{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:15:02Z","timestamp":1792790102786,"version":"4.5.0"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"PMU FFF","award":["E-20\/32\/169-UNG"],"award-info":[{"award-number":["E-20\/32\/169-UNG"]}]},{"DOI":"10.13039\/501100002428","name":"FWF","doi-asserted-by":"publisher","award":["35417-B"],"award-info":[{"award-number":["35417-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral immune cell infiltration into the brain is a prominent feature in aging and various neurodegenerative diseases such as Alzheimer\u2019s disease (AD). As AD progresses, CD8+ T cells infiltrate into the brain parenchyma, where they tightly associate with neurons and microglia. The functional properties of CD8+ T cells in the brain are largely unknown. To gain further insights into the putative functions of CD8+ T cells in the brain, we explored and compared the transcriptomic profile of CD8+ T cells isolated from the brain and blood of transgenic AD (APPswe\/PSEN1dE9, line 85 [APP-PS1]) and age-matched wild-type (WT) mice. Brain CD8+ T cells of APP-PS1 and WT animals had similar transcriptomic profiles and substantially differed from blood circulating CD8+ T cells. The gene signature of brain CD8+ T cells identified them as tissue-resident memory (Trm) T cells. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis on the significantly upregulated genes revealed overrepresentation of biological processes involved in IFN-\u03b2 signaling and the response to viral infections. Furthermore, brain CD8+ T cells of APP-PS1 and aged WT mice showed similar differentially regulated genes as brain Trm CD8+ T cells in mouse models with acute virus infection, chronic parasite infection, and tumor growth. In conclusion, our profiling of brain CD8+ T cells suggests that in AD, these cells exhibit similar adaptive immune responses as in other inflammatory diseases of the CNS, potentially opening the door for immunotherapy in AD.<\/jats:p>","DOI":"10.4049\/jimmunol.2100737","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T13:47:36Z","timestamp":1666273656000},"page":"1272-1285","source":"Crossref","is-referenced-by-count":77,"title":["Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer\u2019s Disease Transgenic Mice as Tissue-Resident Memory T Cells"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-5206","authenticated-orcid":false,"given":"Barbara","family":"Altendorfer","sequence":"first","affiliation":[{"name":"Institute of Molecular Regenerative Medicine, Paracelsus Medical University , Salzburg,","place":["Austria"]},{"name":"Spinal Cord Injury and Tissue Regeneration 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