{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:54:32Z","timestamp":1791550472625,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL087778"],"award-info":[{"award-number":["HL087778"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011500","name":"Nationwide Children's | Research Institute, Nationwide Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Respiratory syncytial virus (RSV) infection in infancy is associated with increased risk of asthma, except in those with allergic disease at the time of infection. Using house dust mite allergen, we examined the effect of pre-existing atopy on postviral airway disease using Sendai virus in mice, which models RSV infection in humans. Sendai virus drives postviral airway disease in nonatopic mice; however, pre-existing atopy protected against the development of airway disease. This protection depended upon neutrophils, as depletion of neutrophils at the time of infection restored the susceptibility of atopic mice to postviral airway disease. Associated with development of atopy was an increase in polymorphonuclear neutrophil\u2013dendritic cell hybrid cells that develop in Th2 conditions and demonstrated increased viral uptake. Systemic inhibition of IL-4 reversed atopic protection against postviral airway disease, suggesting that increased virus uptake by neutrophils was IL-4 dependent. Finally, human neutrophils from atopic donors were able to reduce RSV infection of human airway epithelial cells in vitro, suggesting these findings could apply to the human. Collectively our data support the idea that pre-existing atopy derives a protective neutrophil response via potential interaction with IL-4, preventing development of postviral airway disease.<\/jats:p>","DOI":"10.4049\/jimmunol.2100766","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T19:42:47Z","timestamp":1633722167000},"page":"2589-2597","source":"Crossref","is-referenced-by-count":11,"title":["Atopic Neutrophils Prevent Postviral Airway Disease"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-7303","authenticated-orcid":false,"given":"Syed-Rehan A","family":"Hussain","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Nationwide Children\u2019s Hospital and The Ohio State University College of Medicine , Columbus, OH"},{"name":"Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Rohlfing","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Nationwide Children\u2019s Hospital and The Ohio State University College of Medicine , Columbus, OH"},{"name":"Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Resiliac","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Nationwide Children\u2019s Hospital and The Ohio State University College of Medicine , Columbus, OH"},{"name":"Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"},{"name":"Biomedical Sciences Graduate Program, The Ohio State University College of Medicine , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Nationwide Children\u2019s Hospital and The Ohio State University College of Medicine , Columbus, OH"},{"name":"Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-317X","authenticated-orcid":false,"given":"Mark E","family":"Peeples","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine , Columbus, OH"},{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Garcin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Medicine, University Medical Center , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-2122","authenticated-orcid":false,"given":"Mitchell H","family":"Grayson","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Nationwide Children\u2019s Hospital and The Ohio State University College of Medicine , Columbus, OH"},{"name":"Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"},{"name":"Biomedical Sciences Graduate Program, The Ohio State University College of Medicine , Columbus, OH"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"2025022610322868500_r1","first-page":"547","article-title":"Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001--2009","volume":"60","author":"Centers for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR Morb. 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