{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:20:44Z","timestamp":1784694044030,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>ICOS is induced in activated T cells and its main role is to boost differentiation and function of effector T cells. ICOS is also constitutively expressed in a subpopulation of Foxp3+ regulatory T cells under steady-state condition. Studies using ICOS germline knockout mice or ICOS-blocking reagents suggested that ICOS has supportive roles in regulatory T (Treg) cell homeostasis, migration, and function. To avoid any compounding effects that may arise from ICOS-deficient non\u2013Treg cells, we generated a conditional knockout system in which ICOS expression is selectively abrogated in Foxp3-expressing cells (ICOS FC mice). Compared to Foxp3-Cre control mice, ICOS FC mice showed a minor numerical deficit of steady-state Treg cells but did not show any signs of spontaneous autoimmunity, indicating that tissue-protective Treg populations do not heavily rely on ICOS costimulation. However, ICOS FC mice showed more severe inflammation in oxazolone-induced contact hypersensitivity, a model of atopic dermatitis. This correlated with elevated numbers of inflammatory T cells expressing IFN-\u03b3 and\/or TNF-\u03b1 in ICOS FC mice compared with the control group. In contrast, elimination of ICOS in all T cell compartments negated the differences, confirming that ICOS has a dual positive role in effector and Treg cells. Single-cell transcriptome analysis suggested that ICOS-deficient Treg cells fail to mature into T-bet+CXCR3+ \u201cTh1-Treg\u201d cells in the draining lymph node. Our results suggest that regimens that preferentially stimulate ICOS pathways in Treg cells might be beneficial for the treatment of Th1-driven inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.2100897","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T15:16:21Z","timestamp":1657811781000},"page":"301-309","source":"Crossref","is-referenced-by-count":8,"title":["ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-3756","authenticated-orcid":false,"given":"Jinsam","family":"Chang","sequence":"first","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Molecular Biology Program, University of Montreal , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-5015","authenticated-orcid":false,"given":"Antoine","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Molecular Biology Program, University of Montreal , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Bouklouch","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-8178","authenticated-orcid":false,"given":"Vincent","family":"Panneton","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Department of Microbiology, Infectiology and Immunology, University of Montreal , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-8722","authenticated-orcid":false,"given":"Joanna","family":"Li","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, McGill University , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoletta","family":"Diamantopoulos","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, McGill University , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Mohammaei","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Division of Experimental Medicine, McGill University , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Istomine","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, McGill University , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-5790","authenticated-orcid":false,"given":"Fernando","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, McGill University , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7703-6779","authenticated-orcid":false,"given":"Ciriaco A","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, McGill University , Montreal, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-3283","authenticated-orcid":false,"given":"Woong-Kyung","family":"Suh","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al , Montreal, QC,","place":["Canada"]},{"name":"Molecular Biology Program, University of Montreal , Montreal, Quebec,","place":["Canada"]},{"name":"Department of Microbiology, Infectiology and Immunology, University of Montreal , Montreal, Quebec,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, McGill University , Montreal, 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