655","DOI":"10.1152\/ajplung.00327.2004","article-title":"LPS activation of Toll-like receptor 4 signals CD11b\/CD18 expression in neutrophils","volume":"288","author":"Zhou","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021009004442800_r48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1248\/bpb.b16-00644","article-title":"Inhibition of neutrophil adhesion and antimicrobial activity by diluted hydrosol prepared from Rosa damascena","volume":"40","author":"Maruyama","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"2025021009004442800_r49","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fimmu.2016.00363","article-title":"Neutrophil integrins and matrix ligands and NET release","volume":"7","author":"O\u2019Brien","year":"2016","journal-title":"Front. Immunol."},{"key":"2025021009004442800_r50","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1182\/blood-2017-11-818286","article-title":"Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib","volume":"131","author":"Ghez","year":"2018","journal-title":"Blood"},{"key":"2025021009004442800_r51","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s11655-018-3003-5","article-title":"Systems-based interactome analysis for hematopoiesis effect of Angelicae sinensis Radix: regulated network of cell proliferation towards hemopoiesis","volume":"25","author":"Zheng","year":"2019","journal-title":"Chin. J. Integr. Med."},{"key":"2025021009004442800_r52","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.4049\/jimmunol.1800085","article-title":"The TLR4 agonist monophosphoryl lipid A drives broad resistance to infection via dynamic reprogramming of macrophage metabolism","volume":"200","author":"Fensterheim","year":"2018","journal-title":"J. Immunol."},{"key":"2025021009004442800_r53","doi-asserted-by":"crossref","first-page":"e32378","DOI":"10.1371\/journal.pone.0032378","article-title":"Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL","volume":"7","author":"Choi","year":"2012","journal-title":"PLoS One"},{"key":"2025021009004442800_r54","first-page":"e00645","article-title":"Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa. Infect","volume":"86","author":"Richardson","year":"2018","journal-title":"Immun."},{"key":"2025021009004442800_r55","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/7\/1664\/61190189\/ji2100599.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/7\/1664\/61190189\/ji2100599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T09:01:10Z","timestamp":1739178070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/208\/7\/1664\/7924566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2100599","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4]]},"published":{"date-parts":[[2022,4,1]]}}}