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Many patients with IPF demonstrate distinctive lymphocytic interstitial infiltrations within remodeled lung tissue with uncertain pathogenetic relevance. Histopathological examination of explant lung tissue of patients with IPF revealed accentuated lymphoplasmacellular accumulations in close vicinity to, or even infiltrating, remodeled lung tissue. Similarly, we found significant accumulations of B cells interfused with T cells within remodeled lung tissue in two murine models of adenoviral TGF-\u03b21 or bleomycin (BLM)-induced lung fibrosis. Such B cell accumulations coincided with significantly increased lung collagen deposition, lung histopathology, and worsened lung function in wild-type (WT) mice. Surprisingly, B cell\u2013deficient \u00b5MT knockout mice exhibited similar lung tissue remodeling and worsened lung function upon either AdTGF-\u03b21 or BLM as for WT mice. Comparative transcriptomic profiling of sorted B cells collected from lungs of AdTGF-\u03b21\u2013 and BLM-exposed WT mice identified a large set of commonly regulated genes, but with significant enrichment observed for Gene Ontology terms apparently not related to lung fibrogenesis. Collectively, although we observed B cell accumulations in lungs of IPF patients as well as two experimental models of lung fibrosis, comparative profiling of characteristic features of lung fibrosis between WT and B cell\u2013deficient mice did not support a major involvement of B cells in lung fibrogenesis in mice.<\/jats:p>","DOI":"10.4049\/jimmunol.2100767","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T17:30:31Z","timestamp":1644600631000},"page":"1259-1271","source":"Crossref","is-referenced-by-count":17,"title":["B Cells Are Not Involved in the Regulation of Adenoviral TGF-\u03b21\u2013 or Bleomycin-Induced Lung Fibrosis in Mice"],"prefix":"10.1093","volume":"208","author":[{"given":"Marie T","family":"Moog","sequence":"first","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-4753","authenticated-orcid":false,"given":"Christopher","family":"Hinze","sequence":"additional","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-4641","authenticated-orcid":false,"given":"Tina","family":"Bormann","sequence":"additional","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Aschenbrenner","sequence":"additional","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Institute of Functional and Applied Anatomy, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"DeLuca","sequence":"additional","affiliation":[{"name":"German Center for Lung Research, partner site Biomedical Research in Endstage and Obstructive Lung Disease Hanover , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-2281","authenticated-orcid":false,"given":"Danny","family":"Jonigk","sequence":"additional","affiliation":[{"name":"German Center for Lung Research, partner site Biomedical Research in Endstage and Obstructive Lung Disease Hanover , Hannover,","place":["Germany"]},{"name":"Institute of Pathology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Neubert","sequence":"additional","affiliation":[{"name":"German Center for Lung Research, partner site Biomedical Research in Endstage and Obstructive Lung Disease Hanover , Hannover,","place":["Germany"]},{"name":"Institute of Pathology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-7356","authenticated-orcid":false,"given":"Tobias","family":"Welte","sequence":"additional","affiliation":[{"name":"German Center for Lung Research, partner site Biomedical Research in Endstage and Obstructive Lung Disease Hanover , Hannover,","place":["Germany"]},{"name":"Clinic for Pneumology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Gauldie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology, and Molecular Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-1467","authenticated-orcid":false,"given":"Martin","family":"Kolb","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology, and Molecular Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich A","family":"Maus","sequence":"additional","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover,","place":["Germany"]},{"name":"German Center for Lung Research, partner site Biomedical Research in Endstage and Obstructive Lung Disease Hanover , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"2025021008562847700_r1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1183\/09031936.00185114","article-title":"Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review","volume":"46","author":"Hutchinson","year":"2015","journal-title":"Eur. 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