{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:24:54Z","timestamp":1777433094801,"version":"3.51.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":985,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sigurd och Elsa Goljes Minne"},{"name":"Instituto Carlos Chagas, Funda\u00e7\u00e3o Oswaldo Cruz"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inoculation of Mycobacterium bovis Bacille Calmette-Gu\u00e9rin (BCG) in the skin mobilizes local dendritic cells (DC) to the draining lymph node (dLN) in a process that remains incompletely understood. In this study, a mouse model of BCG skin infection was used to investigate mechanisms of skin DC migration to dLNs. We found enhanced transcription of cyclooxygenase (COX)-2 and production of COX-derived PGE2 early after BCG infection in skin. Animals treated with antagonists for COX or the PGE2 receptors EP2 and EP4 displayed a marked reduction in the entry of skin DCs and BCG to dLNs, uncovering an important contribution of COX-derived PGE2 in this migration process. In addition, live BCG bacilli were needed to invoke DC migration through this COX-PGE2 pathway. Having previously shown that IL-1R partially regulates BCG-induced relocation of skin DCs to dLNs, we investigated whether PGE2 release was under control of IL-1. Interestingly, IL-1R ligands IL-1\u03b1\/\u03b2 were not required for early transcription of COX-2 or production of PGE2 in BCG-infected skin, suggesting that the DC migration-promoting role of PGE2 is independent of IL-1\u03b1\/\u03b2 in our model. In DC adoptive transfer experiments, EP2\/EP4, but not IL-1R, was needed on the moving DCs for full-fledged migration, supporting different modes of action for PGE2 and IL-1\u03b1\/\u03b2. In summary, our data highlight an important role for PGE2 in guiding DCs to dLNs in an IL-1\u2013independent manner.<\/jats:p>","DOI":"10.4049\/jimmunol.2100981","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T14:50:16Z","timestamp":1651848616000},"page":"2549-2557","source":"Crossref","is-referenced-by-count":6,"title":["Cyclooxygenase-Derived Prostaglandin E2 Drives IL-1\u2013Independent <i>Mycobacterium bovis<\/i> Bacille Calmette-Gu\u00e9rin\u2013Triggered Skin Dendritic Cell Migration to Draining Lymph Node"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-6266","authenticated-orcid":false,"given":"Veronika","family":"Krmesk\u00e1","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-3211","authenticated-orcid":false,"given":"Juliana Bernardi","family":"Aggio","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Instituto Carlos Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Curitiba,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Nyl\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-2647","authenticated-orcid":false,"given":"Pryscilla Fanini","family":"Wowk","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Instituto Carlos Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Curitiba,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-7240","authenticated-orcid":false,"given":"Antonio Gigliotti","family":"Rothfuchs","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2025021009071784700_r1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/B978-0-12-417028-5.00002-8","article-title":"Dendritic cell migration through the lymphatic vasculature to lymph nodes","volume":"120","author":"Platt","year":"2013","journal-title":"Adv. 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Immunol."},{"key":"2025021009071784700_r21","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1128\/IAI.00417-06","article-title":"Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection","volume":"74","author":"Raupach","year":"2006","journal-title":"Infect. 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Immunol."},{"key":"2025021009071784700_r24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2025021009071784700_r25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.clim.2006.01.016","article-title":"Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases","volume":"119","author":"Park","year":"2006","journal-title":"Clin. Immunol."},{"key":"2025021009071784700_r26","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.2000928","article-title":"Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node","volume":"206","author":"Aggio","year":"2021","journal-title":"J. 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Immunol."},{"key":"2025021009071784700_r30","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1182\/blood-2001-11-0017","article-title":"Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells","volume":"100","author":"Scandella","year":"2002","journal-title":"Blood"},{"key":"2025021009071784700_r31","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1182\/blood-2007-05-090613","article-title":"PGE2-induced metalloproteinase-9 is essential for dendritic cell migration","volume":"111","author":"Yen","year":"2008","journal-title":"Blood"},{"key":"2025021009071784700_r32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2015.12.010","article-title":"Inflammation-induced CCR7 oligomers form scaffolds to integrate distinct signaling pathways for Efficient cell migration","volume":"44","author":"Hauser","year":"2016","journal-title":"Immunity"},{"key":"2025021009071784700_r33","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1182\/blood-2001-12-0360","article-title":"Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets","volume":"100","author":"Luft","year":"2002","journal-title":"Blood"},{"key":"2025021009071784700_r34","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00262-019-02470-1","article-title":"Prostaglandin E2 in a TLR3- and 7\/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells","volume":"69","author":"Gierlich","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"key":"2025021009071784700_r35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3892\/ijmm.2020.4801","article-title":"Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells","volume":"47","author":"Diao","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"2025021009071784700_r36","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.4049\/jimmunol.168.9.4361","article-title":"Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin","volume":"168","author":"Ratzinger","year":"2002","journal-title":"J. Immunol."},{"key":"2025021009071784700_r37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature13489","article-title":"Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk","volume":"511","author":"Mayer-Barber","year":"2014","journal-title":"Nature"},{"key":"2025021009071784700_r38","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.4049\/jimmunol.179.2.1178","article-title":"IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection","volume":"179","author":"Fremond","year":"2007","journal-title":"J. Immunol."},{"key":"2025021009071784700_r39","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1189\/jlb.1002483","article-title":"Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes","volume":"73","author":"Harizi","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"2025021009071784700_r40","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1182\/blood-2011-03-342428","article-title":"Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells","volume":"119","author":"Singh","year":"2012","journal-title":"Blood"},{"key":"2025021009071784700_r41","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/infdis\/jis609","article-title":"An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice","volume":"206","author":"Kaul","year":"2012","journal-title":"J. Infect. Dis."},{"key":"2025021009071784700_r42","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nm872","article-title":"Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells","volume":"9","author":"Kabashima","year":"2003","journal-title":"Nat. Med."},{"key":"2025021009071784700_r43","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4049\/jimmunol.176.2.966","article-title":"Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors","volume":"176","author":"Legler","year":"2006","journal-title":"J. Immunol."},{"key":"2025021009071784700_r44","first-page":"31","article-title":"Experimental studies of vaccination, allergy, and immunity in tuberculosis. 2. Effect of varying the dose of BCG","volume":"12","author":"Tuberculosis Program, Public Health Service","year":"1955","journal-title":"Bull. 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Urol."},{"key":"2025021009071784700_r47","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1128\/iai.63.5.2033-2040.1995","article-title":"Influence of mouse strain and vaccine viability on T-cell responses induced by Mycobacterium bovis bacillus Calmette-Gu\u00e9rin","volume":"63","author":"Daugelat","year":"1995","journal-title":"Infect. Immun."},{"key":"2025021009071784700_r48","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.4049\/jimmunol.158.4.1742","article-title":"Differential responses to challenge with live and dead Mycobacterium bovis Bacillus Calmette-Gu\u00e9rin","volume":"158","author":"Chambers","year":"1997","journal-title":"J. Immunol."},{"key":"2025021009071784700_r49","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s10096-020-03843-6","article-title":"Tuberculosis vaccine development: from classic to clinical candidates","volume":"39","author":"Li","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. 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