{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:24:55Z","timestamp":1769732695079,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7-PEOPLE-2012-ITN 317040-QuanTI"],"award-info":[{"award-number":["FP7-PEOPLE-2012-ITN 317040-QuanTI"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"EC | European Research Council","doi-asserted-by":"publisher","award":["260934"],"award-info":[{"award-number":["260934"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Scientific Council"},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["ALWOP.265"],"award-info":[{"award-number":["ALWOP.265"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The potential of memory T cells to provide protection against reinfection is beyond question. Yet, it remains debated whether long-term T cell memory is due to long-lived memory cells. There is ample evidence that blood-derived memory phenotype CD8+ T cells maintain themselves through cell division, rather than through longevity of individual cells. It has recently been proposed, however, that there may be heterogeneity in the lifespans of memory T cells, depending on factors such as exposure to cognate Ag. CMV infection induces not only conventional, contracting T cell responses, but also inflationary CD8+ T cell responses, which are maintained at unusually high numbers, and are even thought to continue to expand over time. It has been proposed that such inflating T cell responses result from the accumulation of relatively long-lived CMV-specific memory CD8+ T cells. Using in vivo deuterium labeling and mathematical modeling, we found that the average production rates and expected lifespans of mouse CMV-specific CD8+ T cells are very similar to those of bulk memory-phenotype CD8+ T cells. Even CMV-specific inflationary CD8+ T cell responses that differ 3-fold in size were found to turn over at similar rates.<\/jats:p>","DOI":"10.4049\/jimmunol.2100883","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T17:15:19Z","timestamp":1643390119000},"page":"799-806","source":"Crossref","is-referenced-by-count":6,"title":["Turnover of Murine Cytomegalovirus\u2013Expanded CD8+ T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-8839","authenticated-orcid":false,"given":"Mariona","family":"Baliu-Piqu\u00e9","sequence":"first","affiliation":[{"name":"Center for Translational Immunology, University Medical Center Utrecht , Utrecht,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-8459","authenticated-orcid":false,"given":"Julia","family":"Drylewicz","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, University Medical Center Utrecht , Utrecht,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9091-1630","authenticated-orcid":false,"given":"Xiaoyan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Viral Immunology, Helmholtz Centre for Infection Research , Braunschweig,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-649X","authenticated-orcid":false,"given":"Lisa","family":"Borkner","sequence":"additional","affiliation":[{"name":"Department of Viral Immunology, Helmholtz Centre for Infection Research , Braunschweig,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-1053","authenticated-orcid":false,"given":"Arpit C","family":"Swain","sequence":"additional","affiliation":[{"name":"Theoretical Biology, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid A","family":"Otto","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, University Medical Center Utrecht , Utrecht,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-691X","authenticated-orcid":false,"given":"Rob J","family":"de Boer","sequence":"additional","affiliation":[{"name":"Theoretical Biology, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-0814","authenticated-orcid":false,"given":"Kiki","family":"Tesselaar","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, University Medical Center Utrecht , Utrecht,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-778X","authenticated-orcid":false,"given":"Luka","family":"Cicin-Sain","sequence":"additional","affiliation":[{"name":"Department of Viral Immunology, Helmholtz Centre for Infection Research , Braunschweig,","place":["Germany"]},{"name":"German Center for Infection Research, Partner Site , Hannover-Braunschweig,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2931-0390","authenticated-orcid":false,"given":"Jos\u00e9 A M","family":"Borghans","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, University Medical Center Utrecht , Utrecht,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"2025021008544084100_r1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/360264a0","article-title":"Lifespan of human lymphocyte subsets defined by CD45 isoforms","volume":"360","author":"Michie","year":"1992","journal-title":"Nature"},{"key":"2025021008544084100_r2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.smim.2004.02.008","article-title":"Immunological memory in humans","volume":"16","author":"Crotty","year":"2004","journal-title":"Semin. 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