{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:50:53Z","timestamp":1773435053138,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL145152"],"award-info":[{"award-number":["R01HL145152"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35HL135805"],"award-info":[{"award-number":["R35HL135805"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients. By inducing a severe acute respiratory syndrome\u2013like pulmonary disease model through infecting A\/J mice with murine hepatitis virus strain 1 (MHV-1), we show that i.v. administration of pazopanib ameliorates acute lung injuries without affecting MHV-1 replication. Pazopanib reduces cell apoptosis in MHV-1\u2013infected lungs. Furthermore, we also identified that pazopanib has to be given no later than 48 h after the virus infection without compromising the therapeutic effect. Our study provides a potential treatment for coronavirus-induced lung injuries and support for further evaluation of pazopanib in COVID-19 patients.<\/jats:p>","DOI":"10.4049\/jimmunol.2100968","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T04:54:12Z","timestamp":1672721652000},"page":"723-730","source":"Crossref","is-referenced-by-count":5,"title":["Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries"],"prefix":"10.1093","volume":"209","author":[{"given":"Yi","family":"Luan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine , New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine , New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7039-5330","authenticated-orcid":false,"given":"Qijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine , New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-1561","authenticated-orcid":false,"given":"Susan","family":"Compton","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, School of Medicine, Yale University , New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine , New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine , New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"2025021008254716700_r1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101186","article-title":"COVID-19 cardiovascular connection: a review of cardiac manifestations in COVID-19 infection and treatment modalities","author":"Maitz","year":"2022","journal-title":"Curr. 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